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Tacrine

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Identification
Molecular formula
C13H14N2
CAS number
321-64-2
IUPAC name
N-pentyl-1,2,3,4-tetrahydroacridin-9-amine
State
State
Tacrine is a solid at room temperature, usually available as a crystalline powder.
Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
402.00
Boiling point (Kelvin)
675.15
General information
Molecular weight
198.27g/mol
Molar mass
198.2800g/mol
Density
1.0990g/cm3
Appearence

Tacrine appears as a white to off-white crystalline powder. It is typically available in its hydrochloride salt form, which is soluble in water and has a slight amine-like odor.

Comment on solubility

Solubility of N-pentyl-1,2,3,4-tetrahydroacridin-9-amine

N-pentyl-1,2,3,4-tetrahydroacridin-9-amine, a compound that blends structural complexity with interesting solubility characteristics, presents a nuanced behavior in various solvents.

The solubility of this compound can be largely influenced by the following factors:

  • Polarity of Solvent: As a generally non-polar molecule, N-pentyl-1,2,3,4-tetrahydroacridin-9-amine tends to dissolve better in non-polar or low-polarity solvents like hexane or chloroform.
  • Temperature: Solubility can increase with temperature, making it more feasible to dissolve in solvents when heated.
  • Functional Groups: The presence of amine groups may allow for limited solubility in polar solvents like water, but this is often minimal due to steric hindrance.

In summary, while it may not be highly soluble in water, the compound can certainly find sufficient solubility in organic solvents, which makes it versatile for various applications. As one might say, "Choose your solvent wisely," as this can greatly affect the outcomes in practical scenarios.

Interesting facts

Interesting Facts about N-pentyl-1,2,3,4-tetrahydroacridin-9-amine

N-pentyl-1,2,3,4-tetrahydroacridin-9-amine, often referred to simply as a derivative of tetrahydroacridine, has garnered interest in various fields, particularly in medicinal chemistry and neuropharmacology. Here are some compelling aspects of this compound:

  • Structure and Function: The unique structure, featuring a tetrahydroacridine core, allows for potential interactions within biological systems, especially in the context of neurotransmitter systems.
  • Pharmaceutical Applications: Compounds like N-pentyl-1,2,3,4-tetrahydroacridin-9-amine are studied for their capabilities to act as cognitive enhancers, providing possibilities in the treatment of neurodegenerative diseases such as Alzheimer’s.
  • Mechanism of Action: By influencing acetylcholine receptors, this compound can modulate neurotransmission, which is critical for memory and learning processes.
  • Synthesis and Modification: The synthetic pathways for creating this compound often involve various chemical reactions, including alkylation and cyclization, allowing for structural modifications that can enhance or alter its biological activity. As a result, it serves as a versatile point for further derivation.

Researchers are continually exploring the potential therapeutic benefits this compound might offer. It's fascinating to note that the broad range of possible modifications leads to derivatives that could significantly impact how we understand and treat cognitive disorders.

Overall, N-pentyl-1,2,3,4-tetrahydroacridin-9-amine serves as not just an interesting molecule, but a promising candidate in the world of pharmacological research, highlighting the intricate connections between chemistry and biology!

Synonyms
316-87-0
BRN 0408904
ACRIDINE, 1,2,3,4-TETRAHYDRO-9-(PENTYLAMINO)-
1,2,3,4-Tetrahydro-9-(pentylamino)acridine
N-pentyl-1,2,3,4-tetrahydroacridin-9-amine
9-Acridinamine, 1,2,3,4-tetrahydro-N-pentyl-
DTXSID30185490
5-22-10-00481 (Beilstein Handbook Reference)
SCHEMBL8525172
DTXCID40107981