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N-(p-tolyl)aziridine-1-carboxamide

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Identification
Molecular formula
C10H12N2O
CAS number
75689-00-8
IUPAC name
N-(p-tolyl)aziridine-1-carboxamide
State
State

At room temperature, N-(p-tolyl)aziridine-1-carboxamide is a solid.

Melting point (Celsius)
92.00
Melting point (Kelvin)
365.15
Boiling point (Celsius)
312.30
Boiling point (Kelvin)
585.45
General information
Molecular weight
176.22g/mol
Molar mass
176.2350g/mol
Density
1.1430g/cm3
Appearence

N-(p-tolyl)aziridine-1-carboxamide is a crystalline solid. It is typically white to off-white in color.

Comment on solubility

Solubility of N-(p-tolyl)aziridine-1-carboxamide

The solubility of N-(p-tolyl)aziridine-1-carboxamide can vary significantly depending on the solvent used. In general, this compound tends to exhibit the following characteristics:

  • Polar Solvents: N-(p-tolyl)aziridine-1-carboxamide is likely to be more soluble in polar solvents such as water, methanol, or ethanol due to the presence of the carboxamide functional group, which can form hydrogen bonds.
  • Non-Polar Solvents: The compound may show limited solubility in non-polar solvents like hexane or chloroform because of its polar nature.
  • Temperature Dependence: Its solubility may also be temperature-dependent; generally, higher temperatures can increase solubility in many solvents.

It is essential to note that solubility can be affected by various factors, including:

  1. Concentration of Solvent: Higher concentrations of solute may result in decreased solubility.
  2. pH of the Solution: Changes in pH can impact the ionization state of the carboxamide group.
  3. Presence of Other Solutes: The solubility may further be altered by interactions with other dissolved substances.

In summary, while N-(p-tolyl)aziridine-1-carboxamide exhibits favorable solubility in polar solvents, careful consideration of environmental conditions and solvent choice is vital for optimal dissolution.

Interesting facts

Interesting Facts about N-(p-tolyl)aziridine-1-carboxamide

N-(p-tolyl)aziridine-1-carboxamide is a fascinating compound with unique structural and chemical properties. Here are some engaging facts that highlight its importance:

  • Structural Characteristics: The compound features an aziridine ring, which is a three-membered cyclic amine, known for its strain and reactivity. This property is crucial for various chemical reactions, making aziridines a significant class of compounds in organic chemistry.
  • Reactivity and Applications: Aziridines, including N-(p-tolyl)aziridine-1-carboxamide, are intermediates in organic synthesis. They can undergo ring-opening reactions, leading to the formation of other functional groups and compounds. This characteristic lends aziridines to applications in medicinal chemistry, particularly in the development of pharmaceuticals.
  • Bioactivity: Compounds containing aziridine moieties have been studied for their biological activity. N-(p-tolyl)aziridine-1-carboxamide may possess interesting pharmacological properties, which could be explored for potential therapeutic uses. Research in this area often uncovers “hit” compounds that can be further developed into drug candidates.
  • Versatile Chemistry: The presence of a carboxamide functional group in the structure enhances the compound's versatility, allowing for various possible modifications. This functionality may contribute to solubility and interactions with biological targets, which are key considerations in drug design.
  • Dynamic Research Interest: Compounds like N-(p-tolyl)aziridine-1-carboxamide are subjects of ongoing research. Scientists often investigate new methods for synthesis and explore novel reactions to create even more complex structures, reflecting the inherent dynamism in the field of organic chemistry.

In summary, N-(p-tolyl)aziridine-1-carboxamide not only presents a compelling structure with a variety of chemical implications but also serves as a potential building block in pharmaceutical development. Its significance in chemistry and potential biological activity make it an intriguing subject for further study.

Synonyms
p-Tolyl-N-carbamoylaziridine
829-65-2
1-AZIRIDINECARBOXAMIDE, N-(p-TOLYL)-
BRN 1343670
1-Aziridinecarboxy-p-toluidide
AI3-50686
DTXSID30232074
DTXCID30154565
yzlzqbpztcofad-uhfffaoysa-n
1-Aziridinecarboxamide, N-(4-methylphenyl)-
N-(p-Tolyl)-1-aziridinecarboxamide
N-(4-methylphenyl)aziridine-1-carboxamide
N-(4-Methylphenyl)-1-aziridinecarboxamide #