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N-phenylpropanamide

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Identification
Molecular formula
C9H11NO
CAS number
103-81-1
IUPAC name
N-phenylpropanamide
State
State

At room temperature, N-phenylpropanamide is a solid. It maintains a stable state under standard conditions, which includes both room temperature and pressure.

Melting point (Celsius)
109.00
Melting point (Kelvin)
382.15
Boiling point (Celsius)
295.00
Boiling point (Kelvin)
568.15
General information
Molecular weight
149.19g/mol
Molar mass
149.1880g/mol
Density
1.0845g/cm3
Appearence

N-phenylpropanamide appears as a white crystalline solid. It is characterized by its powder-like consistency and crystalline structure, typical of many amide compounds. The appearance may vary slightly from finely powdered to more granular crystal formations.

Comment on solubility

Solubility of N-phenylpropanamide

N-phenylpropanamide, with the chemical formula C9H11NO, exhibits a unique solubility profile due to its structural characteristics. As an amide compound, its solubility properties can be influenced by several factors:

  • Polarity: The presence of the amide functional group (–CONH2) contributes to the polarity of the molecule, which can enhance its solubility in polar solvents.
  • Hydrogen Bonding: N-phenylpropanamide is capable of forming hydrogen bonds, particularly with water, which typically aids in increasing its solubility in aqueous environments.
  • Temperature Dependency: The solubility of N-phenylpropanamide can vary with temperature; generally, higher temperatures may lead to increased solubility in certain solvents.
  • Solvent Interaction: It shows relatively good solubility in organic solvents such as ethanol and methanol, while solubility in water may be limited.

To summarize, solubility is a complex characteristic influenced notably by the functional groups and interactions within the molecule. As a result, while N-phenylpropanamide can dissolve in both polar and non-polar solvents to varying degrees, it may exhibit better solubility properties when interacting with solvents that can form hydrogen bonds.

Interesting facts

Interesting Facts about N-phenylpropanamide

N-phenylpropanamide, also known as phenylacetamide, is a fascinating compound that belongs to the class of amides. This compound boasts a variety of intriguing characteristics and applications that make it significant in both organic chemistry and industrial settings.

Applications and Uses

  • Pharmaceuticals: N-phenylpropanamide is often explored for its potential as a pharmaceutical intermediate, making it valuable in the development of various medicinal compounds.
  • Aromatics: The aromatic nature of the phenyl group contributes to the compound's use in synthesizing various dye and fragrance materials.
  • Agricultural Chemicals: It can also play a role in the formulation of agrochemicals, which are crucial for enhancing crop production.

Chemical Properties

This compound exhibits a key feature in organic synthesis, namely its ability to participate in reactions involving nucleophiles. As an amide, it has a carbonyl group that can act as a site for chemical reactions, allowing for the formation of a range of derivatives.

Structural Highlights

  • The presence of both an amine and a carbonyl group allows for strong dipole-dipole interactions, which influence its reactivity and solubility.
  • The phenyl group introduces unique electronic properties, making it susceptible to electrophilic substitution reactions, enhancing its utility in organic synthesis.

In Summary

N-phenylpropanamide is not just another organic compound. Its diverse applications in the pharmaceutical, agricultural, and chemical industries underline its importance. As researchers continue to explore its potential, this compound exemplifies the intricate connections between structure and function in the world of chemistry. To quote an important figure in chemistry, "The beauty of chemistry is in the complexities of the simple." N-phenylpropanamide stands as a prime example of this principle.

Synonyms
N-Phenylpropanamide
N-Phenylpropionamide
PROPIONANILIDE
Propanamide, N-phenyl-
NSC 58952
UNII-UYP5ZQI00T
UYP5ZQI00T
EINECS 210-649-3
BRN 2207039
R 50977
NSC-58952
DTXSID0060721
ZTHRQJQJODGZHV-UHFFFAOYSA-
4-12-00-00385 (Beilstein Handbook Reference)
N-PHENYLPROPANAMIDE [NFLIS-DRUG]
FENTANYL IMPURITY G [EP IMPURITY]
R-50977
REMIFENTANIL HYDROCHLORIDE IMPURITY O [EP IMPURITY]
N-PHENYLPROPANAMIDE (NFLIS-DRUG)
FENTANYL IMPURITY G (EP IMPURITY)
REMIFENTANIL HYDROCHLORIDE IMPURITY O (EP IMPURITY)
DTXCID1043207
inchi=1/c9h11no/c1-2-9(11)10-8-6-4-3-5-7-8/h3-7h,2h2,1h3,(h,10,11)
zthrqjqjodgzhv-uhfffaoysa-n
620-71-3
Propionamide, N-phenyl-
N-phenyl-propionamide
Methylacetanilid
Fentanyl Imp. G (EP); N-Phenylpropanamide; Fentanyl Impurity G; Remifentanil Hydrochloride Impurity O; Remifentanil Impurity O; Remifentanil Impurity O
N-Phenylpropanamide #
CH3CH2CONHPh
WLN: ZVMR
SCHEMBL9706
MLS001076193
CHEMBL1870645
SCHEMBL11880444
HMS2269F06
NSC58952
MFCD00092530
STK060543
AKOS000492800
FP26998
NCGC00247442-01
AS-57336
SMR000639131
DB-054050
A8585
NS00034902
E79449
EN300-218949
Propionanilide;N-Phenylpropionamide;NSC 58952
Q26840807