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Chlormethine

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Identification
Molecular formula
C7H11Cl2NO
CAS number
51-75-2
IUPAC name
N,N-bis(2-chloroethyl)-3-(2-furyl)prop-2-enamide
State
State

Chlormethine is typically found as a liquid at room temperature. However, it can also be encountered in a reconstituted form for medical applications, such as a topical ointment used in chemotherapy.

Melting point (Celsius)
-40.00
Melting point (Kelvin)
233.15
Boiling point (Celsius)
191.00
Boiling point (Kelvin)
464.15
General information
Molecular weight
204.08g/mol
Molar mass
204.5480g/mol
Density
1.4540g/cm3
Appearence

Chlormethine, also known as mechlorethamine, typically appears as a colorless to pale yellow, oily liquid. It is highly volatile and has an odor similar to that of mustard or fish. Due to its vesicant properties, it can cause severe blistering upon skin contact.

Comment on solubility

Solubility of N,N-bis(2-chloroethyl)-3-(2-furyl)prop-2-enamide

N,N-bis(2-chloroethyl)-3-(2-furyl)prop-2-enamide is a compound with unique solubility characteristics that are influenced by both its structural components and functional groups.

In general, the solubility of this compound can be described as follows:

  • Polarity: The presence of the chloroethyl groups adds to the polar nature of the compound, potentially increasing its solubility in polar solvents.
  • Hydrophobic Character: The furyl ring contributes a hydrophobic aspect to the molecule, which may limit solubility in water, but it could enhance solubility in organic solvents.
  • Solvent Compatibility: Common solvents such as ethanol, methanol, or dimethyl sulfoxide (DMSO) might dissolve this compound effectively due to their polar characteristics.

As solubility can be heavily affected by factors like temperature and pH, it is essential to consider the specific conditions under which the solubility is being evaluated. Adjustments in these parameters may lead to significant variations in solubility profiles.

In summary, while N,N-bis(2-chloroethyl)-3-(2-furyl)prop-2-enamide can exhibit solubility in certain solvents, its overall behavior in different environments merits careful assessment. Test conditions and solvent choice are thus crucial for determining its practical applications.

Interesting facts

Interesting Facts about N,N-bis(2-chloroethyl)-3-(2-furyl)prop-2-enamide

N,N-bis(2-chloroethyl)-3-(2-furyl)prop-2-enamide is a compound with a fascinating role in chemistry, particularly in medicinal and agricultural applications. Here are some captivating aspects:

  • Versatile Applications: This compound has garnered attention for its potential use in the field of chemotherapy. Its structure allows it to interact with biological systems effectively, making it a candidate for developing anticancer agents.
  • Furan Ring Chemistry: The presence of the furan moiety in its structure contributes to its intriguing reactivity. Furan is known for its ability to participate in various chemical reactions, including nucleophilic additions and cycloadditions.
  • Chloroethyl Groups: The 2-chloroethyl groups play a crucial role in increasing the compound's reactivity. These moieties can readily undergo nucleophilic substitution reactions, making the compound useful for further chemical modifications.
  • Dual Functionality: This compound showcases dual functionality thanks to its amide and alkene parts. This allows it to participate in a variety of reactions, which can potentially lead to novel synthetic pathways in organic chemistry.

As researchers continue to explore the properties of N,N-bis(2-chloroethyl)-3-(2-furyl)prop-2-enamide, it remains a subject of interest due to its unique structural features and the opportunities it presents in both synthesis and pharmacology. Its potency and versatility emphasize the importance of understanding such compounds in the quest for new therapeutic agents.