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N-Methyl-N-phenylacetamide

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Identification
Molecular formula
C10H13NO
CAS number
611-74-5
IUPAC name
N-methyl-N-phenyl-acetamide
State
State

At room temperature, N-Methyl-N-phenylacetamide can exist as a liquid or a crystalline solid depending on its precise conditions of purity and ambient temperature.

Melting point (Celsius)
34.00
Melting point (Kelvin)
307.15
Boiling point (Celsius)
264.00
Boiling point (Kelvin)
537.15
General information
Molecular weight
149.19g/mol
Molar mass
149.1880g/mol
Density
1.0463g/cm3
Appearence

N-Methyl-N-phenylacetamide is a colorless to pale yellow liquid or crystalline solid. It has a faint aromatic odor.

Comment on solubility

Solubility of N-methyl-N-phenyl-acetamide

N-methyl-N-phenyl-acetamide, with the chemical formula C10H13NO, exhibits interesting solubility characteristics in various solvents. Understanding its solubility can help in many practical applications.

Key Points about Solubility:

  • Solvent Compatibility: N-methyl-N-phenyl-acetamide is generally soluble in organic solvents such as ethanol, dichloromethane, and acetone.
  • Water Solubility: This compound has limited solubility in water, primarily due to its hydrophobic aromatic ring which hinders its interaction with water molecules.
  • Temperature Dependency: Solubility can vary with temperature increases, often enhancing the dissolution in organic solvents.

Due to its unique structure, one can observe that:

  1. The presence of both non-polar and polar functional groups influences its solubility profile.
  2. The ability to form hydrogen bonds with polar solvents enhances solubility, albeit modestly.
  3. Overall, the aromatic portion of the molecule plays a significant role in solubility behavior.

In summary, while N-methyl-N-phenyl-acetamide is considerably soluble in organic solvents, its limited water solubility suggests caution should be exercised when considering aqueous environments for its application.

Interesting facts

Interesting Facts about N-methyl-N-phenyl-acetamide

N-methyl-N-phenyl-acetamide is an intriguing compound with various applications and properties that capture the interest of chemists and students alike. Let’s delve into some fascinating aspects of this compound:

  • Versatile Chemical Intermediate: This compound is frequently used as an intermediate in the synthesis of other chemical compounds, particularly in pharmaceuticals. Its structure allows for various modifications, making it a valuable building block in organic synthesis.
  • Role in Medicinal Chemistry: N-methyl-N-phenyl-acetamide is believed to play a role in developing analgesic and anti-inflammatory drugs. Researchers appreciate its potential in drug development, particularly in enhancing efficacy and reducing side effects.
  • Understanding Structure-Activity Relationships: The compound's unique structure facilitates the study of structure-activity relationships (SAR) in medicinal chemistry. Scientists can analyze how changes in the compound’s structure can influence biological activity.
  • Improved Solvent Properties: This compound exhibits excellent solvent properties, making it suitable for various industrial applications, particularly in the paint and coatings industry where it enhances the solubility of other materials.
  • Research Opportunities: Due to its interesting chemical properties and biological activities, N-methyl-N-phenyl-acetamide is a focal point for research on drug resistance and formulation studies in medicinal contexts.

Overall, N-methyl-N-phenyl-acetamide is a compounds that not only serves practical purposes but also sparks inquiries into its chemical behavior and potential applications in various fields, making it a topic of continual study and interest in the scientific community.

Synonyms
N-Methylacetanilide
N-Methyl-N-phenylacetamide
579-10-2
Methylazol
Methylantifebrin
Acetomethylanilide
Exalgin
Oxalgin
Acetamide, N-methyl-N-phenyl-
Phenylmethylacetamide
ACETANILIDE, N-METHYL-
N-Acetyl-methylaniline
N-Acetyl-N-methylaniline
NSC 2140
EINECS 209-436-8
BRN 2207686
6MR085F8DW
AI3-05816
NSC-2140
METHYLACETANILIDE, N-
DTXSID8060373
N-METHYLACETANILIDE [MI]
DTXCID7042279
209-436-8
MFCD00026181
N-methyl-N-phenyl-acetamide
UNII-6MR085F8DW
n-methyl-acetanilide
N-Acetylmethylaniline
aniline, N-acetyl-N-methyl-
SCHEMBL208445
WLN: 1VN1&R
CHEMBL481312
NSC2140
AC9550
AKOS006229545
LS-13627
SY053096
CS-0155055
M0134
NS00005621
EN300-6769057
AD-266/40232951
Q27265173
Z31506242
InChI=1/C9H11NO/c1-8(11)10(2)9-6-4-3-5-7-9/h3-7H,1-2H