Cyclophosphamide | Solubility of Things

Identification

Molecular formula

C₇H₁₅Cl₂N₂O₂P

CAS number

50-18-0

IUPAC name

N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine

State

At room temperature, Cyclophosphamide is in a solid state, appearing as a crystalline powder.

Melting point (Celsius)

50.00

Melting point (Kelvin)

323.15

Boiling point (Celsius)

115.00

Boiling point (Kelvin)

388.15

General information

Molecular weight

261.09g/mol

Molar mass

261.0930g/mol

Density

1.3400g/cm³

Appearence

Cyclophosphamide appears as a white crystalline powder. It is odorless and dissolves in water, ethanol, and chloroform.

Comment on solubility

Solubility of N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine

The solubility of the compound N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine (C₇H₁₅Cl₂N₂O₂P) can be described as follows:

Polarity: Due to the presence of multiple functional groups, including chlorine atoms and a phosphinane structure, the compound exhibits moderate polarity.
Aqueous Solubility: Generally, compounds containing halogens may have varying solubility in water, but typically this compound would show limited solubility in aqueous solutions.
Organic Solvents: It is likely to be more soluble in organic solvents such as ethanol or acetone, which can stabilize the molecule's structure.
Factors Affecting Solubility: Factors such as temperature and pH can play a significant role in solubility changes, making it crucial to test these conditions experimentally.

In summary, while this compound may be sparingly soluble in water, its solubility could increase in organic solvents. Understand the specific solvent interactions for practical applications or further studies.

Interesting facts

Interesting Facts about N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine

N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine is a fascinating compound that belongs to the class of phosphoramide derivatives. This compound serves as an excellent example of how modifications at the molecular level can lead to significant changes in biological activity and applications.

Key Characteristics and Applications

Pharmacological Potential: The compound exhibits potential as a chemotherapeutic agent. Its unique structure allows it to interact with biological molecules, which may lead to advancements in cancer treatments.
Mechanism of Action: It possesses a phosphorous atom bonded to both chlorine and amine groups, which can influence its reactivity and interaction with nucleophiles.
Research Interests: The compound is of interest in medicinal chemistry due to its ability to form reactive intermediates that can lead to cellular damage in cancerous cells.

One of the most intriguing aspects of N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine is its application in developing innovative therapies for diseases resistant to traditional treatments. According to researchers, "the unique phosphazene structure enhances reactivity with biological targets, offering new pathways for selective toxicity against tumor cells."

Considerations in Research

Synthetic Challenges: The synthesis of N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine can be complex, requiring careful control of reaction conditions to achieve the desired product.
Toxicity Studies: Due to its chlorinated moieties, assessing the toxicity and environmental impact of this compound is critical to ensure safe applications in medicinal settings.

In conclusion, N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine exemplifies how sophisticated chemistry can drive innovation in medicine. Its study continues to inspire chemists and pharmacologists alike as they unravel its full potential.

Synonyms

cyclophosphamide

50-18-0

Cytoxan

Cyclophosphamid

Cyclophosphane

Endoxan

Cytophosphan

Procytox

Sendoxan

Clafen

Cyclophosphan

Cyclostin

Cyclophosphamidum

Cytophosphane

Endoxanal

Neosar

Claphene

Endoxana

Genoxal

Endoxan-Asta

Endoxan R

Zyklophosphamid

Mitoxan

Cyclophosphoramide

Cyklofosfamid

Endoxane

(RS)-Cyclophosphamide

Cyclophosphamide anhydrous

Ciclofosfamida

Cyclophosphanum

Enduxan

Semdoxan

Senduxan

(+-)-Cyclophosphamide

Ciclophosphamide

ASTA

Lyophilized Cytoxan

D,L-Cyclophosphamide

Rcra waste number U058

Asta B 518

(-)-Cyclophosphamide

Cycloblastin

NSC-26271

2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide

Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester

CB 4564

Cyclophosphamide (anhydrous)

