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N'-phenylpyridine-4-carboxamidine

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Identification
Molecular formula
C12H11N3
CAS number
152460-06-1
IUPAC name
N'-phenylpyridine-4-carboxamidine
State
State

The compound is typically a solid at room temperature, forming stable crystalline structures. Despite being a solid, it can be handled with appropriate safety measures due to its well-defined crystalline form.

Melting point (Celsius)
149.00
Melting point (Kelvin)
422.15
Boiling point (Celsius)
254.00
Boiling point (Kelvin)
527.15
General information
Molecular weight
195.24g/mol
Molar mass
195.2350g/mol
Density
1.2368g/cm3
Appearence

N'-Phenylpyridine-4-carboxamidine appears as a crystalline solid. The crystals may vary in color but are usually white to off-white. This compound is known for its crystalline nature, which can be observed in its standard solid state at room temperature.

Comment on solubility

Solubility of N'-phenylpyridine-4-carboxamidine

N'-phenylpyridine-4-carboxamidine is an intriguing compound with unique solubility characteristics. Its solubility can be influenced by a variety of factors, including:

  • Polarity: The presence of amine and carbonyl functional groups in the structure contributes to both polar and non-polar characteristics, affecting how it interacts with solvents.
  • Temperature: Like many organic compounds, solubility can increase with temperature, allowing for a higher dissolution rate in common organic solvents.
  • Solvent Choice: This compound is typically more soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO) than in water due to its hydrophobic aromatic ring.

However, as with many compounds, solubility can be limited by the following:

  • Hydrogen Bonding: Strong hydrogen bonding interactions with water molecules may hinder its ability to dissolve in aqueous environments.
  • Complexation: The potential to form complexes with metal ions or other substances may also impact solubility in certain contexts.

In conclusion, while N'-phenylpyridine-4-carboxamidine exhibits limited solubility in water, its solubility in organic solvents is relatively significant. Understanding these nuances of solubility is critical for its application in various chemical environments.

Interesting facts

Interesting Facts About N'-Phenylpyridine-4-Carboxamidine

N'-Phenylpyridine-4-carboxamidine is a fascinating compound that holds significant importance in various fields, particularly in medicinal and agricultural chemistry.

  • Pharmaceutical Potential: This compound exhibits promising biological activities, making it a subject of interest in drug development. Its structural features can lead to the creation of novel pharmaceuticals with enhanced efficacy.
  • Biological Activity: Research has shown that compounds similar to N'-phenylpyridine-4-carboxamidine may have antitumor and antibacterial properties. This positions it as a potential candidate for further exploration in therapeutic applications.
  • Chemical Versatility: The nitrogen in the amidine functional group contributes to the compound's reactivity, allowing it to participate in a variety of chemical reactions, like cross-coupling and synthesis of larger molecular frameworks.
  • Research Applications: Scientists are investigating the use of this compound in heterocyclic chemistry, where modifications of the pyridine ring can yield compounds with diverse activities. This opens up new avenues for discovery in synthetic chemistry.
  • Structure-Activity Relationship (SAR): Understanding how structural variations of this compound affect its activity is crucial. Scientists utilize SAR studies to identify which modifications can enhance its desired properties.

In conclusion, N'-phenylpyridine-4-carboxamidine showcases a blend of chemical uniqueness and biological relevance, making it an exciting compound for ongoing research. With its myriad applications ranging from pharmaceuticals to agriculture, the pursuit of further knowledge about this compound continues to be an engaging challenge for chemists.

Synonyms
N-Phenylisonicotinamidine
23573-51-5
ISONICOTINAMIDINE, N-PHENYL-
BRN 0473961
4-Pyridinecarboximidamide, N-phenyl-
DTXSID80178211
RefChem:349665
DTXCID10100702
N'-phenylpyridine-4-carboximidamide
DA-43116