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N-(p-tolylmethyl)acetamide

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Identification
Molecular formula
C10H13NO
CAS number
3608-07-1
IUPAC name
N-(p-tolylmethyl)acetamide
State
State
At room temperature, it is a solid.
Melting point (Celsius)
78.00
Melting point (Kelvin)
351.15
Boiling point (Celsius)
305.60
Boiling point (Kelvin)
578.80
General information
Molecular weight
163.22g/mol
Molar mass
163.2130g/mol
Density
1.1037g/cm3
Appearence

At room temperature, N-(p-tolylmethyl)acetamide appears as a crystalline solid. It typically forms colorless to light yellow crystals, depending on the purity and presence of any impurities in the sample.

Comment on solubility

Solubility of N-(p-tolylmethyl)acetamide

N-(p-tolylmethyl)acetamide, with the chemical formula C11H15NO, exhibits unique solubility characteristics that are noteworthy for various applications. This compound is generally described as being soluble in polar aprotic solvents due to the presence of its amide functional group.

Key Points on Solubility:

  • Polar Solvents: It dissolves effectively in polar solvents such as dimethyl sulfoxide (DMSO) and acetone.
  • Non-Polar Solvents: N-(p-tolylmethyl)acetamide may have limited solubility in non-polar solvents, influenced by its molecular structure.
  • Temperature Impact: Solubility can significantly increase with temperature, as the kinetic energy facilitates greater molecular interaction.
  • Amide Group Influence: The presence of the amide group generally enhances hydrogen bonding capabilities, leading to increased solubility in water compared to non-polar compounds.

As emphasized by solubility principles, "like dissolves like." Thus, understanding the interactions at play in N-(p-tolylmethyl)acetamide's structure offers insights into its solubility behavior. The compound's characteristics highlight its versatility for various chemical processes and formulations.

Interesting facts

Interesting Facts about N-(p-tolylmethyl)acetamide

N-(p-tolylmethyl)acetamide is a compound that epitomizes the intriguing world of organic chemistry, particularly in the realm of amides. This compound showcases the interaction of aromatic and aliphatic features, making it a focus of various studies.

Key Characteristics

  • Amide Nature: As an amide, it is derived from acetic acid and demonstrates typical amide reactivity. Amides generally show a range of chemical behavior that makes them important in both organic synthesis and biochemical processes.
  • Substituent Influence: The presence of the p-tolyl group significantly alters the compound's properties, enhancing its stability and influencing its reactivity. Such substituents can also modulate the compound's interaction with biological molecules.
  • Applications: N-(p-tolylmethyl)acetamide is often studied for its potential in pharmaceuticals. Compounds similar to this amide are known to exhibit noteworthy biological activities, including anti-inflammatory and analgesic properties.

Chemical Behavior

The acetamide functional group makes this compound particularly useful in various chemical reactions:

  1. Formation of Derivatives: It can serve as a starting material for synthesizing other biologically active compounds.
  2. Nucleophilic Reactions: The amide bond is susceptible to nucleophilic attack, which is a key feature in synthetic organic chemistry.

In conclusion, N-(p-tolylmethyl)acetamide is not just an ordinary compound; it represents the subtle interplay of molecular structure and function. The study of such compounds unveils the complexity of chemical interactions, and their implications in various fields such as medicinal chemistry and materials science cannot be overlooked.

Synonyms
25079-96-3
N-[(4-methylphenyl)methyl]acetamide
N-((4-METHYLPHENYL)METHYL)ACETAMIDE
DTXSID20179767
RefChem:359678
DTXCID80102258
N-(4-methylbenzyl)acetamide
N-(p-methylbenzyl)acetamide
SCHEMBL171709
N-(4-methyl-benzyl)-acetamide
SCHEMBL3751727
VSKJCTSEACBXRC-UHFFFAOYSA-N
AKOS003863288
GS-0457
Acetamide, N-[(4-methylphenyl)methyl]-