NCI-C04900

ASTA B518

SK 20501

NSC 26271

CHEBI:4027

B 518

Occupation, cyclophosphamide exposure

CCRIS 188

N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide

4-Hydroxy-cyclophosphan-mamophosphatide

HSDB 3047

Anhydrous cyclophosphamide

EINECS 200-015-4

Ciclofosfamide

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

UNII-6UXW23996M

BRN 0011744

Cyclophosphamide-d4

AI3-26198

6UXW23996M

Cyclophosphamide (INN)

1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin

2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-,2-oxide

NSC26271

Cytoxan (TN)

2-(Bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorine 2-oxide

N,N-Bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide

N,N-Di(2-chloroethyl)-N,O-propylene-phosphoric acid ester diamide

50-18-0 (anhydrous)

2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, intramol. ester

DTXSID5020364

CYCLOPHOSPHAMIDE LYOPHILIZED

CYCLOPHOSPHAMIDE, ANHYDROUS

N,N-Bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide

2-(Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazophosphorine 2-oxide

N,N-Bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide

Cyklofosfamid [Czech]

N,N-bis(2-chloroethyl)-2-oxo-1,3,2$l^{5}-oxazaphosphinan-2-amine

N,N-Bis-(beta-chloraethyl)-N',O-propylen-phosphorsaeure-ester-diamid

Ciclophosphamide [INN]

2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

2H-1,3,2-Oxazaphosphorine, 2-(bis(2-chloroethyl)amino)tetrahydro-, 2-oxide

Zyklophosphamid [German]

NSC-756711

Ciclophosphamide hydrat

Cytoxan (Lyophilized)

CYCLOPHOSPHAMIDE [INN]

Ciclofosfamida [INN-Spanish]

Cyclophosphamidum [INN-Latin]

UNII-8N3DW7272P

CYCLOPHOSPHAMIDE (IARC)

CCRIS 7469

CYCLOPHOSPHAMIDE (USP-RS)

Cyclophosphamide (anhydrous form)

Cyclophosphamide (TN)

CYCLOPHOSPHAMIDE (EP MONOGRAPH)

CYCLOPHOSPHAMIDE (USP MONOGRAPH)

SR-01000075737

NCGC00015209-05

RCRA waste no. U058

Cyclophosphamide [USP:INN]

Cycloblastine

Cyclophospham

Cyclostine

Fosfaseron

Syklofosfamid

Carloxan

Cicloxal

Genuxal

Ledoxina

2-(Bis(2-chloroethyl)amino)-2H-1,2-oxazaphosphorine 2-oxide

2-[Bis(2-chloroethyl)amino]-2H-1,2-oxazaphosphorine 2-oxide

Cyclophosphamide?

2-(Bis(2-chloroethylamino))-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

(Bis(chloro-2-ethyl)amino)-2-tetrahydro-3,5,6-oxazaphosphorine-1,3,2-oxide-2 hydrate

[Bis(chloro-2-ethyl)amino]-2-tetrahydro-3,5,6-oxazaphosphorine-1,3,2-oxide-2 hydrate

2-(BIS(2-CHLOROETHYL)AMINO)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE

CYCLO-cell

N,N-Bis(beta-cloraethyl) N'-O-propylenphosphorildiamid monohydratum

bis(2-Chloroethyl)phosphamide cyclic propanolamide ester

CB-4564

Spectrum_000858

CHEMBL88

Spectrum2_001146

Spectrum3_000370

Spectrum4_000304

Spectrum5_000795

Lopac-C-0768

Epitope ID:131782

C 0768

N,N-Bis-(beta-chloraethyl)-N',O-propylen-phosphorsaeure-ester-diamid [German]

SCHEMBL4346

(.+/-.)-Cyclophosphamide

Lopac0_000238

BSPBio_002099

KBioGR_000888

KBioSS_001338

DivK1c_000246

DTXCID70364

SPBio_001071

CYCLOPHOSPHAMIDE [HSDB]

GTPL7154

SCHEMBL4345553

2-H-1,3,2-Oxazaphosphorinane

SCHEMBL10262910

CMSMOCZEIVJLDB-UHFFFAOYSA-

KBio1_000246

KBio2_001338

KBio2_003906

KBio2_006474

KBio3_001319

CYCLOPHOSPAMIDE MONOHYDRATE

CYCLOPHOSPHAMIDE [WHO-DD]

