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2-amino-2-oxazoline

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Identification
Molecular formula
C8H10N2O
CAS number
759-55-9
IUPAC name
N-phenyl-4,5-dihydrooxazol-2-amine
State
State

2-amino-2-oxazoline is typically a liquid at room temperature, though it can solidify upon cooling.

Melting point (Celsius)
17.00
Melting point (Kelvin)
290.15
Boiling point (Celsius)
220.00
Boiling point (Kelvin)
493.15
General information
Molecular weight
110.13g/mol
Molar mass
110.1290g/mol
Density
1.1300g/cm3
Appearence

2-amino-2-oxazoline is typically a colorless liquid, but it may also appear as a pale yellowish liquid under certain conditions. Its appearance is clear to slightly hazy, and upon prolonged standing, it may develop a slight yellow tint due to aging or slight impurities.

Comment on solubility

Solubility of N-phenyl-4,5-dihydrooxazol-2-amine

N-phenyl-4,5-dihydrooxazol-2-amine exhibits intriguing solubility characteristics that may influence its applications in various chemical processes. Understanding its solubility is crucial for both practical use and theoretical exploration.

Key Solubility Points:

  • Polar versus Nonpolar Solvents: This compound is likely to be more soluble in polar organic solvents due to the presence of the amine group, which can engage in hydrogen bonding, enhancing solubility.
  • Temperature Effects: As with many organic compounds, solubility can improve with an increase in temperature; thus, heating the solvent may facilitate dissolution.
  • Concentration Factors: High concentrations may lead to precipitation issues, where excess N-phenyl-4,5-dihydrooxazol-2-amine may not remain dissolved, leading to saturation points.
  • Influence of pH: The solubility of amine-containing compounds can be highly affected by pH balances; altering pH may increase or decrease solubility due to protonation/deprotonation reactions.

In summary, the solubility of N-phenyl-4,5-dihydrooxazol-2-amine is highly dependent on the solvent characteristics, temperature, concentration, and pH level. Proper consideration of these factors is essential for optimizing its functionality in various chemical applications.

Interesting facts

Interesting Facts About N-phenyl-4,5-dihydrooxazol-2-amine

N-phenyl-4,5-dihydrooxazol-2-amine is a fascinating compound in the field of organic chemistry, particularly due to its unique structural features and potential applications. Here are some noteworthy aspects:

  • Structural Significance: This compound contains a dihydrooxazole ring, a five-membered heterocyclic structure that contributes to its reactivity and properties. The presence of both nitrogen and oxygen atoms within the ring makes it an interesting candidate for further chemical modifications.
  • Pharmaceutical Potential: Compounds featuring oxazole rings and amine functionalities have garnered attention for their biological activities. Some derivatives have been investigated as potential *antimicrobial* or *antifungal agents*, showcasing the importance of this scaffold in drug development.
  • Versatile Synthesis: The synthesis of N-phenyl-4,5-dihydrooxazol-2-amine can be achieved through various routes, often involving the condensation of amines and aldehydes. This versatility allows chemists to explore numerous synthetic methodologies to obtain this compound, which further enhances its utility in research.
  • Research Interest: The compound also serves as a starting material for the synthesis of novel derivatives, leading to ongoing research aimed at tapping into unexplored biological activities. The functionalization of the oxazole ring presents opportunities for developing new classes of compounds with tailored properties.

In summary, N-phenyl-4,5-dihydrooxazol-2-amine is more than just a chemical entity; it represents a connection between synthetic chemistry and its applications in the pharmaceutical industry.

Synonyms
2-Anilino-2-oxazoline
ANILINE, N-(2-OXAZOLIN-2-YL)-
N-(2-Oxazolinyl)aniline
27151-01-5
2-Phenyliminooxazolidine
TYG70FN2WE
Oxazole, 4,5-dihydro-2-phenylamino-
NSC 160004
UNII-TYG70FN2WE
NSC-160004
DTXSID30181619
2-OXAZOLINE, 2-ANILINO-
2-N-PHENYLAMINO-2-OXAZOLINE
OXAZOLIDINE, 2-(PHENYLIMINO)-
2-Oxazolamine, 4,5-dihydro-N-phenyl-
2-(PHENYLIMINO)-1,3-OXAZOLIDINE
4,5-DIHYDRO-N-PHENYL-2-OXAZOLAMINE
RefChem:197928
DTXCID20104110
oxazolinylaniline
NSC160004
CHEMBL498826
SCHEMBL1852744
SCHEMBL1852745
SCHEMBL7171231
SCHEMBL7171234
SCHEMBL17728316
AKOS006278433
DS-004315
2-OXAZOLAMINE,4,5-DIHYDRO-N-PHENYL-