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Methamphetamine hydrochloride

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Identification
Molecular formula
C10H15N·HCl
CAS number
537-46-2
IUPAC name
N-methyl-1-phenyl-propan-2-amine;hydrochloride
State
State

At room temperature, Methamphetamine hydrochloride is typically found as a solid. It is well-known in drug formulations mainly as a crystalline solid, being stable and non-volatile under normal conditions.

Melting point (Celsius)
170.00
Melting point (Kelvin)
443.15
Boiling point (Celsius)
225.00
Boiling point (Kelvin)
498.15
General information
Molecular weight
203.71g/mol
Molar mass
203.7100g/mol
Density
0.9136g/cm3
Appearence

Methamphetamine hydrochloride typically appears as a white crystalline solid. It can also be seen as a fine powder, and sometimes it may have a translucent or off-white hue. The crystalline form is often compared to small shards of glass or chunky crystals.

Comment on solubility

Solubility of N-methyl-1-phenyl-propan-2-amine hydrochloride

N-methyl-1-phenyl-propan-2-amine hydrochloride, commonly referred to as a hydrochloride salt, tends to exhibit specific solubility characteristics due to its chemical structure. Understanding its solubility can be vital for various applications, including pharmaceuticals.

Key points regarding solubility:

  • Solvent Interaction: This compound is generally soluble in polar solvents such as water and alcohol.
  • Hydrochloride Form: The presence of the hydrochloride group typically enhances solubility in aqueous environments.
  • pH Influence: The solubility can vary significantly with changes in pH; it is often more soluble in acidic conditions.
  • Temperature Effect: Increasing temperature can improve dissolution rates, making the compound more soluble.

In practice, the solubility of N-methyl-1-phenyl-propan-2-amine hydrochloride can be summarized as follows: it is highly soluble in aqueous solutions, particularly in acidic mediums, which is beneficial for its use in various biochemical applications. As a rule of thumb, the higher the temperature, the greater the solubility, indicating that careful attention should be paid when formulating solutions for use in laboratory settings.

Interesting facts

Interesting Facts about N-methyl-1-phenyl-propan-2-amine; hydrochloride

N-methyl-1-phenyl-propan-2-amine; hydrochloride, commonly referred to in the scientific community as an amphetamine derivative, presents a fascinating intersection of pharmacology and chemistry. Here are some intriguing aspects of this compound:

  • Pharmaceutical Relevance: This compound has garnered attention for its role in medicine. It is often associated with treatments for Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy, showcasing its potential effects on enhancing focus and reducing fatigue.
  • Mechanism of Action: N-methyl-1-phenyl-propan-2-amine; hydrochloride functions primarily as a central nervous system stimulant. It achieves this by increasing the release of neurotransmitters such as dopamine and norepinephrine, leading to heightened alertness and energy levels.
  • Historical Context: The development of amphetamines dates back to the early 20th century, initially synthesized in 1887. However, it wasn't until the 1930s that they began to find therapeutic use, revolutionizing treatments for psychological and neurobiological disorders.
  • Potential for Misuse: While beneficial in controlling certain medical conditions, this compound has a significant potential for abuse. Understanding this duality exemplifies the balance between therapeutic benefits and risks inherent in many pharmacologically active compounds.
  • Research Pathways: Ongoing research continues to explore the various applications of this compound, including its effects on cognitive function and potential usage in managing obesity, underscoring the evolving nature of pharmacological science.

As a remarkable compound with both therapeutic benefits and associated risks, N-methyl-1-phenyl-propan-2-amine; hydrochloride serves as an excellent case study in the field of medicinal chemistry. Its dual nature poses ethical questions regarding prescription practices and public health.

