Chloroquine

Identification

Molecular formula

C₁₈H₂₆ClN₃

CAS number

54-05-7

IUPAC name

N4-(7-chloro-4-quinolyl)-N1,N1-diethyl-pentane-1,4-diamine

State

At room temperature, chloroquine is found in a solid state, typically as a powder or crystalline particles. It is stable under standard conditions.

Melting point (Celsius)

87.00

Melting point (Kelvin)

360.00

Boiling point (Celsius)

360.00

Boiling point (Kelvin)

633.00

General information

Molecular weight

319.87g/mol

Molar mass

319.8720g/mol

Density

1.2500g/cm³

Appearence

Chloroquine is typically encountered as a white to slightly yellow, crystalline powder. The compound is both odorless and has a bitter taste, distinguishing its sensory properties in physical handling and testing.

Comment on solubility

Solubility Characteristics of N⁴-(7-chloro-4-quinolyl)-N¹,N¹-diethyl-pentane-1,4-diamine

The solubility of N⁴-(7-chloro-4-quinolyl)-N¹,N¹-diethyl-pentane-1,4-diamine (C₁₈H₂₆ClN₃) can vary significantly depending on various factors such as temperature, pH, and solvent type. Here are some key points to consider:

Polarity: This compound contains a chlorine atom, which can increase its polarity. This may suggest limited solubility in nonpolar solvents.
Hydrogen Bonding: With amine groups present, it is likely that N⁴-(7-chloro-4-quinolyl)-N¹,N¹-diethyl-pentane-1,4-diamine can engage in hydrogen bonding, potentially improving its solubility in polar solvents such as water or alcohols.
Solvent Compatibility: The choice of solvent can greatly affect solubility. For instance:
- Good solubility in alcohols may be expected due to the potential for hydrogen bonding.
- Limited solubility in hydrocarbons or other nonpolar solvents is likely.
Temperature Effects: Generally, solubility increases with temperature, so higher temperatures may enhance the dissolution of this compound in suitable solvents.

In conclusion, while the specific solubility data for N⁴-(7-chloro-4-quinolyl)-N¹,N¹-diethyl-pentane-1,4-diamine may not be readily available, understanding these general principles can help in predicting its behavior in various solvent systems.

Interesting facts

Interesting Facts about N⁴-(7-chloro-4-quinolyl)-N¹,N¹-diethyl-pentane-1,4-diamine

N⁴-(7-chloro-4-quinolyl)-N¹,N¹-diethyl-pentane-1,4-diamine is a fascinating compound that has garnered attention in the field of medicinal chemistry. Here are some noteworthy points:

Structure & Functionality: This compound features a quinoline moiety, known for its diverse biological activities, which contributes to its potential as a pharmaceutical agent.
Biosynthetic Interest: The presence of the chloro group enhances its reactivity, making it a subject of interest for synthetic organic chemists pursuing new derivatives with improved efficacy.
Pharmacology: Compounds like this are often explored for their ability to interact with various biological targets, including enzymes and receptors, making them candidates for therapeutic applications in treating diseases.
Research Developments: Studies have indicated that the quinoline derivatives can exhibit antimalarial, antimicrobial, and anticancer properties, thus holding promise in diverse medical applications.
Environmental Considerations: As research continues, understanding the environmental impact and degradation pathways of such nitrogen-containing compounds is critical in the development of sustainable practices.

In summary, N⁴-(7-chloro-4-quinolyl)-N¹,N¹-diethyl-pentane-1,4-diamine stands out as a unique structure within the realm of organic compounds, merging functionality with potential medicinal benefits. Its ongoing study may yield novel insights into compound reactivity and their applications in health and disease management.

Synonyms

chloroquine

54-05-7

Aralen

Chlorochin

Chloraquine

Artrichin

Chloroquina

Chloroquinium

Capquin

Reumachlor

Chemochin

Chlorquin

Clorochina

Malaquin

Bemaco

Arthrochin

Bemasulph

Chingamin

Cidanchin

Cocartrit

Dichinalex

Gontochin

Pfizerquine

Quinachlor

Quinercyl

Quinoscan

Tresochin

Benaquin

Bipiquin

Elestol

Heliopar

Iroquine

Klorokin

Lapaquin

Malaren

Mesylith

Neochin

Quinilon

Roquine

Sanoquin

Silbesan

Siragan

Solprina

Sopaquin

Trochin

Amokin

Imagon

Nivaquine B

Bemaphate

Cloroquina

Resoquine

Malarex

Chloroquinum

Ronaquine

Nivaquine

Chlorochine

Chlorochinum

Quinagamine

Khingamin

N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine

Avlochlor

Nivachine

Quinagamin

Quingamine

Resochen

Resoquina

Reumaquin

WIN 244

Delagil

ST 21 (pharmaceutical)

RP 3377

1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-

Chloroquinum [INN-Latin]

Cloroquina [INN-Spanish]

W 7618

(+-)-Chloroquine

CCRIS 3439

CHEBI:3638

HSDB 3029

7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline

N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine

{4-[(7-chloroquinolin-4-yl)amino]pentyl}diethylamine

EINECS 200-191-2

UNII-886U3H6UFF

Chloroin

Miniquine

Rivoquine

Tanakene

Arolen

NSC 187208

NSC-187208

BRN 0482809

886U3H6UFF

4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine

Gontochin phosphate

CHEMBL76

MFCD00024009

SN 6718

Chloroquine [USP:INN:BAN]

Ipsen 225

N(sup 4)-(7-Chloro-4-quinolinyl)-N(sup 1),N(sup 1)-diethyl-1,4-pentanediamine

DTXSID2040446

7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline

Quinoline, 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)-

1,4-Pentanediamine, N(4)-(7-chloro-4-quinolinyl)-N(1),N(1)-diethyl-

NSC187208

SN 7618

Chloroquine (VAN)

Clorochina [DCIT]

N(4)-(7-chloro-4-quinolinyl)-N(1),N(1)-diethyl-1,4-pentanediamine

Chloroquinum (INN-Latin)

Cloroquina (INN-Spanish)

3377 RP

1,4-Pentanediamine, N(sup 4)-(7-chloro-4-quinolinyl)-N(sup 1),N(sup 1)-diethyl-

CHLOROQUINE (MART.)

