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Promazine

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Identification
Molecular formula
C17H20N2S
CAS number
58-40-2
IUPAC name
N-methyl-3-phenothiazin-10-yl-propan-1-amine
State
State

At room temperature, promazine exists as a solid. It is known for being stable under normal conditions of use and storage but should be kept away from light to prevent degradation.

Melting point (Celsius)
116.00
Melting point (Kelvin)
389.15
Boiling point (Celsius)
383.50
Boiling point (Kelvin)
656.65
General information
Molecular weight
284.42g/mol
Molar mass
284.4170g/mol
Density
1.2103g/cm3
Appearence

Promazine is typically found as a white to off-white crystalline powder. It is known for its light sensitivity and can change color when exposed to light over time.

Comment on solubility

Solubility of N-methyl-3-phenothiazin-10-yl-propan-1-amine

N-methyl-3-phenothiazin-10-yl-propan-1-amine exhibits varying degrees of solubility that can be influenced by several factors, including temperature and the solvent used. Typically, this compound demonstrates:

  • Moderate solubility in polar solvents: Due to its amine functional group, it often dissolves well in water and alcohols.
  • Limited solubility in nonpolar solvents: Organic solvents that lack polarity, such as hexane, may not effectively dissolve this compound.
  • Temperature sensitivity: As with many organic compounds, increasing the temperature can enhance solubility. This phenomenon is particularly evident when dissolving in polar solvents.

It is noteworthy to mention that pH can also play a critical role in the solubility of amines. In acidic environments, amines become protonated, increasing their solubility due to the formation of cationic species. Conversely, in neutral to basic conditions, the compound may exhibit lower solubility.

In summary, the solubility characteristics of N-methyl-3-phenothiazin-10-yl-propan-1-amine provide an interesting example of how molecular structure and environmental conditions interplay to affect the dissolution of chemical compounds.

Interesting facts

Interesting Facts about N-methyl-3-phenothiazin-10-yl-propan-1-amine

N-methyl-3-phenothiazin-10-yl-propan-1-amine is an intriguing compound with several noteworthy characteristics that make it particularly interesting in the field of chemistry and medicinal research.

Key Highlights:

  • Pharmacological Importance: This compound belongs to a class of compounds known as Phenothiazines, which have been widely studied for their psychotropic effects. Many derivatives of Phenothiazines are used as antipsychotic medications.
  • Structure-Activity Relationship: The unique structure of N-methyl-3-phenothiazin-10-yl-propan-1-amine allows for a variety of potential interactions with biological targets, making it a valuable compound in drug design.
  • Mechanism of Action: Compounds like N-methyl-3-phenothiazin-10-yl-propan-1-amine often act as antagonists at dopamine receptors, which is a common mechanism for antipsychotic drugs.
  • Research Potential: Ongoing studies on compounds in this class explore their efficacy and safety profiles, which could lead to the development of new therapeutics for mental health disorders.
  • Environmental Insights: The synthesis and degradation pathways of this compound can offer insights into the environmental chemistry of pharmaceuticals, helping to understand how such compounds interact in ecosystems.

In summary, N-methyl-3-phenothiazin-10-yl-propan-1-amine exemplifies how organic compounds can have profound implications in medicine and environmental science. The continued exploration of its properties could pave the way for new innovations in pharmaceutical chemistry.

Synonyms
2095-20-7
Desmonomethylpromazine
W2SJ5WR9AK
DEMETHYLPROMAZINE
10H-Phenothiazine-10-propanamine, N-methyl-
DTXSID60175127
DTXCID5097618
Norpromazine
METHYL[3-(10H-PHENOTHIAZIN-10-YL)PROPYL]AMINE
N-methyl-3-phenothiazin-10-ylpropan-1-amine
N-Desmethylpromazine
CHEMBL38659
DESMETHYLPROMAZINE
UNII-W2SJ5WR9AK
MONODEMETHYLPROMAZINE
MONODESMETHYLPROMAZINE
SCHEMBL10052731
CHEBI:187276
WOCOVPRTRIBGFZ-UHFFFAOYSA-N
CAA09520
BDBM50408503
10-(3-methylaminopropyl)phenothiazine
AKOS010646689
10-(3-Methylaminopropyl)-phenothiazin
AT24526
CCG-356166
NS00115922
EN300-155284
N-methyl-3-(10H-phenothiazin-10-yl)propan-1-amine
N-METHYL-3-PHENOTHIAZIN-10-YL-PROPAN-1-AMINE
Z815273094