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Colchicine

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Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
N-methyl-N-(1-methylprop-2-ynyl)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide
State
State

At room temperature, colchicine is in a solid state.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
399.44g/mol
Molar mass
399.4370g/mol
Density
1.2122g/cm3
Appearence

Colchicine appears as a pale yellow powder or crystals. The crystals have a specific, visual form often described under microscopes. When pure, it's typically transparent and might show slight shimmer due to its crystalline nature.

Comment on solubility

Solubility of N-methyl-N-(1-methylprop-2-ynyl)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide

The solubility of N-methyl-N-(1-methylprop-2-ynyl)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide can be considered in various solvents and conditions. Understanding solubility is essential for predicting the behavior of compounds in different environments, especially in pharmacology and organic chemistry.

Key factors influencing solubility include:

  • Molecular polarity: The presence of polar functional groups can enhance solubility in polar solvents like water.
  • Temperature: Increasing temperature often increases solubility, allowing more of the compound to dissolve.
  • Solvent interaction: The compatibility and interaction of the compound with the solvent significantly influence solubility. For instance, organic solvents may dissolve organic compounds more effectively than water.

The compound's structure suggests potential solubility in non-polar to moderately polar solvents, due to its bulky aromatic rings and aliphatic chains. Additionally, the presence of multiple methoxy groups implies some degree of interaction with polar solvents, albeit less pronounced. As a result:

It may exhibit the following solubility properties:

  • Moderate solubility in organic solvents such as dichloromethane or ethanol.
  • Poor solubility in highly polar solvents like water due to hydrophobic regions.
  • Potential better solubility in mixtures of polar and non-polar solvents.

Conclusion: Further empirical testing in various solvents would provide more precise solubility data, essential for applications in synthesis and formulation.

Interesting facts

Exploring N-methyl-N-(1-methylprop-2-ynyl)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide

N-methyl-N-(1-methylprop-2-ynyl)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide, a complex compound with various functional groups, has garnered attention due to its potential applications in medicinal chemistry. Here are some fascinating aspects of this compound:

  • Diverse Functional Groups: This compound showcases multiple functional groups, including an amide, alkyne, and methoxy substituents, contributing to its unique reactivity and solubility profile.
  • Biological Relevance: Compounds with similar structures are often investigated for their biological activity, particularly in areas such as anti-cancer and anti-inflammatory research.
  • Synthetic Pathways: The synthesis of this compound may involve intriguing organic reactions, such as cross-coupling and nucleophilic substitutions, providing valuable learning opportunities for chemistry students.
  • Applications in Drug Development: Understanding the interactions of this compound with biological systems can lead to the development of novel pharmaceuticals, allowing scientists to explore new avenues for improving human health.

In summary, the study of N-methyl-N-(1-methylprop-2-ynyl)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide highlights the intricate relationship between structure and function in chemistry. Researchers and students alike are intrigued by the challenges and rewards of exploring such multifaceted compounds.