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Memantine hydrochloride

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Identification
Molecular formula
C12H21N • 2HCl
CAS number
41100-52-1
IUPAC name
N-methyl-3-[3-(methylamino)-1-adamantyl]adamantan-1-amine;dihydrochloride
State
State

At room temperature, Memantine hydrochloride is in a solid state, specifically forming a crystalline powder. It is stable under normal conditions and does not sublimate or decompose easily.

Melting point (Celsius)
292.00
Melting point (Kelvin)
565.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
215.34g/mol
Molar mass
215.3440g/mol
Density
1.0800g/cm3
Appearence

Memantine hydrochloride typically appears as a white to off-white crystalline powder. The compound is stable and non-hygroscopic, meaning it does not readily absorb moisture from the air.

Comment on solubility

Solubility of N-methyl-3-[3-(methylamino)-1-adamantyl]adamantan-1-amine; dihydrochloride

N-methyl-3-[3-(methylamino)-1-adamantyl]adamantan-1-amine; dihydrochloride, with its complex structure, exhibits noteworthy solubility characteristics. This compound is typically categorized as a salt, stemming from the presence of the dihydrochloride component. Salts generally have unique solubility behaviors compared to their parent free bases.

The solubility of this compound can be summarized with the following points:

  • Sensitive to pH: The solubility tends to increase in acidic conditions due to protonation of the amine groups.
  • Aqueous Solubility: This compound is likely to dissolve well in water, as ionic compounds usually display higher solubility in polar solvents.
  • Temperature Dependency: Like many salts, higher temperatures may enhance solubility, although the specific temperature dependence requires empirical data for confirmation.
  • Organic Solvents: Its solubility in non-polar organic solvents may be limited due to the ionic nature of the compound.

In summary, while the dihydrochloride form implies good solubility in water, the efficiency of this solubility will also depend significantly on the surrounding conditions, particularly pH and temperature. Further empirical studies could provide more insights into specific solubilities under varying conditions.

Interesting facts

Interesting Facts About N-methyl-3-[3-(methylamino)-1-adamantyl]adamantan-1-amine; Dihydrochloride

N-methyl-3-[3-(methylamino)-1-adamantyl]adamantan-1-amine; dihydrochloride is a fascinating compound that has attracted attention in the field of medicinal chemistry. Here are some key points that highlight its significance:

  • Unique Structure: This compound is a derivative of adamantane, characterized by its rigid three-dimensional structure. This unique architecture contributes to its potential activity as a pharmaceutical agent.
  • Pharmacological Potential: Research has suggested that compounds similar to this one may exhibit activity against certain neurodegenerative diseases and could play roles in modulating the central nervous system.
  • Research Applications: The compound is of particular interest in studies related to drug design and development, especially in understanding how modifications to the adamantane core can influence biological activity.
  • Analytical Techniques: Scientists often employ advanced techniques such as NMR (Nuclear Magnetic Resonance) spectroscopy and mass spectrometry to study the properties and behaviors of this compound, providing insights into its molecular interactions.
  • Safety and Toxicology: As with any chemical compound, understanding its safety profile is paramount. Researchers conduct extensive toxicological assessments to ensure safe applications in potential therapeutic contexts.

Overall, N-methyl-3-[3-(methylamino)-1-adamantyl]adamantan-1-amine; dihydrochloride is a prime example of how intricate chemistry can lead to discoveries that may one day benefit human health. As emphasized by chemists, “The structure defines the function,” and this compound serves as a testament to that principle!

Synonyms
18392-96-6
N,N'-Dimethyl-1,1,'-biadamantane-3,3'-diamine dihydrochloride
1,1'-BIADAMANTANE-3,3'-DIAMINE, N,N'-DIMETHYL-, DIHYDROCHLORIDE
DTXSID50939775
N~3~,N~3'~-Dimethyl[1,1'-bi(tricyclo[3.3.1.1~3,7~]decane)]-3,3'-diamine--hydrogen chloride (1/2)