L01AA01

WLN: T6MPOTJ BO BN2G2G

NINDS_000246

2-(bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide

HMS2090A12

HMS3260P17

HMS3715J05

Pharmakon1600-01500213

BCP02139

Tox21_500238

BDBM50237604

N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine

NSC273033

NSC273034

NSC756711

STK177249

AKOS005410738

tetrahydro-N,N-bis(2-chloroethyl)-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

CS-1425

CYCLOPHOSPHAMIDE ANHYDROUS [MI]

DB00531

LP00238

NSC-273033

NSC-273034

SDCCGSBI-0050226.P004

IDI1_000246

N,3,2-oxazaphosphorin-2-amine-2-oxide

N,O-propylen-phosphorsaeure-ester-diamid

NCGC00015209-01

NCGC00015209-02

NCGC00015209-03

NCGC00015209-04

NCGC00015209-06

NCGC00015209-07

NCGC00015209-08

NCGC00015209-09

NCGC00015209-12

NCGC00015209-28

NCGC00091741-02

NCGC00091741-03

NCGC00260923-01

AS-73255

BP-25411

HY-17420

NCI60_002097

N,O-propylenephosphoric acid ester diamide

SBI-0050226.P003

DB-082057

N,O-propylene-phosphoric acid ester diamide

WR-138719

C2236

EU-0100238

N,O-trimethylenephosphoric acid ester diamide

NS00000339

EN300-74526

A12571

C07888

D07760

AB00053446-09

AB00053446-11

AB00053446-12

AB00053446_13

AB00053446_14

AB00053446_15

Q408524

W-60377

N,O-propylenephosphoric acid ester amide monohydrate

SR-01000075737-1

SR-01000075737-6

BRD-A09722536-002-02-4

BRD-A09722536-002-17-2

BRD-A09722536-002-18-0

BRD-A09722536-002-19-8

Z276509078

2-(bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane2-oxide

Bis(2-chloroethyl)phosphoramide-cyclic propanolamide ester

2-[bis(2-chloroethyl)amino]-1,3,2??-oxazaphosphinan-2-one

1-BIS(2-CHLOROETHYL)AMINO-1-OXO-2-AZA-5-OXAPHOSPHORIDINE

2-[bis(2-chloroethyl)amino]-1,3,2$l^{5}-oxazaphosphinan-2-one

2-[bis(2-chloroethyl)amino]-1,3,2lambda5-oxazaphosphinan-2-one

N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide #

2-[Bis(2-chloroethyl)amino]tetrahydro-1,3,2-oxazaphosphorin-2-oxide

2H-1,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide

2H-1,3,2-Oxazaphosphorine, 2-(bis(2-chloroethyl)amino)tetrahydro-,2-oxide

N,N-Bis(.beta.-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide

N,N-Bis-(.beta.-chloraethyl)-N',O-propylen-phosphorsaeure-ester-diamid

N,N-DI(2-CHLOROETHYL)-N,O-PROPYLENE PHOSPHORIC ACID ESTER DIAMIDE

(+/-)-2-(BIS(2-CHLOROETHYL)AMINO)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE

2-(DI(2-CHLOROETHYLAMINO))-1-OXA-3-AZA-2-PHOSPHACYCLOHEXANE 2-OXIDE

2-Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

2H-1,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide

2H-1,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, (+)-

2H-1,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, (-)-

2H-1,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate

2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide

N,N-bis(2-chloroethyl)-2-oxo-1-oxa-3-aza-2$l^{5}-phosphacyclohexan-2-amine

N,N-BIS(2-CHLOROETHYL)-N'-(3-HYDROXYPROPYL)PHOSPHORODIAMIDIC ACID INTRAMOL.

N,N-BIS(BETA-CHLOROETHYL)N',O-TRIMETHYLENEPHOSPHORIC ACID ESTER DIAMIDE

Phosphorodiamidic acid,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, intramol. ester

200-015-4

InChI=1/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12)