Amitriptyline | Solubility of Things

Identification

Molecular formula

C₂₀H₂₃N

CAS number

50-48-6

IUPAC name

N-methyl-3-(5-methyl-6,11-dihydrobenzo[c][1]benzazepin-11-yl)propan-1-amine

State

In its purified form, amitriptyline is a solid at room temperature.

Melting point (Celsius)

198.00

Melting point (Kelvin)

471.00

Boiling point (Celsius)

392.70

Boiling point (Kelvin)

665.85

General information

Molecular weight

277.40g/mol

Molar mass

277.4030g/mol

Density

1.0085g/cm³

Appearence

Amitriptyline is typically found as white or almost white crystalline powders.

Comment on solubility

Solubility of N-methyl-3-(5-methyl-6,11-dihydrobenzo[1]benzazepin-11-yl)propan-1-amine

The solubility of N-methyl-3-(5-methyl-6,11-dihydrobenzo[1]benzazepin-11-yl)propan-1-amine is dependent on several factors, including its chemical structure and the solvent used. Here are some key points to consider:

Polar vs. Non-polar Solvents: The compound’s structure suggests it may exhibit amphiphilic characteristics, enhancing its solubility in both polar and non-polar solvents.
Hydrogen Bonding: The presence of amine groups may allow for hydrogen bonding with water molecules, potentially increasing its solubility in aqueous environments.
Structural Complexity: Due to its intricate structure, solubility can vary significantly with the presence of substituents that may impede or facilitate interaction with solvents.
Temperature Effects: The solubility is likely to change with temperature; typically, increased temperature may enhance the solubility of organic compounds.
pH Sensitivity: The solubility might also be affected by the pH of the solution, as ionization of the amine group can influence its solubility properties.

In summary, while there is no definitive data available regarding the solubility of this specific compound, it is essential to consider these factors in predicting its behavior in various solvents. Always consult empirical data when possible for precise solubility information.

Interesting facts

Interesting Facts About N-methyl-3-(5-methyl-6,11-dihydrobenzo[c][1]benzazepin-11-yl)propan-1-amine

N-methyl-3-(5-methyl-6,11-dihydrobenzo[c][1]benzazepin-11-yl)propan-1-amine is a fascinating compound that belongs to a class of chemical compounds known as amines. Below are some engaging aspects of this compound:

Structure and Complexity: The structure of this compound is quite intricate, featuring a bicyclic system that contributes to its unique biological properties. Its multi-ring configuration makes it a subject of interest in medicinal chemistry.
Biological Activity: Compounds similar to this one have been investigated for their potential pharmacological activities, including effects on the central nervous system. Understanding how these compounds interact with biological systems can lead to advancements in drug development.
Syntheses: The synthesis of N-methyl-3-(5-methyl-6,11-dihydrobenzo[c][1]benzazepin-11-yl)propan-1-amine can involve various reaction pathways, showcasing helpful synthetic strategies in organic chemistry. Techniques such as cyclization and functionalization are often used to construct such complex molecules.
Applications in Research: This compound can serve as a valuable tool in the study of neuropharmacology and may lead researchers to discover novel treatments for psychiatric disorders. The specific structural features may contribute to its affinity for certain receptor sites.
Historical Significance: The exploration of benzazepines dates back several decades, and their continued relevance in modern chemistry highlights their importance. Researchers are still uncovering how these compounds can influence various biological processes.

In summary, N-methyl-3-(5-methyl-6,11-dihydrobenzo[c][1]benzazepin-11-yl)propan-1-amine encapsulates a rich tapestry of chemistry that bridges structural complexity, potential biological impact, and innovative research avenues. The continuous investigation into such compounds signifies the ever-evolving nature of chemical sciences.