Interesting facts
Interesting Facts about N,3-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine
This compound, commonly referred to in academic circles as a member of the oxazaphosphorine family, has garnered significant attention due to its unique structure and diverse potential applications. Here are some compelling insights:
- Pharmaceutical Relevance: Compounds of this kind often demonstrate properties that are valuable in medicinal chemistry, particularly in the development of anticancer agents. Their ability to target and interfere with DNA replication makes them crucial in the field of oncology.
- Mechanism of Action: The presence of the 2-chloroethyl moiety is particularly noteworthy. It is known to form reactive species that can alkylate DNA, leading to cell death—a mechanism that is central to the efficacy of many chemotherapeutic agents.
- Material Science Applications: Beyond its pharmaceutical uses, this compound may find roles in the development of new materials. Its phosphorus-containing structure allows for the enhancement of materials with desirable fire-retardant properties.
- Environmental Considerations: The toxicity associated with chlorine-containing compounds has led to increased scrutiny regarding their environmental impact. Studies on the degradation pathways of compounds like this highlight the importance of responsible usage and disposal methods.
- Novel Synthetic Pathways: The synthesis of such complex molecules often requires creative and novel methodologies. Researchers continually explore new routes to minimize environmental impact and improve yields in the production of this compound.
The exploration of N,3-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine exemplifies the intersection of chemistry, pharmacology, and environmental science. As we delve deeper into the properties and implications of this compound, we may uncover novel applications that could significantly impact multiple fields.
Synonyms
ifosfamide
Isophosphamide
3778-73-2
Iphosphamide
Isofosfamide
Ifex
Ifosfamid
Mitoxana
Iphosphamid
Isoendoxan
Naxamide
I-Phosphamide
Cyfos
Holoxan
Ifsofamide
Holoxan 1000
Ifosfamida
ASTA Z 4942
Ifosfamidum
MJF 9325
isosfamide
MJF-9325
NCI-C01638
ifomide
NSC-109724
Z4942
Z-4942
Ifosfamidum [INN-Latin]
Ifosfamida [INN-Spanish]
2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide
A 4942
Z 4942
CCRIS 352
NSC 109724
HSDB 7023
ISOCYCLOPHOSPHAMIDE
UNII-UM20QQM95Y
N,3-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
3-(2-Chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
EINECS 223-237-3
UM20QQM95Y
MFCD00057374
N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid diamide
BRN 0611835
CHEBI:5864
DTXSID7020760
3-(2-chloroethyl)-2-((2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide
3-(2-Chloroethyl)-2-(2-chloroethylamino)tetrahydro-2H-1,3,2-oxaazaphosphorin 2-oxide
NSC109724
2,3-(N,N(sup 1)-Bis(2-chloroethyl)diamido)-1,3,2-oxazaphosphoridinoxyd
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorineoxide
DTXCID90760
N,N-Bis(beta-chloroethyl)-amino-N',O-propylene-phosphoric acid ester diamide
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide
1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide
2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide
3-(2-Chloroethyl)-2-((2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine oxide
Ifosphamide
Iso-Endoxan
N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide
Ifosfamide [USAN:USP:INN:BAN:JAN]
NCGC00016639-01
CAS-3778-73-2
Ifosfamidum (INN-Latin)
Iso Endoxan
Ifosfamida (INN-Spanish)
IFOSFAMIDE (MART.)
IFOSFAMIDE [MART.]
