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Chlornapazine

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Identification
Molecular formula
C11H15Cl2NO
CAS number
90-75-5
IUPAC name
N,N-bis(2-chloroethyl)-4-methoxy-aniline
State
State

At room temperature, Chlornapazine is a liquid. It is typically stored in closed containers to prevent exposure to air and moisture.

Melting point (Celsius)
-20.00
Melting point (Kelvin)
253.15
Boiling point (Celsius)
315.80
Boiling point (Kelvin)
588.95
General information
Molecular weight
250.15g/mol
Molar mass
250.1510g/mol
Density
1.2181g/cm3
Appearence

Chlornapazine typically appears as a colorless to pale yellow liquid. The compound is often handled in solution form due to its application and potential hazards.

Comment on solubility

Solubility of N,N-bis(2-chloroethyl)-4-methoxy-aniline

N,N-bis(2-chloroethyl)-4-methoxy-aniline is a compound with intriguing solubility properties that can significantly impact its practical applications. Understanding its solubility is crucial for various fields, including pharmaceuticals and materials science.

General Solubility Characteristics:

  • The compound is expected to exhibit moderate solubility in organic solvents due to the presence of both polar (amino) and nonpolar (methoxy and chloroethyl) groups.
  • It may show limited solubility in water, primarily because of the hydrophobic nature of the chloroethyl groups.
  • Solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO) could enhance its solubility due to their polar characteristics.

Factors Influencing Solubility:

  • Temperature: Generally, increasing temperature can enhance solubility in a given solvent.
  • pH: The solubility may also be affected by the pH of the solution, particularly due to the basic nature of the amino group.
  • Presence of Solubilizing Agents: Additives such as surfactants can also promote the solubility of this compound.

In conclusion, the solubility of N,N-bis(2-chloroethyl)-4-methoxy-aniline is a complex interplay of its chemical structure and the nature of the solvents involved. Further studies could provide more detailed insights into optimizing its solubility for specific applications.

Interesting facts

Interesting Facts about N,N-bis(2-chloroethyl)-4-methoxy-aniline

N,N-bis(2-chloroethyl)-4-methoxy-aniline, often referred to in scientific literature, is a fascinating compound with notable applications and properties. Below are some interesting aspects to consider:

  • Biological Significance: This compound exhibits significant medicinal properties, particularly in the realm of anti-cancer research. Its ability to act as an alkylating agent makes it a candidate for targeted therapies against certain types of tumors.
  • Chemical Structure: The structure of N,N-bis(2-chloroethyl)-4-methoxy-aniline is characterized by its amino group, which lends it unique reactivity compared to other similar compounds. The presence of the methoxy group enhances its lipophilicity, influencing how it interacts with biological systems.
  • Historical Context: Compounds of this type have been synthesized and studied since the late 20th century, contributing significantly to the development of chemotherapeutic agents. Researchers have sought to improve their efficacy and reduce side effects in drug formulations.
  • Research Potential: As a subject of ongoing studies, this compound presents numerous opportunities for chemists and pharmacologists. Continued research may unveil new pathways for improved drug delivery and reduced resistance in cancer therapies.
  • Safety Considerations: While N,N-bis(2-chloroethyl)-4-methoxy-aniline shows promise in therapeutic applications, handling this compound requires caution due to its potential toxicity and adverse effects. Proper laboratory practices and safety protocols are essential.

In summary, N,N-bis(2-chloroethyl)-4-methoxy-aniline is not just another chemical; it holds the key to exciting advancements in medicinal chemistry and cancer therapy. As we continue to explore its properties, we may uncover even more potential applications that could benefit healthcare.

Synonyms
N,N-Bis(2-chloroethyl)-4-methoxyaniline
1448-52-8
p-ANISIDINE, N,N-BIS(2-CHLOROETHYL)-
N,N-Bis(2-chloroethyl)-4-methoxybenzenamine
NIOSH/IA1500000
NSC 31577
C.B. 1045
p-Bis(beta-chloroaethyl)amino-phenylmethoxyl
IA15000000
Diethylamine, 2,2'-dichloro-N-(p-methoxyphenyl)-
p-Bis(beta-chloroaethyl)amino-phenylmethoxyl [German]
Benzenamine, N,N-bis(2-chloroethyl)-4-methoxy-
N,N-Bis(2-chloroethyl)-p-anisidine
N,N-Di-(2-chloroethyl)-p-anisidine
BRN 2940120
N,N-Bis(2-chloroethyl)-p-methoxyaniline
para-N,N-Di(2-chloroethyl)methoxyaniline
NSC31577
CHEMBL17360
SCHEMBL659196
DTXSID80162812
XEXFMTLVGVELAA-UHFFFAOYSA-N
p-Methoxy-N,N-dichloroethylaniline
p-Anisidine,N-bis(2-chloroethyl)-
NSC-31577
p-N,N-Di(2-chloroethyl)methoxyaniline
DA-10215
N,N-bis-(2-chloroethyl)-p-methoxy-aniline
Benzenamine,N-bis(2-chloroethyl)-4-methoxy-