CHLOROQUINE [MART.]

Chloroquine (USP:INN:BAN)

1246815-14-4

3377 RP opalate

Chloroquin

CHLOROQUINE (USP IMPURITY)

CHLOROQUINE [USP IMPURITY]

CHLOROQUINE (USP MONOGRAPH)

CHLOROQUINE [USP MONOGRAPH]

Quinoline, 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-

N(4)-(7-chloroquinolin-4-yl)-N(1),N(1)-diethylpentane-1,4-diamine

1,4-PENTANEDIAMINE, N(SUP 4)-(7-CHLORO-4-QUINOLINYL)-N(SUP 1),N (SUP 1)-DIETHYL-

NSC14050

Chloroquine (USP/INN)

Malaquin (*Diphosphate*)

Cloroquine

Chloroquine, 17

Arechin (Salt/Mix)

Delagil (Salt/Mix)

Tanakan (Salt/Mix)

RP-3377

Bemaphate (Salt/Mix)

Resoquine (Salt/Mix)

Chloroquine (Standard)

Spectrum_000132

Chloroquine + Proveblue

CHLOROQUINE [MI]

Prestwick0_000548

Prestwick1_000548

Prestwick2_000548

Prestwick3_000548

Spectrum2_000127

Spectrum3_000341

Spectrum4_000279

Spectrum5_000707

CHLOROQUINE [INN]

(.+/-.)-Chloroquine

CHLOROQUINE [HSDB]

Epitope ID:131785

MolMap_000009

CHLOROQUINE [VANDF]

SCHEMBL8933

Lopac0_000296

BSPBio_000595

BSPBio_002001

CHLOROQUINE [WHO-DD]

KBioGR_000778

KBioSS_000592

DivK1c_000404

CU-01000012392-2

SPBio_000174

SPBio_002516

GNF-Pf-4216

BPBio1_000655

GTPL5535

DTXCID0020446

BDBM22985

KBio1_000404

KBio2_000592

KBio2_003160

KBio2_005728

KBio3_001221

P01BA01

NINDS_000404

HMS2090O03

HY-17589AR

N4-(7-chloro-4-quinolyl)-N1,N1-diethyl-pentane-1,4-diamine

ALBB-025694

HY-17589A

s6999

AKOS015935106

CCG-204391

CS-W004760

DB00608

KH-0005

SB73098

SDCCGSBI-0050284.P005

IDI1_000404

SMP2_000034

NCGC00015256-02

NCGC00015256-03

NCGC00015256-04

NCGC00015256-05

NCGC00015256-06

NCGC00015256-07

NCGC00015256-08

NCGC00015256-09

NCGC00015256-10

NCGC00015256-13

NCGC00015256-17

NCGC00015256-28

NCGC00162120-01

DA-51857

FC150960

NCI60_000894

SY086904

WLN: T66 BNJ EMY1&3N2&2 IG

SBI-0050284.P004

AB00053436

C3730

CS-0021871

NS00001540

C07625

D02366

EN300-120683

MLS-0466768.0001

AB00053436-05

AB00053436_06

AB00053436_07

1, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-

Q422438

BRD-A91699651-065-01-1

BRD-A91699651-316-06-7

BRD-A91699651-316-09-1

BRD-A91699651-316-10-9

BRD-A91699651-316-11-7

(7-Chloro-4-(4-diethylamino-1-methylbutylamino)-quinoline

n(sup4)-(7-chloro-4-quinolinyl)-n(sup1),4-pentanediamine

quinoline, 7-chloro-4-(4-diethylamino-1-methyl)butylamino-

N'-(7-chloroquinolin-4-yl)-N,N-diethylpentane-1,4-diamine

Quinoline, 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-

7-CHLORO-N-[5-(DIETHYLAMINO)PENTAN-2-YL]QUINOLIN-4-AMINE

N~4~-(7-chloroquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine

1,4-pentanediamine, N~4~-(7-chloro-4-quinolinyl)-N~1~,N~1~-diethyl-, phosphate (1:2)

7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline;(+/-)-Chloroquine

N(sup4)-(7-chloro-4-quinolinyl)-N(sup1),N(sup1)-diethyl-1,4-pentanediamine

117399-83-4

200-191-2

Solubility Characteristics of N4-(7-chloro-4-quinolyl)-N1,N1-diethyl-pentane-1,4-diamine

Interesting Facts about N4-(7-chloro-4-quinolyl)-N1,N1-diethyl-pentane-1,4-diamine

Solubility Characteristics of N⁴-(7-chloro-4-quinolyl)-N¹,N¹-diethyl-pentane-1,4-diamine

Interesting Facts about N⁴-(7-chloro-4-quinolyl)-N¹,N¹-diethyl-pentane-1,4-diamine