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Iodixanol

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Identification
Molecular formula
C35H44I6N6O15
CAS number
92339-11-2
IUPAC name
N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N3-methyl-benzene-1,3-dicarboxamide
State
State

At room temperature, Iodixanol is typically found in a solid state as a crystalline powder. However, for its use as an X-ray contrast medium, it is dissolved to form a solution.

Melting point (Celsius)
167.80
Melting point (Kelvin)
440.95
Boiling point (Celsius)
746.58
Boiling point (Kelvin)
1 019.73
General information
Molecular weight
1550.20g/mol
Molar mass
1 550.1980g/mol
Density
1.6200g/cm3
Appearence

Iodixanol appears as a white or almost white crystalline powder. It is highly soluble in water, which is essential for its function as a contrast agent.

Comment on solubility

Solubility of N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N3-methyl-benzene-1,3-dicarboxamide

The solubility of N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N3-methyl-benzene-1,3-dicarboxamide (C35H44I6N6O15) in various solvents offers insights into its potential applications and utility. Solubility is a crucial property that determines how a compound can integrate into biological systems and chemical processes.

This compound's large macromolecular structure, which includes multiple functional groups, plays a significant role in its solubility behavior. The following factors are noteworthy:

  • Polarity: The presence of hydroxyl (-OH) groups increases the *hydrophilicity*, suggesting higher solubility in polar solvents such as water.
  • Hydrophobic regions: The presence of iodine atoms can contribute to *hydrophobic interactions*, potentially diminishing solubility in aqueous environments.
  • Functional groups: The dicarboxamide moiety enhances solubility in polar solvents due to hydrogen bonding capabilities.
  • Concentration dependencies: As with many organic compounds, solubility can vary with temperature and concentration, showing that various forms may exist under different conditions.

In summary, understanding the solubility of this complex compound is not merely an academic exercise; it serves as a foundation for its potential applications in pharmaceuticals, materials science, and biochemistry. As the *saying goes*, "Solubility is the key to efficacy," underscoring the importance of comprehensively studying this property.

Interesting facts

Interesting Facts about N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N3-methyl-benzene-1,3-dicarboxamide

The compound N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N3-methyl-benzene-1,3-dicarboxamide is a fascinating chemical due to its complex structure and potential applications in various fields. Here are several intriguing aspects:

  • Multifunctionality: This compound contains multiple functional groups, making it a candidate for various chemical reactions and applications in medicinal chemistry.
  • Iodine Richness: With three iodine atoms in its structure, this compound exhibits properties that can be particularly useful in imaging techniques, such as Computed Tomography (CT scans), due to the high X-ray attenuation characteristic of iodine.
  • Therapeutic Potential: Derivatives of this compound may have potential therapeutic effects, owing to their ability to form hydrogen bonds and interact with biological targets, making them interesting for drug design and development.

Applications and Impacts

The compound's structure showcases a balance of hydrophilic and hydrophobic characteristics, which can influence its biodistribution in a biological system. Here are some of its significant implications:

  • Drug Delivery Systems: The ability to modify the compound's solubility and stability may allow it to be utilized in targeted drug delivery.
  • Research Applications: It may serve as a tool in biochemistry and molecular biology research, helping scientists understand complex biochemical pathways.
  • Contrast Agents in Imaging: Due to its iodine content, it could potentially be developed into advanced contrast agents in medical imaging, offering higher specificity and lower toxicity.

In conclusion, the compound N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N3-methyl-benzene-1,3-dicarboxamide stands at the forefront of chemical innovation. As we continue to explore and understand such compounds, who knows what discoveries await us? As chemist Robert H. Grubbs once said, "Innovation is a powerful force in science; only with innovation can we unlock the secrets of the universe."

