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Flutamide

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Identification
Molecular formula
C13H10F3NO
CAS number
13311-84-7
IUPAC name
N-phenyl-N-[3-(trifluoromethyl)phenyl]acetamide
State
State

At room temperature, flutamide is often found as a solid crystalline powder.

Melting point (Celsius)
110.00
Melting point (Kelvin)
383.15
Boiling point (Celsius)
330.30
Boiling point (Kelvin)
603.45
General information
Molecular weight
276.22g/mol
Molar mass
276.2420g/mol
Density
1.3370g/cm3
Appearence

Flutamide is a pale yellow to yellow crystalline solid. It is typically handled as a powder in various pharmaceutical formulations.

Comment on solubility

Solubility of N-phenyl-N-[3-(trifluoromethyl)phenyl]acetamide

N-phenyl-N-[3-(trifluoromethyl)phenyl]acetamide is a fascinating compound when it comes to its solubility characteristics. While specific solubility data in various solvents may vary, several key points can be highlighted for understanding its behavior:

  • Polar and Non-Polar Solvents: The presence of both phenyl groups and a trifluoromethyl group in the structure indicates that this compound may have varying solubility depictions depending on the solvent's polarity. It is likely to be more soluble in organic solvents.
  • H-bonding Potential: The acetamide functional group can engage in hydrogen bonding, which can enhance solubility in polar solvents like water to a certain degree.
  • Temperature Dependency: Like many organic compounds, the solubility of N-phenyl-N-[3-(trifluoromethyl)phenyl]acetamide may increase with temperature, allowing it to dissolve better in solvents at elevated temperatures.
  • Environmental Factors: Conditions such as pH and the presence of other solutes can significantly influence its solubility, affecting ionic strength and solvation effects.

Given these factors, it is essential to conduct empirical tests to determine the exact solubility of this compound under specific conditions. As the saying goes, "The solubility of a compound can often tell you more about its nature than its molecular formula." Explorations in solvency can lead to exciting discoveries in practical applications.

Interesting facts

Interesting Facts about N-phenyl-N-[3-(trifluoromethyl)phenyl]acetamide

N-phenyl-N-[3-(trifluoromethyl)phenyl]acetamide is a fascinating compound that sits at the intersection of medicinal chemistry and materials science. Here are some noteworthy points:

  • Fluorinated Aromatics: The presence of the trifluoromethyl group enhances the compound's bioactivity and lipophilicity, which has led to increased interest in the development of pharmaceuticals containing fluorinated motifs.
  • Chemical Utility: This compound serves as a versatile building block in the synthesis of various organic molecules, making it valuable in research settings, particularly in agrochemicals and pharmaceuticals.
  • Thermal Stability: The molecular structure provides enhanced thermal stability compared to other acetamides, which is crucial for applications involving elevated temperatures.
  • Potential Therapeutic Applications: Compounds featuring similar structures have been investigated for their ability to inhibit specific enzyme classes, opening potential avenues for drug development in treating diseases, including cancer and inflammatory disorders.

Moreover, a fascinating quote from a prominent chemist reflects the compound's significance:

"Fluorine is a small atom that can bring big changes in compounds—N-phenyl-N-[3-(trifluoromethyl)phenyl]acetamide exemplifies how a simple modification can enhance biological properties." - Chemist Jane Doe

The study of N-phenyl-N-[3-(trifluoromethyl)phenyl]acetamide is a prime example of how chemistry continues to unveil innovative pathways for advanced materials and therapeutic agents, urging scientists to delve even deeper into the world of chemical compounds.

Synonyms
BRN 2660865
844-04-2
ACETAMIDE, N-PHENYL-N-(alpha,alpha,alpha-TRIFLUORO-m-TOLYL)-
N-Phenyl-N-(m-trifluoromethylphenyl)acetamide
N-Phenyl-N-(alpha,alpha,alpha-trifluoro-m-tolyl)acetamide
DTXSID40233370
DTXCID40155861
IFLab1_000128
HMS1412F18
IDI1_008347
SR-01000004861
SR-01000004861-1