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N,N-Dimethylbenzenesulfonamide

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Identification
Molecular formula
C8H11NO2S
CAS number
6398-29-8
IUPAC name
N,4-dimethylbenzenesulfonamide
State
State

At room temperature, N,4-Dimethylbenzenesulfonamide is typically a solid. The solid state makes it suitable for various applications in organic synthesis and chemical manufacturing processes.

Melting point (Celsius)
123.50
Melting point (Kelvin)
396.65
Boiling point (Celsius)
346.30
Boiling point (Kelvin)
619.45
General information
Molecular weight
185.26g/mol
Molar mass
185.2570g/mol
Density
1.2176g/cm3
Appearence

N,4-Dimethylbenzenesulfonamide usually appears as a white to off-white crystalline solid. Its solid form is often quite pure, depending on its storage and handling conditions, and it may sometimes present as colorless crystals.

Comment on solubility

Solubility of N,4-dimethylbenzenesulfonamide

N,4-dimethylbenzenesulfonamide, a sulfonamide compound, exhibits intriguing solubility characteristics that can be attributed to its molecular structure. This compound provides a fascinating case study for solubility due to the following factors:

  • Polar Functional Groups: The presence of the sulfonamide group (-SO2NH2) enhances its polar character, which generally improves solubility in polar solvents, particularly water.
  • Hydrophobic Characteristics: The dimethyl groups can add some hydrophobicity, which may limit solubility in water but enhance compatibility with organic solvents.
  • Hydrogen Bonding: The ability of the amine to participate in hydrogen bonding can significantly affect solubility behavior, facilitating interactions with various solvent molecules.

Generally, compounds like N,4-dimethylbenzenesulfonamide tend to exhibit moderate solubility in water. As a result, one might say: “It is the interplay of hydrophilic and hydrophobic interactions that dictates the solubility profile of sulfonamides.” This makes it crucial for chemists to consider both the functional groups present and the overall molecular architecture to predict solubility outcomes accurately.

In summary, the solubility of N,4-dimethylbenzenesulfonamide is influenced by its unique combination of polar and non-polar characteristics, making it a versatile compound in both aqueous and organic environments.

Interesting facts

Interesting Facts About N,4-Dimethylbenzenesulfonamide

N,4-dimethylbenzenesulfonamide, a notable organic compound, belongs to the family of sulfonamides, which are renowned for their medicinal properties. Here's what makes this compound intriguing:

  • Medicinal Applications: Sulfonamides, in general, have played a pivotal role in the development of antibiotics. N,4-dimethylbenzenesulfonamide is often explored for its potential therapeutic uses, particularly in the treatment of bacterial infections.
  • Diverse Functional Groups: The presence of both a sulfonamide group and dimethyl substituents enhances the compound's reactivity. This complexity allows for a variety of chemical reactions that can lead to the synthesis of potentially useful derivatives.
  • Biological Activity: Some studies indicate that compounds like N,4-dimethylbenzenesulfonamide exhibit anti-inflammatory properties. This makes them interesting candidates for further research in pharmacology.
  • Research Potential: The chemical structure of N,4-dimethylbenzenesulfonamide provides a platform for structural modifications. Chemists can explore its interactions with various biological targets, potentially revealing new insights into drug design.
  • Environmental Impact: The use and breakdown of sulfonamide drugs in the environment can lead to concerns regarding microbial resistance. Understanding the environmental fate of compounds like N,4-dimethylbenzenesulfonamide is crucial in addressing these issues.

In summary, N,4-dimethylbenzenesulfonamide not only serves as an interesting subject of study in organic chemistry but also holds potential implications for medicinal research and environmental science. As we delve deeper into its properties and applications, we may uncover exciting discoveries that contribute to the fields of chemistry and pharmaceuticals.

Synonyms
N-Methyl-p-toluenesulfonamide
640-61-9
N,4-DIMETHYLBENZENESULFONAMIDE
Benzenesulfonamide, N,4-dimethyl-
NSC 2223
N-Methyl-para-toluenesulfonamide
EINECS 211-366-8
NSC 36991
N-Methyl-p-toluolsulfonamide
AI3-00115
DTXSID5060938
pTolueneNmethylsulfonamide
NMethyltoluene4sulphonamide
(pTolylsulfonyl)methylamine
pToluenesulfonamide, Nmethyl
N,4Dimethylbenzenesulfonamide
Benzenesulfonamide, N,4dimethyl
DTXCID3044174
pToluenesulfonamide, Nmethyl (8CI)
gwlogzrvyxahre-uhfffaoysa-n
inchi=1/c8h11no2s/c1-7-3-5-8(6-4-7)12(10,11)9-2/h3-6,9h,1-2h
p-Toluenesulfonamide, N-methyl-
(p-Tolylsulfonyl)methylamine
p-Toluene-N-methylsulfonamide
N,4-dimethylbenzene-1-sulfonamide
MFCD00008285
MLS000530144
SMR000135122
Benzenesulfonamide,4-dimethyl-
N-Methyltoluene-4-sulphonamide
N,4-Dimethyl-benzenesulfonamide
Opera_ID_815
Enamine_005786
Cambridge id 5110919
SCHEMBL30960
4,N-Dimethylbenzenesulphonamide
N,4-dimethyl benzenesulfonamide
N,4-dimethylbenzenesulfon-amide
SCHEMBL7049553
CHEMBL1565275
NSC2223
HMS1410G22
HMS2358H22
N-methyl-4-methylbenzenesulfonamide
ALBB-022231
NSC-2223
NSC36991
N-Methyl-p-toluenesulfonamide, 98%
N-Methyl-4-methylbenzene sulfonamide
NSC-36991
STK803573
AKOS000119951
AC-4395
BS-4008
CCG-356432
CS-W016946
IDI1_008021
NCGC00170650-01
SY004935
DB-054602
M1717
NS00022612
EN300-15849
PK04_094315
BRD-K39147129-001-01-3
Z45527660
F0808-1503