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NDMA (N-Nitrosodimethylamine)

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Identification
Molecular formula
C8H10N2O3S
CAS number
62-75-9
IUPAC name
N,4-dimethyl-N-nitroso-benzenesulfonamide
State
State

Under standard conditions, NDMA (N-Nitrosodimethylamine) is typically found as a liquid, although it can also be detected as a vapor due to its volatility.

Melting point (Celsius)
-51.00
Melting point (Kelvin)
222.15
Boiling point (Celsius)
151.00
Boiling point (Kelvin)
424.15
General information
Molecular weight
164.20g/mol
Molar mass
164.1970g/mol
Density
1.2400g/cm3
Appearence

NDMA is typically a yellow, oily liquid. It can also appear in different forms depending on purity and environmental conditions. In its pure form, it may exist as a colorless or pale yellow liquid.

Comment on solubility

Solubility of N,4-dimethyl-N-nitroso-benzenesulfonamide

N,4-dimethyl-N-nitroso-benzenesulfonamide is a fascinating compound with intriguing solubility properties. In general, the solubility of a chemical compound can significantly affect its behavior in various environments, and this compound is no exception.

When considering solubility, it is essential to note the following factors:

  • Polarity: The presence of both the nitroso and sulfonamide functional groups contributes to the compound's overall polarity, which can enhance its solubility in polar solvents.
  • Hydrogen Bonding: The sulfonamide moiety is capable of engaging in hydrogen bonding, which can facilitate solubility in water and other hydrogen-bonding solvents.
  • Solvent Effects: The solubility of N,4-dimethyl-N-nitroso-benzenesulfonamide may vary significantly between different solvents, with increased solubility observed in polar aprotic solvents.

In practical terms, researchers often find that:

  • Water Solubility: Limited water solubility can be expected, making it crucial for experiments that require aqueous environments.
  • Organic Solvents: The compound is likely more soluble in organic solvents like ethanol, methanol, or dimethyl sulfoxide (DMSO).

In summary, the solubility of N,4-dimethyl-N-nitroso-benzenesulfonamide is influenced by its molecular structure and the nature of the solvent. As with many sulfonamides, the intermolecular interactions play a vital role in determining how readily this compound dissolves, affecting its usability in various chemical applications.

Interesting facts

Interesting Facts About N,4-Dimethyl-N-nitroso-benzenesulfonamide

N,4-dimethyl-N-nitroso-benzenesulfonamide is a fascinating compound that holds significance in various fields of chemical research. Here are some intriguing aspects of this compound:

  • Role in Organic Chemistry: This compound is classified as a nitroso derivative, which suggests it features a nitroso group (\-N=O) attached to a sulfonamide. Such compounds often serve as key intermediates in organic synthesis.
  • Functionality: The presence of both sulfonamide and nitroso groups in the structure provides unique reactivity, making it a useful building block in manufacturing dyes and pharmaceuticals.
  • Application in Research: Compounds similar to N,4-dimethyl-N-nitroso-benzenesulfonamide are frequently studied for their roles in developing potential anti-cancer agents due to their ability to modify biological pathways.
  • Analytical Techniques: This compound can be analyzed using various spectroscopy methods, enabling scientists to study its properties and reactivity in depth. Techniques like NMR (nuclear magnetic resonance) and IR (infrared spectroscopy) are particularly useful.
  • Environmental Considerations: As with many nitroso compounds, there are considerations regarding their stability and environmental impact, which make understanding their behavior in different conditions crucial for those in the field of environmental chemistry.

In summary, N,4-dimethyl-N-nitroso-benzenesulfonamide is not just a compound of interest; it serves as a vital piece in the intricate puzzle of chemical research. As scientists continue to explore its properties and applications, they may uncover even more about its potential benefits and challenges.