Ifosfamide Sterile
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
IFOSFAMIDE (USP-RS)
IFOSFAMIDE [USP-RS]
ISOPHOSPHAMIDE (IARC)
ISOPHOSPHAMIDE [IARC]
66849-34-1
IFOSFAMIDE (EP IMPURITY)
IFOSFAMIDE [EP IMPURITY]
IFOSFAMIDE (EP MONOGRAPH)
IFOSFAMIDE [EP MONOGRAPH]
IFOSFAMIDE (USP MONOGRAPH)
IFOSFAMIDE [USP MONOGRAPH]
Ifosfamide (USAN:USP:INN:BAN:JAN)
(R)-3-(2-chloroethyl)-2-((2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide
3-(2-chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2lambda5-oxazaphosphinan-2-one
(2-CHLORO-ETHYL)-[(R)-3-(2-CHLORO-ETHYL)-2-OXO-2LAMBDA5-[1,3,2]OXAZAPHOSPHINAN-2-YL]-AMINE
SR-05000002022
IFEX (TN)
Holoxane
Ifomida
Ifosfamide (JAN/USP/INN)
Seromida
Tronoxal
Ifolem
Ifoxan
N,3-bis(2-chloroethyl)-2-oxo-1,3,2|E5-oxazaphosphinan-2-amine
Ifosfamid A
3-(2-Chloroethyl)-2-((2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorineoxide
Ifosfamide; (RS)-N,3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
Ifosfamide in bulk
IFO-Cell
Isophosphamide,(S)
N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid [German]
Ifosfamide (Standard)
starbld0001221
Ifosfamide, >=98%
IFOSFAMIDE [MI]
IFOSFAMIDE [INN]
IFOSFAMIDE [JAN]
Prestwick0_000833
Prestwick1_000833
Prestwick2_000833
Prestwick3_000833
IFOSFAMIDE [HSDB]
IFOSFAMIDE [USAN]
IFOSFAMIDE [VANDF]
Asta Z-4942
SCHEMBL4885
CHEMBL1024
IFOSFAMIDE [WHO-DD]
BSPBio_000785
MLS002154021
Ifex (TN) (Bristol Meyers)
SPBio_002706
BPBio1_000865
GTPL7201
Ifosfamide - Bio-X trade mark
NCI-CO1638
IFOSFAMIDE [ORANGE BOOK]
L01AA06
BDBM189358
HMS1570H07
HMS2090M12
HMS2093N07
HMS2097H07
HMS2232O10
HMS3374B08
HMS3654B15
HMS3714H07
Pharmakon1600-01505480
{3-(2-Chloroethyl)-2-[(2-
BCP06596
WLN: T6NPOTJ AM2G BO B2G
Tox21_110539
Tox21_201815
Tox21_302775
BBL028071
HY-17419R
N,3-bis(2-chloroethyl)-2-oxo-1,3,2$l^{5}-oxazaphosphinan-2-amine
N,3-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine
NSC759154
s1302
STL058690
AKOS005711213
N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide
Tox21_110539_1
AB02316
AC-2113
CCG-213464
CS-1424
DB01181
FB24538
NSC-759154
N-(2-Chloroethyl)-N-(3-(2-chloroethyl)-2-oxido-1,3,2-oxazaphosphinan-2-yl)amine
NCGC00179435-01
NCGC00179435-02
NCGC00179435-03
NCGC00179435-06
NCGC00179435-07
NCGC00256413-01
NCGC00259364-01
AS-10978
BI166243
HY-17419
NCI60_000233
SMR001233348
SY066721
SBI-0206804.P001
DB-049196
AB00513932
I0713
NS00000356
SW197177-4
C07047
D00343
AB00513932-06
AB00513932-07
AB00513932-08
AB00513932_09
AB00513932_10
EN300-7476797
Q418560
SR-05000002022-1
SR-05000002022-3
SR-05000002022-5
BRD-A67097164-001-11-2
BRD-A67097164-001-17-9
BRD-A67097164-001-18-7
Ifosfamide, British Pharmacopoeia (BP) Reference Standard
Ifosfamide, European Pharmacopoeia (EP) Reference Standard
Ifosfamide, United States Pharmacopeia (USP) Reference Standard
2,N(sup 1)-Bis(2-chloroethyl)diamido-1,3,2-oxazaphosphoridinoxy-
2,N(sup 1)-Bis(2-chloroethyl)diamido-1,3,2-oxazaphosphoridinoxyd
2,3-(N,N(,)-BIS(2-CHLOROETHYL)DIAMIDO)-1,3,2-OXAZAPHOSPHORIDINOXY
N,3-bis(2-chloroethyl)-2-oxo-1,3,2$l;{5}-oxazaphosphinan-2-amine
{3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,} 2-oxazaphosphorine oxide
1,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide
2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine
2H-1,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide
2H-1,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide
3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide
3-(2-chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2$l^{5}-oxazaphosphinan-2-one
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,2-oxazaphosphorine oxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,2-oxazaphosphorineoxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,2-oxazaphosphorine 2-oxide
N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphinan-2-amine 2-oxide #
N,N-BIS(BETA-CHLOROETHYL)-AMINO-N'-O-PROPYLENE-PHOSPHORIC ACID ESTER DIAMIDE
N-(2-CHLORAETHYL)-N'-(2 CHLOROETHYL)-N'-o-PROPYLEN-PHOSPHORSAEUREESTER-DIAMID
223-237-3
3-(2-CHLOROETHYL)-2-((2-CHLOROETHYL)AMINO)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE-2 -OXIDE
N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide;A 4942;Asta Z 4942
Solubility of N,3-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine
The solubility of N,3-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine (C7H15Cl2N2O2P) can be understood through various factors:
However, this compound is relatively complex, which may introduce challenges in predicting its solubility without empirical data. Based on its structure, one might summarize:
The solubility can be categorized as moderate in polar solvents while likely being limited in non-polar environments.Understanding the solubility of such compounds is vital for their application in various chemical processes and pharmaceutical formulations.