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Dothiepin

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Identification
Molecular formula
C19H21NS
CAS number
113-53-1
IUPAC name
N-methyl-N-prop-2-ynyl-2,3,4,5-tetrahydro-1-benzothiepin-5-amine
State
State

Dothiepin is typically found as a solid at room temperature.

Melting point (Celsius)
151.50
Melting point (Kelvin)
424.70
Boiling point (Celsius)
580.30
Boiling point (Kelvin)
853.50
General information
Molecular weight
297.45g/mol
Molar mass
297.8480g/mol
Density
1.1300g/cm3
Appearence

Dothiepin typically presents as a crystalline powder. It is often prepared in its hydrochloride salt form, which is generally white or off-white.

Comment on solubility

Solubility of N-methyl-N-prop-2-ynyl-2,3,4,5-tetrahydro-1-benzothiepin-5-amine

The solubility of N-methyl-N-prop-2-ynyl-2,3,4,5-tetrahydro-1-benzothiepin-5-amine is a topic of considerable interest. Understanding how well this compound dissolves is essential for many applications, particularly in pharmaceuticals and chemical research. While specific solubility values may vary, some general points can be highlighted:

  • Polarity: The functional groups present impact the overall polarity of the compound, which, in turn, affects solubility in various solvents.
  • Solvent Compatibility: This compound may show better solubility in organic solvents such as ethanol or dimethyl sulfoxide (DMSO) compared to water due to its structure.
  • Temperature Effects: Solubility can be temperature-dependent; often, increasing temperature results in a higher solubility for organic compounds.
  • Hydrogen Bonding: The ability of N-methyl-N-prop-2-ynyl-2,3,4,5-tetrahydro-1-benzothiepin-5-amine to form hydrogen bonds can facilitate its dissolution in polar solvents.
  • Potential Outlook: In practical scenarios, conducting solubility tests in various solvents can provide valuable insights for chemical handling and application.

In summary, while the specific solubility of N-methyl-N-prop-2-ynyl-2,3,4,5-tetrahydro-1-benzothiepin-5-amine may not be universally quantified, exploring the factors influencing its solubility can lead to a better understanding of its behavior in different environments.

Interesting facts

Interesting Facts about N-methyl-N-prop-2-ynyl-2,3,4,5-tetrahydro-1-benzothiepin-5-amine

N-methyl-N-prop-2-ynyl-2,3,4,5-tetrahydro-1-benzothiepin-5-amine is an intriguing compound that finds its relevance in both medicinal chemistry and the study of organic synthesis. Here are some fascinating points about this compound:

  • Pharmacological Potential: This compound is of particular interest due to its potential medicinal applications. It is believed to possess properties that could influence neurological functions, making it a candidate for research into treatments for disorders such as depression or anxiety.
  • Unique Structure: The structure of this compound, featuring the bicyclic benzothiepin system, plays a crucial role in its biological activity. The tetrahydro configuration, along with the presence of the nitrogen and sulfur atoms, contributes to its chemical reactivity and potential pharmacological effects.
  • Asymmetric Synthesis: The synthesis of this compound can involve asymmetric methodologies, which are essential in creating compounds that mirror biological systems. The construction of such complex molecules allows chemists to explore multiple reaction pathways and optimize yields.
  • Research Applications: Chemists and pharmacologists often use this compound as a model for exploring the interaction between amine groups and various receptors in the brain. Its behavior in different environments aids in understanding drug-receptor interaction dynamics.
  • Synthesis Challenges: The synthesis of N-methyl-N-prop-2-ynyl-2,3,4,5-tetrahydro-1-benzothiepin-5-amine can present challenges due to its steric and electronic properties. A variety of reaction conditions must be optimized to successfully create this compound, making it a valuable subject for organic chemists.
  • Potential Side Effects: As with many biologically active compounds, studying the side effect profile of this compound is vital. Understanding its interaction with different systems can help in defining safer therapeutic windows.

This compound exemplifies the intersection of synthetic organic chemistry and pharmacology, making it a valuable subject for both research and practical applications. Its structural complexity and potential utility in therapeutic settings demonstrate how a single compound can impact various fields of science.