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Procarbazine hydrochloride

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Identification
Molecular formula
C12H19N3O.HCl
CAS number
366-70-1
IUPAC name
N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide;hydrochloride
State
State

At room temperature, procarbazine hydrochloride is in a solid state, specifically a crystalline powder form, which is stable under normal atmospheric conditions. It should be stored in a dry, cool place to prevent it from absorbing moisture and clumping together.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
117.00
Boiling point (Kelvin)
390.15
General information
Molecular weight
257.77g/mol
Molar mass
257.7660g/mol
Density
0.8569g/cm3
Appearence

Procarbazine hydrochloride is typically found as a white to pale yellow crystalline powder. It is hygroscopic, meaning it can absorb moisture from the air, which can affect its physical state if not stored properly. The powder is typically very fine and may appear clumpy if exposed to moisture.

Comment on solubility

Solubility of N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide; hydrochloride

The compound N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide; hydrochloride has notable solubility characteristics that are essential for its applications in various chemical contexts.

Generally speaking, the solubility of this compound can be influenced by several factors:

  • Polarity: The presence of polar functional groups in the structure tends to enhance solubility in polar solvents, like water.
  • Salt Form: As a hydrochloride salt, its solubility is typically increased in aqueous solutions compared to its non-salt counterpart.
  • Temperature: Increased temperature often facilitates greater solubility due to higher kinetic energy, resulting in enhanced molecular interactions.
  • pH Levels: The solubility can also be affected by the pH of the solvent environment, particularly if the compound can ionize under certain conditions.

In practical applications, one might find that:
– The compound is soluble in water, enhancing its usability in pharmaceutical formulations.
– It may exhibit variable solubility in organic solvents depending on their polarity.

In conclusion, the solubility of N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide; hydrochloride is generally favorable for a range of applications, particularly in aqueous environments, which is crucial in bioactivity scenarios.

Interesting facts

Interesting Facts about N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide; hydrochloride

N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide; hydrochloride is a compound that attracts the attention of researchers in various fields, particularly medicinal chemistry. Here are some fascinating insights:

  • Pharmaceutical Relevance: This compound is involved in research as a potential therapeutic agent. Its structure suggests that it may have unique interactions with biological systems, which could be beneficial in drug formulation.
  • Hydrazine Derivatives: The presence of the hydrazine group (2-methylhydrazino) is noteworthy. Hydrazones and related compounds have been recognized for their biological activities, including antitumor and antimicrobial properties.
  • Structure-Activity Relationship: The isopropyl substitution and benzamide framework may significantly influence the compound's pharmacokinetic properties, such as absorption and metabolism, making it an interesting subject for structure-activity relationship studies.
  • Potential Applications: Initial studies have suggested that compounds similar to this one could be explored for use in the treatment of various diseases, including cancers and infectious diseases. Understanding the mechanisms behind these effects could lead to the development of new therapeutic options.
  • Research Opportunities: Investigating N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide; hydrochloride can provide opportunities to enhance knowledge about *amides*, *hydrazines*, and their derivatives in medicinal chemistry.

In summary, N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide; hydrochloride stands out due to its intriguing structural features and potential medicinal applications. As researchers continue to study its properties, it may unlock new avenues for drug discovery and development.

