Skip to main content

Fluconazole

ADVERTISEMENT
Identification
Molecular formula
C13H12F2N6O
CAS number
86386-73-4
IUPAC name
N,N-bis(2,2,2-trifluoroethyl)nitrous amide
State
State

At room temperature, fluconazole is in a solid state, specifically a crystalline powder.

Melting point (Celsius)
138.00
Melting point (Kelvin)
411.15
Boiling point (Celsius)
186.00
Boiling point (Kelvin)
459.15
General information
Molecular weight
306.28g/mol
Molar mass
306.2810g/mol
Density
1.4680g/cm3
Appearence

Fluconazole is a colorless to white crystalline solid. It is odorless and appears as a crystalline powder.

Comment on solubility

Solubility of N,N-bis(2,2,2-trifluoroethyl)nitrous amide

N,N-bis(2,2,2-trifluoroethyl)nitrous amide is a compound notable for its unique solubility characteristics. Understanding its solubility can provide insights into its behavior in various systems:

  • Insolubility in Water: This compound is generally considered to be insoluble in water due to its large hydrophobic trifluoroethyl groups.
  • Solubility in Organic Solvents: It exhibits good solubility in a variety of organic solvents. Common examples include:
    • Dichloromethane
    • Acetone
    • Hexane
  • Influence of Temperature: Like many chemical compounds, its solubility can be influenced by temperature. Increased temperatures typically enhance the solubility in organic solvents.
  • Applications in Synthesis: Its solubility in organic solvents allows it to be effectively employed in various reactions, making it a valuable compound in synthetic chemistry.

In summary, while N,N-bis(2,2,2-trifluoroethyl)nitrous amide shows limited solubility in polar solvents like water, its compatibility with non-polar and moderately polar organic solvents reflects its potential utility in various chemical applications. Understanding the solubility profile can greatly aid in the selection of appropriate solvents for reactions involving this compound.

Interesting facts

Interesting Facts about N,N-bis(2,2,2-trifluoroethyl)nitrous amide

N,N-bis(2,2,2-trifluoroethyl)nitrous amide is a fascinating compound, notable for its unique structure and applications. Here are some highlights that make this compound particularly interesting:

  • Fluorinated Compound: The presence of trifluoroethyl groups in its structure imparts special properties, such as increased thermal stability and low surface energy, making it suitable for various chemical applications.
  • Applications: This compound is often utilized in the field of organic synthesis. Its reactivity makes it a potential candidate for:
    • Fluorination reactions
    • Agrochemical production
    • Pharmaceutical intermediates
  • Environmental Impact: Fluorinated compounds have garnered attention due to their environmental persistence. Understanding their behavior and fate in ecosystems is crucial, as it raises questions about sustainability and ecological safety.
  • Research Interest: Chemists are increasingly investigating the properties of compounds like N,N-bis(2,2,2-trifluoroethyl)nitrous amide, with a focus on finding greener alternatives and minimizing harmful effects associated with traditional compounds.
  • Quotes from Researchers: As one researcher noted, "Fluorinated compounds open doors to innovative synthetic pathways, but we must tread carefully with their environmental impact." This reflects the dual nature of their utility and responsibility in scientific practices.

In conclusion, N,N-bis(2,2,2-trifluoroethyl)nitrous amide represents a blend of utility and caution in modern chemistry. Its intriguing properties and wide-ranging applications provide exciting opportunities for both research and industry.

Synonyms
2,2,2-trifluoro-N-nitroso-N-(2,2,2-trifluoroethyl)ethanamine
NITROSOBIS(2,2,2-TRIFLUOROETHYL)AMINE
870-772-9
N-Nitrosobis(2,2,2-trifluoroethyl)amine
625-89-8
N,N-bis(2,2,2-trifluoroethyl)nitrous amide
N-Nitrosobis(2,2,2-trifluoroethyl) amine
6-F-Den
Hexafluorodiethylnitrosamine
BRN 1790462
N-Nitroso-bis(2,2,2-trifluoroethyl)amine
N-Nitroso-2,2,2,2',2',2'-hexafluorodiethylamine
NDEA-F6
QG3BFB8FC9
DTXSID7021023
YUEXLPFBTMPXCY-UHFFFAOYSA-N
DIETHYLAMINE, N-NITROSO-2,2,2,2',2',2'-HEXAFLUORO-
Ethanamine, 2,2,2-trifluoro-N-nitroso-N-(2,2,2-trifluoroethyl)-
N-nitroso-bis-(2,2,2-trifluoroethyl)amine
Nitrosobis(2,2,2-trifluoroethyl)amine, N-
G83828
EN300-24209973