Synonyms
iopromide
73334-07-3
Ultravist
Iopromidum
Iopromida
Ultravist 300
Proscope
Ultravist 370
N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-methoxyacetamido)-N1-methylisophthalamide
iopromid
ZK 35760
SHL 414C
Ultravist 150
Ultravist 240
Iopromidum [INN-Latin]
Iopromida [INN-Spanish]
Ultravist (pharmacy bulk)
EINECS 277-385-9
UNII-712BAC33MZ
BRN 7085608
712BAC33MZ
DTXSID0023163
ZK-35760
CHEBI:63578
N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-methoxyacetamido)-N-methylisophthalamide
BAY86-4877
BAY 86-4877
DTXCID503163
1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-3-N-methylbenzene-1,3-dicarboxamide
Iopromide [USAN:USP:INN:BAN]
Ultravist 300 In Plastic Container
n,n'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-n-methylisophthalamide
1,3-Benzenedicarboxamide, N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-((methoxyacetyl)amino)-N-methyl-
Iopromidum (INN-Latin)
Iopromida (INN-Spanish)
IOPROMIDE (MART.)
IOPROMIDE [MART.]
IOPROMIDE (USP-RS)
IOPROMIDE [USP-RS]
1,3-Benzenedicarboxamide, N,N'-bis(2,3-dihydroxypropyl)-5-((methoxyacetyl)amino)-N-methyl-2,4,6-triiodo-
IOPROMIDE (EP IMPURITY)
IOPROMIDE [EP IMPURITY]
IOPROMIDE (EP MONOGRAPH)
IOPROMIDE [EP MONOGRAPH]
IOPROMIDE (USP MONOGRAPH)
IOPROMIDE [USP MONOGRAPH]
lopromid
Iopromide (USAN:USP:INN:BAN)
C18H24I3N3O8
Ultravist (TN)
NCGC00016923-01
Proscope (TN)
N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-((methoxyacetyl)amino)-N-methylisophthalamide
CAS-73334-07-3
MFCD00867924
Iopromide (Standard)
IOPROMIDE [INN]
IOPROMIDE [JAN]
IOPROMIDE [MI]
IOPROMIDE [USAN]
Prestwick0_000872
Prestwick1_000872
Prestwick2_000872
Prestwick3_000872
IOPROMIDE [VANDF]
IOPROMIDE [WHO-DD]
CHEMBL1725
Iopromide (JAN/USP/INN)
SCHEMBL24546
BSPBio_000943
MLS002154045
Iopromide, analytical standard
SPBio_002864
BPBio1_001039
IOPROMIDE [ORANGE BOOK]
SCHEMBL23673810
HY-B1362R
V08AB05
HMS1570P05
HMS2097P05
HMS2233O23
HMS3370M05
HMS3714P05
BCP08449
HY-B1362
Tox21_110684
AC-535
s3207
AKOS025402129
Tox21_110684_1
CCG-220872
DB09156
FI35019
Iopromid 100 microg/mL in Acetonitrile
NCGC00179367-01
NCGC00179367-03
BS-17441
DA-64476
SMR001233368
AB00513942
CS-0013103
NS00000230
A12801
D01893
EN300-19767813
SR-01000841262
Q4202805
SR-01000841262-2
BRD-A72075775-001-10-4
BRD-A72075775-001-11-2
Z2681890595
Iopromide, European Pharmacopoeia (EP) Reference Standard
Iopromide, United States Pharmacopeia (USP) Reference Standard
Iopromide for system suitability 1, European Pharmacopoeia (EP) Reference Standard
Iopromide for system suitability 2, European Pharmacopoeia (EP) Reference Standard
1,3-Benzenedicarboxamide, N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N1-methyl-
277-385-9
N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-N-methyl-5-{[(methyloxy)acetyl]amino}benzene-1,3-dicarboxamide
N-(2,3-dihydroxypropyl)-3-[(2,3-dihydroxypropyl)(methyl)carbamoyl]-5-[(1-hydroxy-2-methoxyethylidene)amino]-2,4,6-triiodobenzene-1-carboximidic acid
N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-methoxyacetamido)-N1-methylbenzene-1,3-dicarboxamide