Synonyms
Procarbazine hydrochloride
366-70-1
PROCARBAZINE HCl
Matulane
Nathulane
Natulan
Natunalar
MIH hydrochloride
PCB hydrochloride
Ibenzmethyzine hydrochloride
Procarbazine.HCl
Natulan hydrochloride
NSC-77213
Procarbazine (Hydrochloride)
Procarbazine chloridrate
Ibenzmethyzin hydrochloride
NCI-C01810
CCRIS 531
CHEBI:71428
UNII-XH0NPH5ZX8
Ro 4-6467/1
XH0NPH5ZX8
N-isopropyl-4-((2-methylhydrazinyl)methyl)benzamide hydrochloride
EINECS 206-678-6
NSC 77213
p-(N'-Methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride
DTXSID3021190
AI3-50844
RO-4-6467 HYDROCHLORIDE
NSC77213
NCI-C 01810
NCI-C-01810
1-(p-Isopropylcarbamoylbenzyl)-2-methylhydrazine hydrochloride
1-Methyl-2-(p-isopropylcarbamoylbenzyl)hydrazine hydrochloride
1-Methyl-2-p-(isopropylcarbamoyl)benzohydrazine hydrochloride
MFCD00072082
N-Isopropyl-p-(2-methylhydrazinomethyl)benzamide hydrochloride
MBH
2-(p-(Isopropylcarbamoyl)benzyl)-1-methylhydrazine hydrochloride
N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride
366-70-1 (HCl)
Procarbazine Monohydrochloride
Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-, monohydrochloride
Ro 4 6467/1
DTXCID001190
N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide monohydrochloride
p-Toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, hydrochloride
Procarbazine hydrochloride (Matulane)
Ro-46467/1
Procarbazine hydrochloride [USAN:USP:JAN]
Chlorhydrate de 1-methyl 2 p (isopropylcarbamoyl)benzyl-hydrazine
N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide hydrochloride
p-Toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, monohydrochloride
Natulanar
IBZ
N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide hydrochloride
PROCARBAZINE HYDROCHLORIDE (IARC)
PROCARBAZINE HYDROCHLORIDE [IARC]
PROCARBAZINE HYDROCHLORIDE (MART.)
PROCARBAZINE HYDROCHLORIDE [MART.]
PROCARBAZINE HYDROCHLORIDE (USP-RS)
PROCARBAZINE HYDROCHLORIDE [USP-RS]
Procarbazine hydrochloride (USAN:USP:JAN)
PROCARBAZINE HYDROCHLORIDE (USP MONOGRAPH)
PROCARBAZINE HYDROCHLORIDE [USP MONOGRAPH]
NCGC00016438-01
CAS-366-70-1
Ro-4-6467/1
SR-01000763375
Matulane (TN)
N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide hydrochloride
Procarbazini hydrochloridum
Hydrochloride, Procarbazine
Chlorhydrate de 1-methyl 2 p (isopropylcarbamoyl)benzyl-hydrazine [French]
SCHEMBL4012
MLS001401414
p-Toluamide, monohydrochloride
Monohydrochloride, Procarbazine
NSC-77213 HCl
CHEMBL1200410
HMS1571O06
BCP02880
Procarbazine hydrochloride (Natulan)
Tox21_110439
Tox21_302318
4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide;hydrochloride
BDBM50247906
HY-13733R
s1995
WLN: 1Y1&MVR D1MM1 &GH
Procarbazine HCl - Bio-X trade mark
4-[(2-methylhydrazin-1-yl)methyl]-N-(propan-2-yl)benzamide hydrochloride
AKOS015895395
N-(1-methylethyl)-4-((2-methylhydrazino)methyl)benzamide monohydrochloride
Tox21_110439_1
CCG-100985
FP27166
NC00235
Procarbazine hydrochloride (JP18/USP)
PROCARBAZINE HYDROCHLORIDE [MI]
Procarbazine (Hydrochloride) (Standard)
PROCARBAZINE HYDROCHLORIDE [JAN]
NCGC00016438-04
NCGC00255389-01
PROCARBAZINE HYDROCHLORIDE [USAN]
AC-12163
AS-13285
BP164298
HY-13733
PROCARBAZINE HYDROCHLORIDE [VANDF]
Ro 4-646711
SMR000469151
BCP0726000264
PROCARBAZINE HYDROCHLORIDE [WHO-DD]
PROCARBAZINE HYDROCHLORIDE [WHO-IP]
DB-048987
Procarbazine hydrochloride, >=98% (HPLC)
NS00079410
P2550
C07376
D00478
EN300-122365
PROCARBAZINE HYDROCHLORIDE [ORANGE BOOK]
PROCARBAZINI HYDROCHLORIDUM [WHO-IP LATIN]
SR-01000763375-4
Q26840941
Z1541759748
(P-N'-(1-METHYLHYDRAZINOMETHYL)-N-ISOPROPYL) BENZAMIDE
N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine Hydrochloride
methyl-[[4-(propan-2-ylcarbamoyl)phenyl]methylamino]azanium;chloride
N-isopropyl-4-((2-methylhydrazinyl)methyl)benzamidehydrochloride
1-METHYL-2-(P-(ISOPROPYLCARBAMOYL)BENZYL)HYDRAZINE HYDROCHLORIDE
1-METHYL-2-P-(ISOPROPYLCARBAMOYL)BENZYLHYDRAZINE HYDROCHLORIDE
4-[(2-methyl-hydrazino)-methyl]-benzoic acid isopropylamide hydrochloride
N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride
benzamide, N-(1-methylethyl)-4-((2-methylhydrazino) methyl)-, monohydrochloride
N-ISOPROPYL-.ALPHA.-(2-METHYLHYDRAZINO)-P-TOLUAMIDE MONOHYDROCHLORIDE
Procarbazine hydrochloride, United States Pharmacopeia (USP) Reference Standard
206-678-6
N-(1-Methylethyl)-4-(2-methylhydrazino)methylbenzamide hydrochloride;N-Isopropyl-(2-methylhydrazino)-p-toluamide-hydrochloride;M
N-(1-Methylethyl)-4-[(2-methylhydrazino)methyl]benzamide hydrochloride;N-Isopropyl-(2-methylhydrazino)-p-toluamide-hydrochloride;Mut ulane