Ro 11-3128 | Solubility of Things

Identification

Molecular formula

C₁₆H₁₇N₃

CAS number

55268-75-2

IUPAC name

N-isopropyl-7H-benzo[d][1,3]benzodiazepin-6-amine

State

At room temperature, Ro 11-3128 is typically in a solid state. It can be handled as a powder in laboratory settings and is stable at normal conditions. It is not volatile at room temperature, ensuring safe handling as long as it is not exposed to high temperatures.

Melting point (Celsius)

160.00

Melting point (Kelvin)

433.15

Boiling point (Celsius)

315.00

Boiling point (Kelvin)

588.15

General information

Molecular weight

263.34g/mol

Molar mass

263.3430g/mol

Density

1.2700g/cm³

Appearence

Ro 11-3128 is typically observed as a solid substance. The compound may appear as a crystalline powder or might be amorphous depending on its preparation method. Solid benzodiazepines like Ro 11-3128 often have a characteristic pale color.

Comment on solubility

Solubility of N-isopropyl-7H-benzo[d][1,3]benzodiazepin-6-amine

N-isopropyl-7H-benzo[d][1,3]benzodiazepin-6-amine is a unique compound that exhibits intriguing solubility characteristics. Understanding its solubility profile is essential for its applications in various fields, particularly pharmacology.

Key Points on Solubility:

Solvent Compatibility: The solubility of this compound in organic solvents can vary considerably. It is generally more soluble in non-polar or weakly polar solvents.
Hydrophilic vs. Hydrophobic: Its structure suggests a predominantly hydrophobic character, which may lead to low solubility in water.
pH Influence: The solubility may also depend on the pH of the solution. In acidic environments, protonation may enhance solubility due to increased polarity.
Temperature Effects: As with many organic compounds, increased temperature typically enhances solubility, allowing for better dissolution.

In summary, while N-isopropyl-7H-benzo[d][1,3]benzodiazepin-6-amine is likely to have limited aqueous solubility, its interaction with various solvents can be optimized by manipulating environmental factors such as pH and temperature. Understanding these parameters is essential for its effective application and utilization.

Interesting facts

Exploring N-isopropyl-7H-benzo[d][1,3]benzodiazepin-6-amine

N-isopropyl-7H-benzo[d][1,3]benzodiazepin-6-amine is a fascinating compound that falls under the category of benzodiazepines, which are well-known for their psychoactive effects. Here are some intriguing facts about this compound:

Medicinal Potential: Benzodiazepines, including this compound, are widely researched for their potential therapeutic applications, particularly in the fields of anxiety treatment, muscle relaxation, and sleep induction.
Synthetic Versatility: The unique structure of N-isopropyl-7H-benzo[d][1,3]benzodiazepin-6-amine allows for synthetic modifications, which can lead to different biological activities. This makes it a valuable target in medicinal chemistry.
Mechanism of Action: Like many benzodiazepines, it likely interacts with the GABA_A receptor in the brain, enhancing the inhibitory effects of GABA—this neurotransmitter is crucial for promoting calmness and relaxation.
Structure-Activity Relationship (SAR): Understanding the relationship between the structure of benzodiazepines and their biological effects is a central theme in pharmaceutical research, helping scientists design more effective and safer drugs.
Research Focus: There is ongoing research focusing on the potential of newer benzodiazepine derivatives, including variations of this compound, to minimize side effects such as dependency and withdrawal symptoms commonly associated with traditional benzodiazepines.

In conclusion, N-isopropyl-7H-benzo[d][1,3]benzodiazepin-6-amine stands at the intersection of chemistry and pharmacology, offering promises and challenges for scientists engaged in the search for effective mental health therapies. The continuous exploration of such compounds highlights the importance of innovative approaches in drug discovery.