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N-Methylacetamide

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Identification
Molecular formula
C3H7NO
CAS number
79-16-3
IUPAC name
N-methylacetamide
State
State

At room temperature, N-methylacetamide is a liquid. It remains in a liquid state over a wide range of temperatures due to its relatively low melting point and high boiling point.

Melting point (Celsius)
3.00
Melting point (Kelvin)
276.15
Boiling point (Celsius)
204.00
Boiling point (Kelvin)
477.15
General information
Molecular weight
73.10g/mol
Molar mass
73.0950g/mol
Density
0.9358g/cm3
Appearence

N-Methylacetamide is a colorless liquid. It is highly polar and hygroscopic, which means it can readily absorb moisture from the air. The liquid form is clear and it has a characteristic amide odor.

Comment on solubility

Solubility of N-methylacetamide

N-methylacetamide, with the chemical formula C3H7NO, is known for its interesting solubility characteristics. This compound is a polar amide, which significantly influences its solubility in various solvents. Here are some key points regarding the solubility of N-methylacetamide:

  • Water Solubility: N-methylacetamide is soluble in water. The polar nature of the molecule allows it to interact favorably with water molecules, making it a versatile solvent in biochemical applications.
  • Organic Solvents: It is also soluble in a variety of organic solvents such as ethanol, methanol, and acetone, contributing to its usefulness in organic synthesis.
  • Hydrophilic Properties: The presence of both a carbonyl group and an amino group makes N-methylacetamide quite effective in forming hydrogen bonds, enhancing its solubility.

In summary, the solubility of N-methylacetamide is characterized by its ability to dissolve in both polar and some non-polar solvents, making it a valuable compound in multiple chemical contexts. Such properties allow for practical applications in areas ranging from pharmaceuticals to industrial processes.

Interesting facts

Interesting Facts About N-methylacetamide

N-methylacetamide is an intriguing compound that offers a combination of unique properties and applications in various fields of chemistry and industry. Here are some fascinating insights:

  • Solvent Properties: N-methylacetamide is primarily valued as a solvent. Its polar nature makes it particularly effective in dissolving a variety of organic compounds and polymers, making it a crucial component in many chemical processes.
  • Biochemical Importance: This compound is not only important in industrial applications but also in biological research. It is utilized as a reagent in the synthesis of pharmaceutical compounds, influencing drug development and discovery.
  • Versatility in Reactions: N-methylacetamide participates in diverse chemical reactions such as acylation and alkylation. Its ability to act as both a nucleophile and electrophile enhances its utility in organic synthesis.
  • Environmental Considerations: As a solvent, it is often scrutinized for its environmental impact. Understanding the ecological effects of N-methylacetamide helps in promoting safer and more sustainable chemical manufacturing practices.
  • Structural Similarity: Chemically, N-methylacetamide shares structural characteristics with both amides and methyl compounds, making it a subject of interest when studying reactivity and stability in organic chemistry.

In conclusion, N-methylacetamide stands out not just for its practical applications but also for its role in advancing our understanding of chemical behavior. As quoted in various scientific studies, the compound’s contribution to organic synthesis and its potential environmental effects is a reminder of the dual nature of many chemicals: useful yet requiring responsible management.

Synonyms
N-METHYLACETAMIDE
79-16-3
Methylacetamide
Acetamide, N-methyl-
Monomethylacetamide
N-Acetyl-N-methylamine
Acetylmethylamine
Methyl acetamide
N-Methyl acetamide
Acetamide, methyl-
N-Monomethylacetamide
N-Methyl-acetamide
HSDB 94
Acetic acid, amide, N-methyl
DTXSID0047167
NSC 747
X 44
EINECS 201-182-6
UNII-V0T777481M
CHEBI:87321
AI3-18019
NSC-747
CH3CONHCH3
DTXCID8027167
N-METHYLACETAMIDE [HSDB]
EC 201-182-6
V0T777481M
NMethyl acetamide
Acetamide, methyl
Acetamide, Nmethyl
NMonomethylacetamide
MFCD00008683
methane, methylcarbamoyl-
Acetic acid, amide, Nmethyl
N-Methylacetamide, >=99%
Pesticide Code: 067301
WLN: 1VM1
CHEMBL11544
NSC747
METHYL ACETAMIDE [INCI]
Tox21_300192
AKOS008933407
CAS-79-16-3
NCGC00247922-01
NCGC00254149-01
NML
DB-002828
CS-0031873
M0133
NS00002688
EN300-54106
Q12871952
Z32016274
n-methylacetamide;acetamide, n-methyl-;nmethylacetamide;n-methylacetamide acetamide, n-methyl- nmethylacetamide