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Tacrine

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Identification
Molecular formula
C13H14N2
CAS number
321-64-2
IUPAC name
N-methyl-5,6,7,8-tetrahydroacridin-1-amine
State
State

At room temperature, tacrine is in a solid state, usually in the form of a crystalline powder.

Melting point (Celsius)
198.00
Melting point (Kelvin)
471.15
Boiling point (Celsius)
235.00
Boiling point (Kelvin)
508.15
General information
Molecular weight
198.27g/mol
Molar mass
198.2670g/mol
Density
1.2100g/cm3
Appearence

Tacrine is typically found as a pale yellow or off-white crystalline powder. It is sensitive to light and should be stored protected from light to prevent degradation.

Comment on solubility

Solubility of N-methyl-5,6,7,8-tetrahydroacridin-1-amine

N-methyl-5,6,7,8-tetrahydroacridin-1-amine, known for its intriguing molecular structure, exhibits distinct solubility characteristics influenced by its functional groups and overall polarity.

The solubility of this compound can be analyzed based on the following factors:

  • Polarity: The presence of amine groups generally promotes interactions with polar solvents like water, enhancing solubility in these media.
  • Hydrophobic Regions: However, the hydrophobic nature due to the acridine structure may limit its solubility in highly polar solvents.
  • Solvent Effects: It tends to be more soluble in organic solvents such as ethanol and acetone, which can stabilize the compound’s structure.
  • pH Dependency: The solubility might also vary with pH, wherein acidic or basic conditions alter the protonation state of the amine group impacting solubility.

In summary, while N-methyl-5,6,7,8-tetrahydroacridin-1-amine shows enhanced solubility in organic solvents, its behavior in water is complex and largely dependent on the environmental conditions. As with many organic compounds, the interplay between its hydrophobic and hydrophilic properties determines its overall solubility profile.

Interesting facts

N-methyl-5,6,7,8-tetrahydroacridin-1-amine

N-methyl-5,6,7,8-tetrahydroacridin-1-amine is a fascinating compound that has garnered interest in various fields of research, especially within medicinal chemistry and neuropharmacology. This compound is often noted for its structural parallels with other biologically active molecules, allowing it to serve as a useful scaffold in drug design.

Interesting Facts:

  • Potential Therapeutic Uses: Research has suggested that this compound might be beneficial in the treatment of neurological conditions, including Alzheimer's disease, due to its ability to enhance cholinergic function.
  • Structure-Activity Relationship: Its unique tetrahydroacridine structure contributes to various interactions with neurotransmitter systems, making it a subject of study for understanding drug-receptor dynamics.
  • Research Breakthroughs: Studies have shown that modifications to the N-methyl group can significantly influence the compound's biological activity, highlighting the importance of subtle structural changes.
  • Synthesis Routes: The synthesis of N-methyl-5,6,7,8-tetrahydroacridin-1-amine often involves complex organic reactions, showcasing the challenges and creativity involved in organic synthesis.
  • Cognitive Enhancer: Preliminary studies indicate that this compound may act as a cognitive enhancer, paving the way for further research into its potential nootropic effects.

As research continues, N-methyl-5,6,7,8-tetrahydroacridin-1-amine may provide important insights into drug design and the treatment of neurodegenerative diseases. The future is bright for this compound, and it may one day lead to innovative therapies that improve the quality of life for patients suffering from chronic neurological conditions.

Synonyms
NSC 172174
BRN 0476308
1,2,3,4-Tetrahydro-N-methyl-9-acridinamine
9-Amino-10-methyl-1,2,3,4-tetrahydroacridine
9-ACRIDINAMINE, 1,2,3,4-TETRAHYDRO-N-METHYL-
9-AMTA
9-amino-10-methyl-1,2,3,4-tetrahydroacridinium chloride