Skip to main content

N'-phenylacetohydrazide

ADVERTISEMENT
Identification
Molecular formula
C8H10N2O
CAS number
114-83-0
IUPAC name
N'-phenylacetohydrazide
State
State

Solid

At room temperature, N'-phenylacetohydrazide remains in a solid state, which is typical for crystalline compounds of its kind.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
326.00
Boiling point (Kelvin)
599.15
General information
Molecular weight
164.18g/mol
Molar mass
164.1940g/mol
Density
1.2210g/cm3
Appearence

N'-phenylacetohydrazide typically appears as a white crystalline powder. It is solid at room temperature and is generally stable under normal conditions.

Comment on solubility

Solubility of N'-phenylacetohydrazide

N'-phenylacetohydrazide, a compound with intriguing properties, shows varying degrees of solubility depending on the solvent used. Understanding its solubility behavior is essential for applications in chemical synthesis and formulation.

Key Solubility Characteristics:

  • Solvent Dependency: N'-phenylacetohydrazide tends to exhibit solubility in organic solvents such as ethanol and acetone.
  • Water Solubility: This compound has limited solubility in water due to its hydrophobic phenyl group, which inhibits complete dissolution.
  • Temperature Influence: Increasing the temperature generally enhances solubility, making it easier to dissolve in certain solvents.

In conclusion, while N'-phenylacetohydrazide is soluble in specific organic solvents, its water solubility remains low. This solubility profile must be considered when utilizing this compound in various chemical processes or formulations.

Interesting facts

Interesting Facts About N'-phenylacetohydrazide

N'-phenylacetohydrazide is an intriguing compound that is primarily known for its application in organic chemistry and pharmaceutical research. Here are some notable aspects of this compound:

  • Versatile Intermediate: N'-phenylacetohydrazide serves as an important intermediate in the synthesis of various pharmaceutical agents and agrochemicals. Its derivatives have been studied for antitumor and antimicrobial activities.
  • Hydrazone Formation: This compound is capable of undergoing hydrazone formation, a reaction where hydrazines react with carbonyl compounds. This reaction is pivotal in the synthesis of other valuable molecules.
  • Structural Insights: The structure features both hydrazine and acetamide functionalities, providing a unique versatility that researchers can exploit. The phenyl group enhances its stability and pKa, influencing its reactivity.
  • Applications: Beyond its use in drug synthesis, N'-phenylacetohydrazide finds application in dye chemistry due to its ability to form colored complexes with various metals.
  • Research Interest: The compound has garnered attention in recent studies focused on developing more effective therapeutic agents, especially in cancer treatment, where its derivatives show promise in promoting cytotoxic effects on cancer cells.

In conclusion, N'-phenylacetohydrazide offers a range of synthetic possibilities and therapeutic applications, making it a compound worth exploring further in both academic research and industrial settings. As the field of medicinal chemistry continues to evolve, compounds like N'-phenylacetohydrazide will be pivotal in unlocking new treatments and enhancing our understanding of chemical reactivity.

Synonyms
1-Acetyl-2-phenylhydrazine
114-83-0
N'-Phenylacetohydrazide
Acetylphenylhydrazine
Hydracetin
Acetic acid, 2-phenylhydrazide
Pyrodine
Pyrodin
N-Acetyl-N'-phenylhydrazine
N'-Phenylacethydrazide
Acetic acid phenylhydrazone
1-Phenyl-2-acetylhydrazine
beta-Acetylphenylhydrazine
N(1)-Acetylphenylhydrazine
2'-Phenylacetohydrazide
Fenylhydrazid kyseliny octove
.beta.-Acetylphenylhydrazine
NSC 2064
2-Phenylhydrazide acetic acid
CCRIS 4569
HSDB 7235
APH
EINECS 204-055-3
Fenylhydrazid kyseliny octove [Czech]
acetic acid 2-phenylhydrazide
BRN 0742880
C818L19FMP
DTXSID1020015
AI3-01560
NSC-2064
NSC-2847
C8-H10-N2-O
1-ACETYL-2-PHENYL HYDRAZIDE
MFCD00008672
NSC-229032
2-Acetyl-1-phenylhydrazine
DTXCID1015
CHEMBL30131
ACETYL-2-PHENYLHYDRAZINE, 1-
N(1)-ACETYLPHENYLHYDRAZINE [HSDB]
WLN: 1VMMR
N-Acetylphenylhydrazine
N-(phenylamino)acetamide
UNII-C818L19FMP
N'Phenylacethydrazide
Acetic phenylhydrazide
acetyl phenyl hydrazine
1Acetyl2phenylhydrazine
1Phenyl2acetylhydrazine
betaAcetylphenylhydrazine
N-Acetoylphenylhydrazone
NAcetylN'phenylhydrazine
N'-Phenylacetohydrazide #
1-acetyl-2-phenyl hydrazine
1-acetyl-2-phenyl-hydrazine
SCHEMBL425872
hydrazine, 1-acetyl-2-phenyl-
N'-phenyl-acetic acid hydrazide
Acetic acid N'-phenyl-hydrazide
UICBCXONCUFSOI-UHFFFAOYSA-
NSC2064
NSC2847
Acetic acid N''-phenyl-hydrazide
CHEBI:228483
Tox21_200069
BDBM50280201
NSC229032
STK400328
1-Acetyl-2-phenylhydrazine, >=98%
AKOS000119811
CS-W018141
FA00777
HY-W017425
AcPhHZ;Hydracetin;2-Phenylacetohydrazide
NCGC00090860-01
NCGC00090860-02
NCGC00257623-01
AS-12891
CAS-114-83-0
A0107
NS00006641
EN300-15535
F11205
1-acetyl-2-phenylhydrazine;2-Phenylacetohydrazide
Q2806574
Z27767717
InChI=1/C8H10N2O/c1-7(11)9-10-8-5-3-2-4-6-8/h2-6,10H,1H3,(H,9,11)
V8L