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N-(o-tolyl)formamide

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Identification
Molecular formula
C8H9NO
CAS number
1793-23-9
IUPAC name
N-(o-tolyl)formamide
State
State

At room temperature, N-(o-tolyl)formamide is in a solid state. It is usually handled as a crystalline or powdered form.

Melting point (Celsius)
45.00
Melting point (Kelvin)
318.15
Boiling point (Celsius)
313.00
Boiling point (Kelvin)
586.15
General information
Molecular weight
135.17g/mol
Molar mass
135.1650g/mol
Density
1.0488g/cm3
Appearence

N-(o-tolyl)formamide is typically a colorless to pale yellow solid. It might appear as crystalline in nature under standard conditions.

Comment on solubility

Solubility of N-(o-tolyl)formamide

N-(o-tolyl)formamide, with the chemical formula C9H11N1O1, exhibits unique solubility characteristics that are important in various applications. Understanding its solubility can help predict its behavior in different environments. Here’s a closer look:

  • Solvent Compatibility: N-(o-tolyl)formamide is generally soluble in polar organic solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO).
  • Water Solubility: The solubility of N-(o-tolyl)formamide in water is limited. Although it may dissolve to some extent due to the presence of the formamide group, it does not exhibit high solubility.
  • Temperature Effects: Its solubility can vary with temperature, typically increasing at higher temperatures, which is common for many organic compounds.

In summary, while N-(o-tolyl)formamide is soluble in several organic solvents, its limited solubility in water highlights the importance of considering solvent choice in chemical reactions and applications. As with many compounds, the context of use greatly influences its solubility, making this a crucial factor in the planning of experiments.

Interesting facts

Interesting Facts about N-(o-tolyl)formamide

N-(o-tolyl)formamide is an intriguing organic compound that belongs to the class of amides. It is formed from the reaction of o-toluidine with formic acid and has garnered attention for several reasons:

  • Chemical Structure: The compound features a unique combination of a tolyl group—derived from toluene—and a formamide functional group. This structure allows it to participate in various chemical reactions, making it a versatile building block in organic synthesis.
  • Applications in Research: N-(o-tolyl)formamide is often utilized in the field of medicinal chemistry. Researchers explore its potential therapeutic effects, and it serves as a precursor in the synthesis of other biologically active compounds.
  • Reactivity: Due to the presence of both amine and carbonyl functionalities, N-(o-tolyl)formamide can participate in a range of nucleophilic and electrophilic reactions. This property is vital for constructing complex organic molecules in laboratory settings.
  • Polarity and Solvation: The polar nature of N-(o-tolyl)formamide often leads to interesting interactions with solvents and other compounds, which can facilitate or impede chemical reactions. This reactivity makes it a compound of interest in solvent effects studies.

As noted by chemists, "The beauty of amides lies not only in their structure but also in their reactivity, bridging multiple realms of organic chemistry." The utilization of N-(o-tolyl)formamide in synthetic strategies reflects its significance in expanding the toolbox of organic chemists.

In conclusion, N-(o-tolyl)formamide exemplifies the diverse functionality of amides and their relevance in modern chemical research.

Synonyms
94-69-9
2'-Methylformanilide
2-Methylformanilide
N-(2-METHYLPHENYL)FORMAMIDE
Formamide, N-(2-methylphenyl)-
N-o-Tolylformamide
o-Formotoluidide
o-Tolylformamide
o-Methylformanilide
N-Formyl-2-methylaniline
2-Methylphenylformamide
o-Methyl-N-formylaniline
N-Formyl-o-toluidine
AI3-01417
EINECS 202-355-9
NSC 406128
DTXSID6059108
N-(2-Tolyl)formamide
Formyl-o-toluidin
2-formylaminotoluene
N-o-tolyl-formamide
MFCD00014122
2 -formylaminotoluene
2-formylamino-toluene
NCIOpen2_003729
N-(2-methylphenyl)methanamide
SCHEMBL225741
SCHEMBL9800974
N-(2-Tolyl)formamide, 97%
DTXCID7048906
NSC62002
NSC-62002
NSC406128
AKOS004909858
NSC-406128
AS-54916
DB-057523
CS-0038689
M1431
NS00040412
W11048
A845044
AB-131/41338123
202-355-9