Skip to main content

N-(o-tolyl)acetamide

ADVERTISEMENT
Identification
Molecular formula
C9H11NO
CAS number
614-80-2
IUPAC name
N-(o-tolyl)acetamide
State
State

N-(o-tolyl)acetamide is primarily found in a solid state at room temperature. The compound assumes a crystalline form and is stable under standard conditions.

Melting point (Celsius)
152.00
Melting point (Kelvin)
425.15
Boiling point (Celsius)
333.00
Boiling point (Kelvin)
606.15
General information
Molecular weight
149.19g/mol
Molar mass
149.1890g/mol
Density
1.1080g/cm3
Appearence

N-(o-tolyl)acetamide typically appears as a white to off-white crystalline solid. The compound is characterized by its ability to form regular, crystalline structures.

Comment on solubility

Solubility of N-(o-tolyl)acetamide

N-(o-tolyl)acetamide, with the chemical formula C9H11NO, exhibits interesting solubility characteristics that are essential for its applications in various chemical processes. In general, the solubility of an organic amide like N-(o-tolyl)acetamide can be influenced by several factors:

  • Polarity: The presence of the amide functional group contributes to its polar nature, enabling it to dissolve in polar solvents to a certain extent.
  • Hydrogen Bonding: The molecule can engage in hydrogen bonding, potentially increasing solubility in polar solvents such as water, although steric hindrance from the o-tolyl group may reduce this effect.
  • Solvent Compatibility: N-(o-tolyl)acetamide is more likely to be soluble in organic solvents like ethanol, methanol, and acetone, while its solubility in pure water may be limited.

In practical terms, it is often observed that:

  1. The compound displays moderate solubility in organic fluids.
  2. Temperature plays a crucial role; increased temperature often enhances solubility.
  3. The structure's steric factors may hinder complete dissolution in highly polar solvents.

In summary, while N-(o-tolyl)acetamide can dissolve in several mediums, the extent of its solubility is contingent upon the balance of polar and non-polar characteristics, with particular emphasis on the influence of solvent choice and environmental conditions.

Interesting facts

Exploring N-(o-tolyl)acetamide

N-(o-tolyl)acetamide is a fascinating organic compound that has garnered attention in various fields of chemistry due to its unique properties and potential applications. Here are some intriguing facts about this compound:

  • Structure and Isomerism: This compound features a distinctive structure that includes an o-tolyl group, which is derived from toluene. The positioning of the methyl group on the aromatic ring gives rise to interesting isomeric forms, laying the groundwork for a range of derivatives with diverse properties.
  • Biological Significance: N-(o-tolyl)acetamide is known for its bioactivity. Research has indicated that compounds of this class can exhibit biological activities such as anti-inflammatory, antimicrobial, and analgesic effects, making them of interest in pharmacological studies.
  • Synthesis: The synthesis of N-(o-tolyl)acetamide can be accomplished through various methods, often involving acylation reactions. These reactions are not only valuable for understanding compound formation but also for exploring new synthetic pathways in organic chemistry.
  • Applications in Industry: Beyond its scholarly interest, N-(o-tolyl)acetamide finds its use in industrial applications, particularly as a reagent in organic synthesis. Its ability to participate in certain chemical reactions makes it useful for producing more complex structures.
  • Research Potential: Ongoing research into N-(o-tolyl)acetamide and other derivatives is vital. The exploration of their properties could lead to new findings in materials science, medicinal chemistry, and the development of novel therapeutic agents.

In summary, N-(o-tolyl)acetamide is not just another organic compound; it is a bridge between basic research and practical applications. As chemists delve deeper into its capabilities, who knows what exciting discoveries await?

Synonyms
120-66-1
o-Acetotoluidide
N-(2-Methylphenyl)acetamide
N-(o-Tolyl)acetamide
2'-Methylacetanilide
o-Acetotoluide
Acetyl-o-toluidine
o-Methylacetanilide
Acetamide, N-(2-methylphenyl)-
N-ACETYL-O-TOLUIDINE
N-o-Tolylacetamide
N-Acetyl-2-toluidine
Acet-o-toluidide
N-Acetyl-o-toludine
2`-Methylacetanilide
o-Acetotoluidine
N-Acetoxy-2-toluidine
NSC 3365
CCRIS 1237
HSDB 4256
EINECS 204-414-4
DTXSID1024413
AI3-03946
NSC-3365
MFCD00014961
425I3L2A81
O-ACETOTOLUIDE [MI]
DTXCID704413
N-ACETYL-O-TOLUIDINE [HSDB]
Acetamide, N-(methylphenyl)-
oAcetotoluide
oAcetotoluidide
Acetylotoluidine
NoTolylacetamide
oMethylacetanilide
UNII-425I3L2A81
NAcetyl2toluidine
2Methylacetanilide
Acetyl-o-Toluidin
NAcetoxy2toluidine
N-acetyl 2-toluidine
N-(o-tolyl)-acetamide
O-ACETYLTOLUIDIDE
O-ACETAMIDOTOLUENE
N(2Methylphenyl)acetamide
N-ACETYL-O-TOLUIDIDE
Acetamide, N(2methylphenyl)
SCHEMBL96123
WLN: 1VMR B1
MLS002415753
N-(2-Methyl-phenyl)acetamide
N-(2-Methylphenyl)acetamide #
CHEMBL1568309
SCHEMBL10517748
BPEXTIMJLDWDTL-UHFFFAOYSA-
NSC3365
CHEBI:189137
N-(O-METHYLPHENYL)ACETAMIDE
Tox21_200288
STK073383
N-(2-METHYLPHENYL)-ACETAMIDE
AKOS000492802
PS-5222
NCGC00091880-01
NCGC00091880-02
NCGC00257842-01
CAS-120-66-1
SMR001370914
SY061619
DB-061764
A0063
CS-0152950
NS00014370
EN300-78573
10.14272/BPEXTIMJLDWDTL-UHFFFAOYSA-N
A51039
doi:10.14272/BPEXTIMJLDWDTL-UHFFFAOYSA-N
Q27258494
InChI=1/C9H11NO/c1-7-5-3-4-6-9(7)10-8(2)11/h3-6H,1-2H3,(H,10,11)