Synonyms
dl-Methamphetamine hydrochloride
300-42-5
Desamine
Desoxedrine
Detrex
Des-oxa-D
dl-Desoxyephedrine hydrochloride
Methampex
Deoxyephedrine
Madrine
dl-Methamphetaminehydrochloride
dl-Deoxyephedrine hydrochloride
dl-Methamphetimine hydrochloride
dl-Methanphetamine hydrochloride
Desoxyn
Methylisomyn
Soxysympamine
Desoxyfed
Drinalfa
Efroxine
Isophen
Pervitin
Syndrox
Tonedron
Destim
DTXSID3048865
24GNZ56D62
d-Deoxyephedrine hydrochloride
Desoxyephedrine
NSC-22367
NSC-169506
4298-16-2
Amphedroxyn
Daropervamin
Desossiefedrina
Metamphetamin
Metamsustac
Methedrinal
Methylbenzedrin
Methylpropamine
Neopharmedrine
Pisichergina
Psichergina
Psiquergina
Psychergine
Semoxydrine
Amedrine
Amphedroxy
Bombita
Depoxin
Desfedran
Desfedrin
Dexophrine
Dopidrin
Doxephin
Doxephrin
Estimulex
Fenyprin
Kemodrin
Lanazine
Levetamin
METHAMPHETAMINE HYDROCHLORIDE, DL-
Methamphin
Methoxyn
Neodrine
Noradrin
Normadrine
Norodrin
Oxydess
Oxydrene
Oxydrin
Phedoxe
Phedrisox
Premodrin
Psicopan
Psykoton
Amdram
d,l-Methamphetamine.HCl
Oxyfed
(.+-.)-Madrine
Miller drine
Dee -5
N-methyl-1-phenylpropan-2-amine;hydrochloride
methyl(1-phenylpropan-2-yl)amine hydrochloride
Dee -10
Mepho-D
Benzeneethanamine, N,a-dimethyl-, hydrochloride
Methylamphetamine hydrochloride
rac-Methamphetamine Hydrochloride
WLN: 1MY1R &GH -R
DEA oxo-5
(.+-.)-Methamphetamine hydrochloride
NSC 22367
NSC 169506
(+/-)-Methamphetamine-d5 hydrochloride
(+-)-Methamphetamine hydrochloride
Benzeneethanamine, N,alpha-dimethyl-, hydrochloride
D,L-Methamphetamine HCl
Methamphetamine hydrochloride, (dl)
NCGC00247330-02
EINECS 206-093-6
EINECS 224-306-0
dl-N-Methyl-.beta.-phenylisopropylamine hydrochloride
(+-)-N-Methylamphetamine hydrochloride
Phenethylamine,.alpha.-dimethyl-, hydrochloride, (.+-.)-
rac Methamphetamine Hydrochloride (1.0mg/ml in Methanol)
Deoxyphedrine
Methedrine
914F
Benzeneethanamine,.alpha.-dimethyl-, hydrochloride, (.+-.)-
UNII-24GNZ56D62
N,alpha-Dimethylphenethylamine hydrochloride
R-(-)-Methamphetamine Hydrochloride
NSC169505
C 6379
(+/-)-Methamphetamine Hydrochloride
Dexoval hydrochloride
Desyphed hydrochloride
Efroxine hydrochloride
N-Methyl-beta-phenylisopropylaminhydrochlorid [German]
2747917-87-7
Usaf el-36
N-Methyl-beta-phenylisopropylaminhydrochlorid
N-methyl-1-phenylpropan-2-amine hydrochloride
Benzeneethanamine,.alpha.-dimethyl-, (S)-
Phenethylamine, N,alpha-dimethyl-, hydrochloride
(+)-Methaphetamine chloride
SCHEMBL42098
WLN: 1MY1R &GH
2-METHYLAMINO-1-PHENYLPROPANE HYDROCHLORIDE
MLS002320675
Phenethylamine,.alpha.-dimethyl-, (S)-(+)-
DTXCID305544
(+)-Metamphetamine hydrochloride
(+)-Methaphetamine hydrochloride
TWXDDNPPQUTEOV-UHFFFAOYSA-N
DL-methamphetamine-d5 hydrochloride
KCA12481
NSC22367
UYB80548
Tox21_112857
NSC169506
(+)-N-Methylamphetamine hydrochloride
FM25139
METAMFETAMINE HYDROCHLORIDE, DL-
(DL)-METHAMPHETAMINE HYDROCHLORIDE
CAS-300-42-5
SMR001338821
NS00079507
(+/-)-Methamphetamine (hydrochloride) (CRM)
(+/-)-N-METHYLAMPHETAMINE HYDROCHLORIDE
(?R)-N,?-Dimethylbenzeneethanamine hydrochloride
D-N,.alpha.-Dimethylphenethylamine hydrochloride
(+)-N,.alpha.-Dimethylphenethylamine hydrochloride
D-N-Methyl-.beta.-phenylisopropylamine hydrochloride
Benzeneethanamine, N,.alpha.-dimethyl-, hydrochloride
N,.ALPHA.-DIMETHYLPHENETHYLAMINE HYDROCHLORIDE
Q27253854
Benzeneethanamine,.alpha.-dimethyl-, hydrochloride, (S)-
PHENETHYLAMINE, N,.ALPHA.-DIMETHYL-, HYDROCHLORIDE
Phenethylamine,.alpha.-dimethyl-, hydrochloride, (S)-(+)-
d,l-Methamphetamine.HCl, 1mg/ml in Methanol (as free base)
BENZENEETHANAMINE, N,.ALPHA.-DIMETHYL-, HYDROCHLORIDE (1:1)