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N-Methylformamide

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Identification
Molecular formula
C2H5NO
CAS number
123-39-7
IUPAC name
N-methylformamide
State
State

N-Methylformamide exists as a liquid at room temperature.

Melting point (Celsius)
-3.00
Melting point (Kelvin)
270.00
Boiling point (Celsius)
199.50
Boiling point (Kelvin)
472.70
General information
Molecular weight
59.07g/mol
Molar mass
59.0670g/mol
Density
1.0070g/cm3
Appearence

N-Methylformamide is a colorless to pale yellow liquid with a faint amine-like odor. It is a clear liquid at room temperature.

Comment on solubility

Solubility of N-methylformamide

N-methylformamide (NMF), with the chemical formula C2H5NO, is a polar solvent that exhibits remarkable solubility characteristics. Understanding its solubility is crucial for various applications in chemical synthesis and industrial processes. Here are some key points to consider:

  • Water Solubility: N-methylformamide is highly soluble in water, which allows it to interact effectively with other polar compounds.
  • Organic Solvents: It also demonstrates good solubility in many organic solvents such as alcohols, ethers, and hydrocarbons, making it versatile for different chemical reactions.
  • Temperature Dependence: The solubility of NMF can vary with temperature, generally increasing at higher temperatures.
  • Viscosity Impact: Its viscosity can affect the solubility of other compounds, especially in concentrated solutions, where interactions become more significant.

It's essential to note that the polar nature of N-methylformamide is primarily responsible for its superior solubility properties. As quoted in scientific literature, "the ability to mix with both polar and non-polar solvents enhances its utility in various chemical processes." Thus, N-methylformamide is not only an effective solvent but also a valuable compound in the realm of chemical research and development.

Interesting facts

Interesting Facts about N-methylformamide

N-methylformamide, often referred to as NMF, is an intriguing compound in the realm of organic chemistry. Here are some captivating details that highlight its significance and versatility:

  • Solvent Powerhouse: NMF is renowned for its ability to dissolve a wide variety of polar and non-polar compounds. This makes it a valuable solvent in numerous chemical processes.
  • Industrial Use: NMF is frequently utilized as an intermediate in the synthesis of pharmaceuticals, pesticides, and various organic chemicals, showcasing its importance in industry.
  • Biological Relevance: The structure of N-methylformamide allows it to participate in biochemical reactions, making it a subject of interest in medicinal chemistry and biochemistry.
  • H-Bonding: NMF can engage in hydrogen bonding due to its amide functional group, influencing solubility and reactivity with other substances.
  • Environmental Impact: As with many solvents, understanding the environmental effects and proper disposal methods of NMF is crucial for sustainable chemistry practices.

According to chemists, "The ability of N-methylformamide to act as a solvent and a reactant contributes to its creative applications in research and manufacturing." This emphasizes NMF's dual role in enhancing chemical reactions while being a versatile medium.

As a member of the amide family, NMF’s unique properties make it a fascinating subject of study, shedding light on the broader characteristics of organic compounds. Its presence in various chemical processes highlights the interconnectedness of chemistry and the potential for innovative applications.

Synonyms
N-METHYLFORMAMIDE
123-39-7
Methylformamide
Formamide, N-methyl-
Monomethylformamide
n-methyl-Formamide
N-Monomethylformamide
NSC 3051
EK 7011
Formic acid amide, N-methyl-
X 188
formylmethylamine
CHEBI:7438
XPE4G7Y986
DTXSID0025608
NSC3051
NSC-3051
Formamide, N-methyl
RefChem:830717
DTXCID905608
204-624-6
N-Formylmethylamine
HCONHCH3
Formamide, methyl-
methylimidoformic acid
N-Methyl-formimidic acid
MFCD00003280
NMF
(E)-methylimidoformic acid
(Z)-methylimidoformic acid
N-METHYL-FORMIC ACID-AMIDE
N-Methylformamide, 99%
methanimidic acid, methyl-
N-Methyl formamide
HSDB 100
EINECS 204-624-6
BRN 1098352
UNII-XPE4G7Y986
AI3-26076
n-methylcarboxamide
N-methylmethanamide
Methylformamide; Monomethylformamide; N-Methylformimidic Acid; N-Monomethylformamide; NSC 3051
methyl-Methanimidic acid
n-methyl Formic acid amide
WLN: VHM1
EC 204-624-6
SCHEMBL1936
SCHEMBL5670
CHEMBL9240
Formamide, N-methyl- ( )
SCHEMBL78284
4-04-00-00170 (Beilstein Handbook Reference)
SCHEMBL151164
SCHEMBL380627
SCHEMBL574943
N-METHYLFORMAMIDE [MI]
SCHEMBL1387635
SCHEMBL6349880
SCHEMBL6360485
SCHEMBL9524737
N-METHYLFORMAMIDE [HSDB]
BBL027430
STL146549
AKOS000118787
SB85388
NCI60_002574
DB-046834
LQ3000000
F0059
NS00006200
EN300-19419
A805066
Q138742
BRD-K33445938-001-01-8
F0001-0365
Z104473766