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Isoniazid

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Identification
Molecular formula
C6H7N3O
CAS number
54-85-3
IUPAC name
N'-isopropylpyridine-4-carbohydrazide
State
State

Isoniazid is in a solid state at room temperature.

Melting point (Celsius)
171.00
Melting point (Kelvin)
444.00
Boiling point (Celsius)
251.00
Boiling point (Kelvin)
524.00
General information
Molecular weight
137.14g/mol
Molar mass
137.1390g/mol
Density
1.2310g/cm3
Appearence

Isoniazid appears as a white crystalline powder. It may also appear as colorless crystals, which are virtually odorless.

Comment on solubility

Solubility of N'-isopropylpyridine-4-carbohydrazide

N'-isopropylpyridine-4-carbohydrazide (C6H7N3O) presents interesting solubility characteristics that are essential to understand its behavior in different solvents.

General Solubility Trends

This compound is primarily analyzed in the context of:

  • Polarity: The presence of both a hydrazide group and a pyridine ring contributes to its polar character, enhancing solubility in polar solvents.
  • Hydrogen Bonding: The capability for hydrogen bonding due to the hydrazide functionality may increase solubility in solvents that are capable of similar intermolecular interactions.
  • Hydrophobic Interactions: The isopropyl group can contribute to hydrophobic interactions, potentially limiting solubility in water but enhancing it in organic solvents.

Solvent Compatibility

Empirical studies have indicated that:

  • N'-isopropylpyridine-4-carbohydrazide is more soluble in ethanol and dimethyl sulfoxide (DMSO) compared to water.
  • Its solubility in water may be limited due to the relatively hydrophobic nature of the isopropyl group.
  • However, its solubility can vary based on temperature and the presence of other solutes or co-solvents.

In conclusion, the solubility of N'-isopropylpyridine-4-carbohydrazide can be summarized as moderate in polar solvents like ethanol while exhibiting limited solubility in water, pointing to the compound's unique dual character influenced by its structural components.

Interesting facts

Interesting Facts About N'-isopropylpyridine-4-carbohydrazide

N'-isopropylpyridine-4-carbohydrazide is a fascinating compound with various applications in synthetic chemistry and medicinal research. Here are some intriguing aspects of this molecule:

  • Structural Features: This compound contains a pyridine ring, which is known for its aromatic properties and presence in many natural products and drugs.
  • Functional Group Diversity: The presence of the hydrazide functional group makes it an important precursor in the synthesis of hydrazones, which are noteworthy for their biological activities.
  • Pharmaceutical Relevance: Such compounds have shown potential in medicinal chemistry due to their ability to interact with biological targets. This makes N'-isopropylpyridine-4-carbohydrazide a compound of interest in drug development.
  • Research Applications: Scientists often explore compounds like this for their ability to function as intermediates in the synthesis of more complex structures, showing versatility in organic synthesis.
  • Hydrazides in Action: Compounds that contain hydrazide linkages are studied for their anti-tuberculosis and anti-cancer properties, presenting avenues for therapeutic development.

As quoted by a leading researcher in organic chemistry, "The beauty of synthesis lies in the ability to create new compounds with diverse functionalities and potential impacts on health". This defines the importance of understanding molecules like N'-isopropylpyridine-4-carbohydrazide as we unlock new frontiers in chemical and biological sciences.

In summary, N'-isopropylpyridine-4-carbohydrazide not only showcases interesting structural chemistry but also serves as a potential star in the world of pharmaceuticals and organic synthesis.

Synonyms
iproniazid
54-92-2
N'-Isopropylisonicotinohydrazide
Iprazid
Iproniazide
Marsilid
Euphozid
Rivivol
Marsalid
Yatrozide
4-Pyridinecarboxylic acid, 2-(1-methylethyl)hydrazide
Iproniazida
Iproniazidum
Iproniazyd [Polish]
N'-isopropylpyridine-4-carbohydrazide
Iprazide
Iproniazyd
Ipronid
Ro 2-4572
Iproniazide [INN-French]
Iproniazidum [INN-Latin]
N'-Isopropylisonicotinoylhydrazide
Iproniazida [INN-Spanish]
1-Isonicotinoyl-2-isopropylhydrazine
Isonicotinic acid 2-isopropylhydrazide
CCRIS 9177
Ipronin
UNII-D892HFI3XA
P 887
EINECS 200-218-8
D892HFI3XA
Iproniazid (INN)
Iproniazid [INN:BAN:DCF]
BRN 0142700
Isonicotinic acid, N'-isopropyl hydrazide
N'-(propan-2-yl)pyridine-4-carbohydrazide
IPRONIAZID [MI]
IPRONIAZID [INN]
ISONICOTINIC ACID, 2-ISOPROPYLHYDRAZIDE
MFCD00153819
IPRONIAZID [WHO-DD]
CHEMBL92401
N-Isopropyl isonicotinhydrazide
CHEBI:5958
DTXSID5023168
N'-(1-methylethyl)pyridine-4-carbohydrazide
1-Isonicotinyl-2-isopropylhydrazine
4-22-00-00551 (Beilstein Handbook Reference)
Isonicotinic acid N'-isopropylhydrazide
Marsilid (TN)
Iproniazide (INN-French)
Iproniazidum (INN-Latin)
Iproniazida (INN-Spanish)
N inverted exclamation mark -Isopropylisonicotinohydrazide
Propilniazida
NSC81850
N'-propan-2-ylpyridine-4-carbohydrazide
Spectrum_000268
Prestwick0_000176
Prestwick1_000176
Prestwick2_000176
Prestwick3_000176
Spectrum2_000468
Spectrum3_000272
Spectrum4_000396
Spectrum5_001437
Lopac-I-7627
SCHEMBL4153
Lopac0_000643
BSPBio_000071
BSPBio_001744
KBioGR_000951
KBioSS_000748
DivK1c_000121
SPBio_000576
SPBio_001992
BPBio1_000079
DTXCID503168
Iproniazid - Bio-X trade mark
BDBM29136
HY-B0886A
KBio1_000121
KBio2_000748
KBio2_003316
KBio2_005884
KBio3_001244
N'-isopropylisonicotino hydrazide
NINDS_000121
GLXC-02864
HMS2090F08
HMS3886E05
N'-Isopropylisonicotinohydrazide #
s4856
AKOS006229272
CCG-204730
DB04818
DS-7371
FI63875
N'-isopropyl-pyridine-4-carbohydrazide
SDCCGSBI-0050623.P004
IDI1_000121
Isonicotinic acid N'-isopropyl-hydrazide
NCGC00015565-01
NCGC00015565-02
NCGC00015565-03
NCGC00015565-04
NCGC00015565-12
NCGC00162210-01
BI164580
CAS-305-33-9
DA-04957
P887
SY025980
SBI-0050623.P003
AB00053568
CS-0013623
NS00008980
D02579
AB00053568-12
AB00053568_13
AN-068/14539031
Q421368
BRD-K88568253-011-03-3
BRD-K88568253-011-19-9
BRD-K88568253-065-03-9
200-218-8