Skip to main content

iohexol

ADVERTISEMENT
Identification
Molecular formula
C19H26I3N3O9
CAS number
66108-95-0
IUPAC name
N1,N3-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-methyl-amino]-2,4,6-triiodo-benzene-1,3-dicarboxamide
State
State

At room temperature, iohexol is typically in a solid state as a crystalline powder.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
425.00
Boiling point (Kelvin)
698.15
General information
Molecular weight
821.14g/mol
Molar mass
821.1390g/mol
Density
1.3827g/cm3
Appearence

Iohexol appears as a white or almost white crystalline powder. It is hygroscopic, meaning it can absorb moisture from the environment. When dissolved in water, it forms a clear, iodine-rich solution used in radiographic contrast media for medical imaging.

Comment on solubility

Solubility of N1,N3-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-methyl-amino]-2,4,6-triiodo-benzene-1,3-dicarboxamide

The solubility of the compound N1,N3-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-methyl-amino]-2,4,6-triiodo-benzene-1,3-dicarboxamide (C19H26I3N3O9) is influenced by its complex structure, which incorporates multiple functional groups that can interact with solvents in various ways.

Key points regarding its solubility include:

  • Polar Functional Groups: The presence of multiple hydroxyl (-OH) groups and amines tend to increase solubility in polar solvents, particularly water.
  • Iodine Content: The significant iodine substitution may lead to hydrophobic characteristics that could limit solubility in non-polar solvents.
  • Hydrogen Bonding: The compound's ability to form hydrogen bonds with water can enhance its solubility in aqueous environments.
  • pH Dependence: The solubility might vary with pH, as the ionization of the amine groups could affect solubility in different pH conditions.

In summary, while N1,N3-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-methyl-amino]-2,4,6-triiodo-benzene-1,3-dicarboxamide is potentially soluble in polar solvents due to its hydroxyl and amine groups, the presence of iodine could limit its solubility in non-polar environments. Therefore, understanding its solubility is critical for applications that involve dissolution in various solvents.

Interesting facts

Exploring N1,N3-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-methyl-amino]-2,4,6-triiodo-benzene-1,3-dicarboxamide

N1,N3-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-methyl-amino]-2,4,6-triiodo-benzene-1,3-dicarboxamide is a fascinating compound within the realm of organic chemistry, particularly due to its iodine content and multifunctional framework. This compound belongs to a class often referred to as iodinated aromatic compounds, which have significant applications in various fields such as medicine and imaging diagnostics.

Key Characteristics

  • Iodine Content: The presence of three iodine atoms makes this compound highly relevant in medical imaging, particularly in enhancing the contrast in X-ray and CT scans.
  • Functional Groups: This compound features multiple hydroxyl and carboxamide groups, contributing to its versatile reactivity and potential for forming various derivatives.
  • Biological Activity: The structure suggests potential biological applications, possibly as a drug or a therapeutic agent, exploring its efficacy in targeting certain diseases.

Interesting Insights

One of the notable aspects of this compound is its potential interaction with biological molecules due to its complex structure. As a scientist or a student, you might find it interesting to study:

  • The mechanism of action of iodinated compounds in medical imaging.
  • How the introduction of various functional groups can influence chemical reactivity and biological interactions.
  • The synthesis routes that can yield this compound, which often involve intricate organic reactions, showcasing the beauty of synthetic methodology.

This compound not only highlights the intricate dance of atoms and functional groups but also serves as a reminder of the potential applications that can arise from understanding such complex chemical entities. Researchers continue to delve into its properties, unveiling new uses and expanding the frontier of knowledge in organic chemistry.

Synonyms
iomeprol
78649-41-9
Iomeprolum
Iomeron
Iomeprolo
Imeron
Iomeron 300
Iomeprolum [INN-Latin]
UNII-17E17JBP8L
E-7337
N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(N-methylglycolamido)isophthalamide
17E17JBP8L
N1,N3-Bis(2,3-dihydroxypropyl)-5-(2-hydroxy-N-methylacetamido)-2,4,6-triiodoisophthalamide
DTXSID1049061
CHEBI:31710
1185146-41-1
1-N,3-N-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-methylamino]-2,4,6-triiodobenzene-1,3-dicarboxamide
DTXCID2028987
E7337
N,N'-bis(2,3-dihydroxypropyl)-5-[glycoloyl(methyl)amino]-2,4,6-triiodoisophthalamide
1,3-Benzenedicarboxamide, N,N'-bis(2,3-dihydroxypropyl)-5-((hydroxyacetyl)methylamino)-2,4,6-triiodo-
NCGC00183283-01
Iomeprolum (INN-Latin)
IOMEPROL (MART.)
IOMEPROL [MART.]
Iomeprol 100 microg/mL in Acetonitrile/Methanol
Iomeprol [USAN:INN:BAN:JAN]
Iomeprol Injection
N,N'-bis(2,3-dihydroxypropyl)-5-(glycoloyl(methyl)amino)-2,4,6-triiodoisophthalamide
Iomervu (TN)
IOMERVU
IOMEPROL [USAN]
IOMEPROL [INN]
IOMEPROL [JAN]
IOMEPROL [MI]
Iomeron 300 (TN)
IOMEPROL [WHO-DD]
SCHEMBL26981
Iomeprol (JAN/USAN/INN)
CHEMBL2107214
V08AB10
BCP34386
Tox21_113611
AKOS030255901
AT46190
DB11705
AC-30722
CAS-78649-41-9
DB-056324
HY-150137
CS-0612179
methylacetamido)-2,4,6-triiodoisophthalamide
NS00000228
D01719
SBI-0654159.0001
B-16880
EN300-19767832
N1,N3-bis(2,3-dihydroxypropyl)-5-(2-hydroxy-N-
Q6062808
N,N'-Bis(2,3-dihydroxypropyl)-5-(2-hydroxy-N-methylacetamido)-2,4,6-triiodoisophthalamide
1,3-Benzenedicarboxamide, N1,N3-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)methylamino]-2,4,6-triiodo-
N1,N3-bis(2,3-dihydroxypropyl)-5-(2-hydroxy-N-methylacetamido)-2,4,6-triiodobenzene-1,3-dicarboxamide