Synonyms
80-11-5
Diazald
N-Methyl-N-nitroso-p-toluenesulfonamide
N-Methyl-N-nitrosotoluene-4-sulphonamide
N,4-dimethyl-N-nitrosobenzenesulfonamide
Diazale
Benzenesulfonamide, N,4-dimethyl-N-nitroso-
P-TOLYLSULFONYLMETHYLNITROSAMIDE
Diazalo
p-Tolylsulfonylmethylnitrosamine
p-Toluenesulfonamide, N-methyl-N-nitroso-
Methylnitroso-p-toluenesulfonamide
Toluene-p-sulfonylmethylnitrosamide
N-Nitroso-N-methyl-p-toluenesulfamide
N-Nitroso-N-methyl-4-tolylsulfonamide
p-Tolylsulfonyl-methyl-nitrosamid
N-Methyl-N-nitroso-p-tolylsulfonylamide
NSC 313
HSDB 5234
EINECS 201-252-6
BRN 2214345
AI3-52479
p-Tolylsulfonyl-methyl-nitrosamid [German]
NSC-313
K3089966LA
Diazald(R)-N-methyl-13C
N-Methyl-N-nitroso-4-toluenesulfonamide
N-Methyl-N-nitrosotoluene-4-sulfonamide
N-Nitroso-N-methyl-p-toluenesulfonamide
N-Methyl-N-Nitroso-p-Toluene Sulfonamide
DTXSID8058827
4-11-00-00478 (Beilstein Handbook Reference)
N-nitroso-N-methyl-4-toluenesulfonamide
p-Toluenesulfonyl-N-methyl-N-nitrosamide
P-TOLYLSULFONYLMETHYLNITROSAMIDE [MI]
P-TOLYLSULFONYLMETHYLNITROSAMIDE [HSDB]
METHYL-N-NITROSO-P-TOLUENESULFONAMIDE, N-
WLN: ONN1&SWR D1
N-Methyl-N-nitrosotoluene-4-sulphonamide (NTOLS)
N,4-DIMETHYL-N'-OXOBENZENE-1-SULFONOHYDRAZIDE
Benzenesulfonamide,4-dimethyl-N-nitroso-
DIAZOGEN
60858-95-9
P-TOLYLSULFONYL-METHYL-NITROSAMID (GERMAN)
UNII-K3089966LA
N-Nitroso-p-toluenesulfomethylamide
Diazomethane precursor
N-Methyl-N-(p-tolylsulfonyl)nitrosamide
N-methyl-N-nitroso-p-toluenesulphonamide
N,4-dimethyl-N-nitroso-benzenesulfonamide
Diazald(R), 99%
pTolylsulfonylmethylnitrosamid
pTolylsulfonylmethylnitrosamine
MLS001361349
SCHEMBL105447
Methylnitrosoptoluenesulfonamide
NNitrosoNmethylptoluenesulfamide
NNitrosoNmethyl4tolylsulfonamide
NSC313
Toluenepsulfonylmethylnitrosamide
p-Tolylsulfonylmethylnitrosoamide
CHEMBL1606452
DTXCID8048157
NMethylNnitrosoptoluenesulfonamide
NMethylNnitrosoptolylsulfonylamide
NSC5290
CHEBI:143725
HMS2230C22
HMS3369J17
NSC-5290
pToluenesulfonamide, NmethylNnitroso
MFCD00002050
STL146734
AKOS005720984
n-methyl-n-nitroso-p-toluensulfonamide
AB00201
Benzenesulfonamide, N,4dimethylNnitroso
N-methyl N-nitroso-p-toluenesulfonamide
n-methyl-n-nitrosotoluene-p-sulphonamide
N-methyl-N-nitroso-p-toluenesul-fonamide
NCGC00247025-01
AS-64766
SMR000875348
N-Methyl-N-nitroso, p-toluene sulfonamide
NS00000641
T0323
N,4-Dimethyl-N'-oxobenzenesulfonohydrazide #
A839839
BENZENESULFONAMIDE, N-4-DIMETHYL-N-NITROSO-
Q20650189
N-Methyl-N-nitroso-p-toluenesulfonamide, purum, >=98.0% (HPLC)
N-Methyl-N-(p-tolylsulfonyl)nitrosamide; p-Tolylsulfomethylnitrosamide
201-252-6