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Propacetamol

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Identification
Molecular formula
C11H15NO2
CAS number
66532-86-3
IUPAC name
N-phenyl-N-propyl-acetamide
State
State

At room temperature, propacetamol is typically in a solid state and is often encountered as a part of pharmaceutical manufacturing for intravenous administration.

Melting point (Celsius)
109.00
Melting point (Kelvin)
382.15
Boiling point (Celsius)
291.00
Boiling point (Kelvin)
564.15
General information
Molecular weight
193.27g/mol
Molar mass
193.2650g/mol
Density
0.8837g/cm3
Appearence

Propacetamol typically appears as a white solid. It is commonly supplied in crystalline powder form for ease of use in pharmaceutical formulations.

Comment on solubility

Solubility of N-phenyl-N-propyl-acetamide

N-phenyl-N-propyl-acetamide, a compound with interesting structural characteristics, exhibits unique solubility properties. Its solubility can be understood through several key factors:

  • Polarity: The presence of the acetylamide functional group contributes to partial polarity, which can promote solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds enhances its interaction with solvents, particularly in the presence of polar functional groups.
  • Solvent Compatibility: N-phenyl-N-propyl-acetamide tends to dissolve well in organic solvents like ethanol, acetone, and chloroform, while showing limited solubility in nonpolar solvents.

Despite these characteristics, it is essential to note the following:

  1. The solubility in water is considerably low due to the hydrophobic C6H5 group.
  2. As the temperature rises, the solubility generally increases, which is a common trait among many organic compounds.

In summary, while N-phenyl-N-propyl-acetamide has the potential for solubility in select polar and nonpolar solvents, its overall effectiveness in a given solution will depend on multiple factors, including temperature and the nature of the solvent used. As with many compounds, understanding these solubility traits is crucial for practical applications in various chemical processes.

Interesting facts

Interesting Facts about N-phenyl-N-propyl-acetamide

N-phenyl-N-propyl-acetamide is an intriguing compound that belongs to the class of amides. This compound combines a phenyl group with a propyl group, attached to an acetamide backbone, which makes it particularly noteworthy in various fields of chemistry.

Key Features

  • Versatile Structure: The presence of both aromatic (phenyl) and aliphatic (propyl) groups allows this compound to exhibit diverse chemical behaviors and reactivity. This versatility can be explored in many synthetic pathways.
  • Pharmaceutical Potential: Many phenyl and acetamide derivatives are known for their biological activity. N-phenyl-N-propyl-acetamide could potentially exhibit pharmacological properties worth investigating, opening avenues in medicinal chemistry.
  • Industrial Applications: Compounds containing phenyl and propyl groups are commonly used in the production of dyes, fragrances, and polymers. This compound's structure might make it suitable for similar industrial applications.

Chemical Insights

As a chemist or a student of chemistry, you might find the following points about N-phenyl-N-propyl-acetamide particularly fascinating:

  • Amide Bond Character: The amide functional group introduces unique properties such as stability and the ability to engage in hydrogen bonding, which can affect solubility and reactivity.
  • Isomerism: This compound can exist in different isomeric forms, which demonstrates how slight changes in structure can impact chemical behavior and properties significantly.
  • Functional Group Interactions: The coexistence of the acetamide and phenyl groups makes it a prime candidate for studying intermolecular interactions, particularly in biological systems.

In conclusion, N-phenyl-N-propyl-acetamide exemplifies the interplay of different chemical functionalities, suggesting rich possibilities for further research and application in the realms of synthesis, pharmaceuticals, and industrial uses. Exploring such compounds not only enhances our understanding of organic chemistry but also inspires innovative solutions to real-world challenges.

Synonyms
N-Propylacetanilide
N-Phenyl-N-propylacetamide
ACETANILIDE, N-PROPYL-
Acetamide, N-phenyl-N-propyl-
NSC 4700
O69TFQ5FM7
BRN 2937367
AI3-05524
NSC-4700
UNII-O69TFQ5FM7
DTXSID30179117
DTXCID60101608
Acetamide, N-phenyl-N-propyl-(9CI)
4-12-00-00379 (beilstein handbook reference)
2437-98-1
N-phenyl-N-propyl-acetamide
ACETYL-N-PROPYLANILINE
NSC4700
Acetamide, N-phenyl-N-propyl- (9CI)
aniline, N-acetyl-N-propyl-
WLN: 3NR&V1
SCHEMBL2069635
AKOS006278993