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N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide

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Identification
Molecular formula
C12H19N3O
CAS number
128018-61-1
IUPAC name
N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide
State
State
At room temperature, N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide exists as a solid, typically forming a crystalline powder.
Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
510.30
Boiling point (Kelvin)
783.50
General information
Molecular weight
219.29g/mol
Molar mass
219.2940g/mol
Density
1.1450g/cm3
Appearence

N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide appears as a colorless to light yellow solid compound. Being amorphous, it may form either a powder or crystalline structure when solid.

Comment on solubility

Solubility of N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide (C12H19N3O)

The solubility of N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide in various solvents is an important aspect to consider in its application, particularly in pharmaceuticals. This compound possesses unique structural features that influence its solubility characteristics.

Factors Influencing Solubility

Several factors can affect the solubility of this compound:

  • Polarity: The presence of the hydrazino and amide functional groups may increase polarity, which could enhance solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds can contribute to solubility. The amide group facilitates interactions with water molecules.
  • Hydrophobic Interactions: Conversely, the isopropyl group can lead to increased hydrophobicity, potentially making the compound less soluble in water but more soluble in organic solvents.

Solubility in Common Solvents

In order to assess its potential uses, solubility behavior in common solvents may be described as:

  • Soluble: Likely in organic solvents like ethanol, methanol, or acetone due to its hydrophobic regions.
  • Moderately Soluble: In polar solvents, the solubility can vary and may require specific conditions to achieve a desirable concentration.
  • Insoluble: In highly nonpolar solvents due to the overall balance of hydrophilic and hydrophobic elements in the structure.

In summary, the solubility of N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide is influenced by its structural properties, and one should consider the solvent properties when evaluating its applicability in different chemical environments.

Interesting facts

Interesting Facts About N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide

N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide is a fascinating compound with a range of intriguing characteristics:

  • Biological Activity: This compound has been studied for its potential as a pharmacological agent, particularly in the field of medicinal chemistry. Its structure suggests it may have interesting interactions with biological targets.
  • Synthesized for Purpose: It is typically synthesized through specific chemical reactions involving hydrazine and isopropyl derivatives, demonstrating the beauty of organic synthesis in creating tailored molecules for research.
  • Hydrazine Moiety: The presence of a hydrazino group contributes to its potential reactivity. Compounds containing hydrazines are often associated with diverse biological and chemical activities, making this compound a subject of interest in studies of drug design.
  • Structure-Activity Relationship (SAR): Researchers are keen on studying how structural variations in this compound can affect its biological activity, leading to insights in developing more effective drugs.
  • Potential Applications: Beyond medicinal applications, compounds similar to N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide might find uses in agrochemicals and other fields that leverage the properties of hydrazine derivatives.

In summary, N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide exemplifies the intricate link between chemical structure and biological function, making it an exciting compound for both scientists and chemistry students alike.

Synonyms
procarbazine
671-16-9
Procarbazin
Ibenzmethyzin
Ibenzmethyzine
Procarbazina
Procarbazin [German]
Procarbazinum
Procarbazinum [INN-Latin]
Procarbazina [INN-Spanish]
N-Isopropyl-4-((2-methylhydrazinyl)methyl)benzamide
Procarbazine [INN:BAN]
Procarbacine
N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine
p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide
2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine
1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine
4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide
Ro 4-6467
4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide
Procarbazine (INN)
N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide
N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide
N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide
Procarbazine free base
CB 400-497
CCRIS 2389
HSDB 3250
N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide
EINECS 211-582-2
N-(1-Methylethyl)-4-[(2-methylhydrazino)methyl]benzamide
BRN 0958270
p-(N'-Methylhydrazinomethyl)-N-isopropylbenzamide
Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-
DTXSID4021189
MIH
CHEBI:71417
RO-4-6467 FREE BASE
Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-
PROCARBAZINE [MI]
PCX
PROCARBAZINE [INN]
35S93Y190K
PROCARBAZINE [HSDB]
PROCARBAZINE [VANDF]
p-Toluamide, N-isopropyl-alpha-(2-methylhydrazino)-
PROCARBAZINE [WHO-DD]
RO-4-6467
DTXCID301189
671-16-9 (free base)
4-[(2-methylhydrazin-1-yl)methyl]-N-(propan-2-yl)benzamide
N-Isopropyl-.alpha.-(2-methylhydrazino)-p-toluamide
CB 400-497; Ibenzmethyzine; MIH
p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-
Ro-4646711
N-isopropyl-a-(2-methylhydrazino)-p-toluamide
Procarbazinum (INN-Latin)
Procarbazina (INN-Spanish)
PROCARBAZIN (GERMAN)
NCGC00016438-01
CAS-366-70-1
IBZ
N-Isopropyl-4-((2-methylhydrazino)methyl)benzamide
Ro-4-6467/1
Benzethyzin
Indicarb
4-((2-methylhydrazin-1-yl)methyl)-N-(propan-2-yl)benzamide
SR-01000763375
UNII-35S93Y190K
SRI-10847
MBH (Salt/Mix)
Matulane (Salt/Mix)
Nathulane (Salt/Mix)
Natunalar (Salt/Mix)
Prestwick0_001112
Prestwick1_001112
Prestwick2_001112
Prestwick3_001112
SCHEMBL4656
CHEMBL1321
NCIOpen2_004074
BSPBio_001244
BIDD:GT0183
SPBio_003112
BPBio1_001369
GTPL7278
L01XB01
N-(1-METHYLETHYL)-4-
HMS2090J09
Pharmakon1600-01502326
BCP12198
Tox21_301738
Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-(9CI)
HY-13733A
NSC759626
STL483417
AKOS015891211
AC-4547
CCG-213031
DB01168
NSC-759626
NCGC00016438-02
NCGC00016438-05
NCGC00255280-01
CAS-671-16-9
NCI60_041703
SRI-10847-09
SRI-10847-10
SRI-10847_11
SRI-10847_13
DB-082065
CS-0012387
NS00003685
C07402
D08423
EN300-708801
Q418656
SR-01000763375-3
BRD-K13032584-001-01-5
BRD-K13032584-003-18-5
BRD-K13032584-003-19-3
BRD-K13032584-003-21-9
N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide #
4-[(2-methylhydrazinyl)methyl]-N-(propan-2-yl)benzamide
BENZAMIDE, N-(1-METHYLETHYL)-4-((2-METHYLHYDRAZINO)METHYL-
211-582-2