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Sulfacetamide

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Identification
Molecular formula
C10H14N2O3S
CAS number
145-48-6
IUPAC name
N-isopropyl-N-[(4-methylsulfonylphenyl)methyl]acetamide
State
State

Sulfacetamide is typically found as a solid at room temperature. It is characterized by its crystalline structure and remains stable under standard storage conditions.

Melting point (Celsius)
182.00
Melting point (Kelvin)
455.15
Boiling point (Celsius)
283.00
Boiling point (Kelvin)
556.15
General information
Molecular weight
214.25g/mol
Molar mass
214.2510g/mol
Density
1.2560g/cm3
Appearence

Sulfacetamide typically appears as a white to off-white crystalline powder. It is often found in formulations as a fine, free-flowing powder that can be easily measured and mixed with other ingredients in pharmaceutical preparations.

Comment on solubility

Solubility of N-isopropyl-N-[(4-methylsulfonylphenyl)methyl]acetamide

The solubility of N-isopropyl-N-[(4-methylsulfonylphenyl)methyl]acetamide is a subject of great interest due to its unique chemical structure. Understanding its solubility behavior is essential for various applications in chemical research and pharmaceuticals. Here are some key points regarding its solubility:

  • Apolar Solvent Compatibility: This compound is likely to exhibit limited solubility in nonpolar solvents due to the presence of polar functional groups.
  • Polar Solvent Affinity: It may dissolve more readily in polar solvents, such as water or ethanol, due to its functional groups which can engage in hydrogen bonding.
  • Temperature Influence: Like many organic compounds, the solubility of N-isopropyl-N-[(4-methylsulfonylphenyl)methyl]acetamide can increase with temperature, following the general principle that solubility tends to rise with higher temperatures.
  • pH Sensitivity: The solubility may also vary with changes in pH, especially since some of its functional groups might be ionizable.

In summary, the solubility of N-isopropyl-N-[(4-methylsulfonylphenyl)methyl]acetamide is influenced by a variety of factors including solvent properties, temperature, and pH. Therefore, the precise solubility needs to be determined experimentally for specific applications.

Interesting facts

Interesting Facts about N-isopropyl-N-[(4-methylsulfonylphenyl)methyl]acetamide

N-isopropyl-N-[(4-methylsulfonylphenyl)methyl]acetamide is a fascinating compound that combines unique structural features with significant biological implications. Here are some noteworthy aspects to consider:

  • Pharmaceutical Potential: This compound belongs to a class of amides that has shown promise in medicinal chemistry. Its distinct structure may contribute to various therapeutic effects, making it an interesting candidate for drug development.
  • Methylsulfonyl Group Influence: The presence of the methylsulfonyl group in its structure can enhance the compound's solubility and bioavailability, which are critical factors in pharmacokinetics. This group plays an essential role in the compound's interaction with biological targets.
  • Isopropyl Moiety: The isopropyl part of the compound may be responsible for its lipophilic nature, affecting how it crosses cellular membranes and interacts with enzyme systems.
  • Structure-Activity Relationship (SAR): The unique arrangement of atoms in N-isopropyl-N-[(4-methylsulfonylphenyl)methyl]acetamide provides an excellent model for studying SAR. Understanding how slight modifications in structure can affect biological activity is vital for designing more effective pharmaceuticals.
  • Research Applications: Researchers often use this compound in studies focusing on enzyme inhibition and receptor binding assays, aiming to elucidate its mechanisms of action and potential therapeutic applications.

In summary, N-isopropyl-N-[(4-methylsulfonylphenyl)methyl]acetamide stands out due to its intriguing structural attributes and potential roles in pharmaceutical research. As a chemist or student, exploring the chemical behavior and biological implications of this compound can lead to valuable discoveries in medicinal chemistry.

Synonyms
3613-88-5
ACETAMIDE, N-ISOPROPYL-N-(p-(METHYLSULFONYL)BENZYL)-
M & B 5612
N-Isopropyl-N-(p-(methylsulfonyl)benzyl)acetamide
DTXSID60189709
DTXCID70112200
N-[(4-methylsulfonylphenyl)methyl]-N-propan-2-ylacetamide
N-Isopropyl-N-(4-(methylsulfonyl)benzyl)acetamide
N-Isopropyl-N-[4-(methylsulfonyl)benzyl]acetamide
starbld0015205
AKOS040750077