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Primaquine

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Identification
Molecular formula
C15H21N3O
CAS number
90-34-6
IUPAC name
N'-isopropyl-N-(6-methoxy-8-quinolyl)pentane-1,5-diamine
State
State

Primaquine is typically in a solid state at room temperature. It is usually administered in tablet form for medicinal purposes.

Melting point (Celsius)
208.00
Melting point (Kelvin)
481.15
Boiling point (Celsius)
382.40
Boiling point (Kelvin)
655.60
General information
Molecular weight
259.36g/mol
Molar mass
259.3610g/mol
Density
1.0650g/cm3
Appearence

Primaquine is a white to pale yellow crystalline powder. It is sparingly soluble in water and has a bitter taste.

Comment on solubility

Solubility of N'-isopropyl-N-(6-methoxy-8-quinolyl)pentane-1,5-diamine

The solubility of N'-isopropyl-N-(6-methoxy-8-quinolyl)pentane-1,5-diamine is influenced by a variety of factors including its molecular structure, polarity, and the presence of functional groups. Understanding its solubility can be essential for applications in various chemical processes.

Factors Affecting Solubility:

  • Polarity: The presence of both hydrophobic (isopropyl and pentane) and hydrophilic (methoxy and quinolyl) components in the structure affects its overall polarity, which in turn influences solubility in different solvents.
  • Hydrogen Bonding: The capability of N-H groups to form hydrogen bonds may enhance solubility in polar solvents, allowing it to interact more favorably with environments such as water.
  • Temperature: As with many compounds, increasing the temperature often increases solubility, making the compound more soluble in organic solvents upon heating.

In general, compounds containing quinoid structures often show moderate retention in water but can exhibit increased solubility in organic solvents like ethanol or dimethyl sulfoxide (DMSO). The solubility profile will greatly depend on the specific application and conditions under which the compound is being utilized.

Conducting further solubility testing under various conditions can provide valuable insights into how this compound behaves in practical scenarios.

Interesting facts

Interesting Facts about N'-isopropyl-N-(6-methoxy-8-quinolyl)pentane-1,5-diamine

N'-isopropyl-N-(6-methoxy-8-quinolyl)pentane-1,5-diamine is a fascinating chemical compound primarily due to its role in medicinal chemistry and potential therapeutic applications. Here are some key points that highlight its significance:

  • Medicinal Properties: This compound is often studied for its potential therapeutic effects, particularly in the realm of neuropharmacology. It may have implications in treating diseases related to the central nervous system.
  • Quinolyl Group: The presence of the quinolyl moiety is noteworthy; quinolines have demonstrated a wide array of biological activities. They are known for their anti-inflammatory, antimicrobial, and anticancer properties, making this compound a subject of interest in drug discovery.
  • Synthesis Challenges: The synthesis of N'-isopropyl-N-(6-methoxy-8-quinolyl)pentane-1,5-diamine involves intricate synthetic pathways that challenge chemists to develop efficient methods. This not only enhances the understanding of synthetic chemistry but also encourages innovation in chemical methodologies.
  • Structure-Activity Relationship (SAR): The evaluation of how slight variations in the compound's structure can affect its biological activity is a crucial area of research. Understanding the SAR can lead to the optimization of the compound for specific therapeutic targets.
  • Potential in Drug Development: Given its unique structure and the properties imparted by the methoxy and quinolyl groups, this compound has potential for further development into pharmaceuticals. Researchers are continually on the lookout for compounds that can treat conditions like neurodegenerative diseases.
  • Collaboration Across Disciplines: Research on such compounds necessitates collaboration among chemists, biologists, and pharmacologists, highlighting the interdisciplinary nature of modern scientific endeavors.

As a student or scientist diving into the world of chemical compounds, studying substances like N'-isopropyl-N-(6-methoxy-8-quinolyl)pentane-1,5-diamine not only enhances your knowledge but also paves the way for groundbreaking discoveries that could lead to next-generation therapeutics.

Synonyms
PENTAQUINE
86-78-2
N1-Isopropyl-N5-(6-methoxy-8-quinolyl)-1,5-pentanediamine
Pentaquina
N-(6-methoxyquinolin-8-yl)-N'-propan-2-ylpentane-1,5-diamine
MFCD00136425
NH99Y5GNF7
Pentachinum
1,5-Pentanediamine, N-(6-methoxy-8-quinolinyl)-N'-(1-methylethyl)-
WR 6021
Pentachina
Pentachina [DCIT]
Pentaquinum
Pentaquine [INN:BAN]
Pentaquinum [INN-Latin]
Pentaquina [INN-Spanish]
CCRIS 6978
UNII-NH99Y5GNF7
Pentaquin
PENTAQUINE [INN]
CHEMBL35802
SCHEMBL980723
DTXSID40235339
VKXQZROIIKPELG-UHFFFAOYSA-N
AC7022
SY248276
NS00114081
AS-1126-215
8-(5-Isopropylaminoamylamino)-6-methoxyquinoline
Q11084938
quinoline, 8-(5-isopropylamino)pentylamino-6-methoxy-
8-(5-ISOPROPYLAMINOAMYLAMINO)-6-METHOXY QUINOLINE