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Colchicine

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Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
N-methyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
State
State

At room temperature, colchicine is typically in a solid state.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
352.00
Boiling point (Kelvin)
625.15
General information
Molecular weight
399.44g/mol
Molar mass
399.4390g/mol
Density
1.2200g/cm3
Appearence

Colchicine appears as a white to pale yellow crystalline powder. It is hydroscopic and may appear in large, lustrous crystals.

Comment on solubility

Solubility of N-methyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

The solubility of the compound N-methyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide is an intriguing topic considering its complex structure. Several factors influence its solubility, which can be summarized as follows:

  • Molecular Structure: The presence of multiple methoxy groups contributes to polar functional groups, which can enhance solubility in polar solvents.
  • Hydrophobic Regions: The aromatic portions of the molecule may create hydrophobic characteristics, leading to lower solubility in aqueous environments.
  • pH Dependence: The solubility can vary with pH; under different pH conditions, ionization may occur, affecting the solubility profile.
  • Temperature Effects: Increasing temperature typically improves the solubility of organic compounds due to enhanced molecular motion.

In summary, the solubility behavior of this compound is complex and requires consideration of both polar and non-polar interactions. As noted in literature, "the solubility can greatly vary with the solvent used, highlighting the importance of solvent selection in experimental design." Understanding these solubility parameters is crucial for applications in pharmacology and material science, among other fields.

Interesting facts

Interesting Facts about N-methyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

N-methyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide is a fascinating compound that showcases the complexity and beauty of organic chemistry. Here are some noteworthy aspects of this remarkable molecule:

  • Unique Structure: The compound features a benzo[a]heptalene core, a structure known for its aromatic properties and intriguing bicyclic nature. This architecture contributes to its potential reactivity and biological activity.
  • Functional Groups: The presence of multiple methoxy groups significantly influences the compound's chemical behavior, enhancing solubility in various organic solvents and possibly affecting its interaction with biological targets.
  • Pharmacological Potential: Compounds with similar structures often show promise in drug development due to their potential interactions with specific biological pathways. Investigating the biological activity of this compound could reveal therapeutic applications.
  • Stereochemistry: The specific stereochemistry indicated by the (7S) configuration suggests the compound's spatial arrangement plays a crucial role in its properties and potential biological activity, opening avenues for chiral synthesis research.

This compound emphasizes the balance between complexity and functionality in chemical design. As we dive deeper into its synthesis and applications, we can only speculate the contributions it may offer to the fields of medicinal chemistry and materials science.


Quote to Consider: "The molecules we study are more than just entities; they are keys to unlocking the mysteries of nature."

Synonyms
N-Methylcolchicine
7336-40-5
COLCHICINE, N-METHYL-
N-Acetylcolchamine
N-Acetyldemecolcine
N-methyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
N-Acetylcolcemid
NSC 403155
BRN 2825013
Acetamide, N-methyl-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-
NSC403155
Acetamide, N-methyl-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-
CHEMBL89261
DTXSID50223606
FS-7403
NSC-403155
DA-76223
N-methyl-N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0(2),?]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide