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Thiotepa

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Identification
Molecular formula
C6H12Cl2HN3O2P
CAS number
52-24-4
IUPAC name
N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-dithiaphospholan-2-amine
State
State

At room temperature, Thiotepa is in a solid state. It is commonly handled as a powder in medical and laboratory settings.

Melting point (Celsius)
52.00
Melting point (Kelvin)
325.15
Boiling point (Celsius)
180.00
Boiling point (Kelvin)
453.15
General information
Molecular weight
189.14g/mol
Molar mass
189.1420g/mol
Density
1.2880g/cm3
Appearence

Thiotepa typically appears as a white crystalline powder. It is known for its stability and storage conditions but needs to be handled carefully due to its potency and use as a chemotherapeutic agent.

Comment on solubility

Solubility of N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-dithiaphospholan-2-amine

The solubility characteristics of N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-dithiaphospholan-2-amine can be subject to various influencing factors. This compound, like many organophosphorus compounds, displays unique solubility behaviors depending on its chemical structure and functional groups. Below are some noteworthy points regarding its solubility:

  • Polar Nature: Due to the presence of polar functional groups such as -NH and -C=O, the compound exhibits some degree of solubility in polar solvents, particularly in aqueous environments.
  • Solvent Compatibility: N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-dithiaphospholan-2-amine may dissolve to a lesser extent in organic solvents like ethanol or dimethyl sulfoxide (DMSO) due to limited interaction with these solvents.
  • Temperature Influence: As with many compounds, increased temperature can enhance solubility, leading to an increased molecular motion that favors dissolution.
  • pH Sensitivity: The solubility can also be pH-dependent, where changes in pH can protonate or deprotonate functional groups, altering their solubility profile.

In conclusion, the solubility of N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-dithiaphospholan-2-amine is a complex interplay of its chemical structure, solvent choice, and environmental conditions. Understanding these factors is crucial for applications in chemical synthesis and pharmaceutical development.

Interesting facts

Interesting Facts about N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-dithiaphospholan-2-amine

The compound N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-dithiaphospholan-2-amine is a fascinating example of a phosphorus-containing compound with unique structural and chemical characteristics. Here are some engaging aspects of this compound:

  • Phosphorus Chemistry: This compound belongs to the class of organophosphorus compounds, which are known for their versatility and application in various fields including agriculture, medicine, and materials science.
  • Drug Development: The presence of the chloroethyl moieties suggests potential applications in medicinal chemistry, particularly in the design of antitumor agents.
  • Ring Structure: The incorporation of a dithiaphospholane ring signifies a rich chemistry, often leading to interesting reactivity and stability profiles that can be exploited in synthetic chemistry.
  • Functionalization: The ability to modify dithiaphospholanes allows chemists to create derivatives that can impart various functionalities, making them useful as building blocks in organic synthesis.
  • Research Potential: As a lesser-known compound, it offers a wealth of opportunities for research, particularly in studying its reactivity and potential applications in catalytic processes.
  • Environmental Considerations: As with many organophosphorus compounds, careful studies of toxicity and environmental impact are essential to understand their safety and sustainability in various applications.

In conclusion, N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-dithiaphospholan-2-amine embodies the intriguing interplay between structure and function, inviting further exploration in the fields of organic and inorganic chemistry.

Synonyms
B 832
BRN 2453062
1,3,2-DITHIAPHOSPHOLANE, 2-(BIS(2-CHLOROETHYL)AMINO)-, 2-OXIDE
DTXSID40175064
2091-06-7
2-(Bis(2-chloroethyl)amino)-1,3,2-dithiaphospholane 2-oxide
DTXCID3097555