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N,N'-bis(4-ethoxyphenyl)acetamidine hydrochloride

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Identification
Molecular formula
C18H24ClN2O2
CAS number
38444-90-5
IUPAC name
N,N'-bis(4-ethoxyphenyl)acetamidine;hydrochloride
State
State

At room temperature, N,N'-bis(4-ethoxyphenyl)acetamidine hydrochloride is in a solid state. It remains stable under normal conditions of temperature and pressure.

Melting point (Celsius)
162.00
Melting point (Kelvin)
435.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
342.87g/mol
Molar mass
342.8700g/mol
Density
1.1580g/cm3
Appearence

The compound is typically a white to off-white crystalline powder. Its solid form may also appear as irregularly shaped crystals or a fine powder.

Comment on solubility

Solubility of N,N'-bis(4-ethoxyphenyl)acetamidine;hydrochloride

The compound N,N'-bis(4-ethoxyphenyl)acetamidine;hydrochloride exhibits intriguing solubility characteristics, which can greatly influence its applications in various chemical and pharmaceutical processes. Understanding its solubility behavior is essential for optimizing its use. Here are some key points regarding its solubility:

  • Water Solubility: As a hydrochloride salt, N,N'-bis(4-ethoxyphenyl)acetamidine generally displays enhanced solubility in water compared to its non-salt form, making it more accessible for aqueous solutions.
  • Solvent Dependence: The solubility can vary significantly based on the solvent used. It often demonstrates better solubility in polar solvents due to its ionic nature, while solubility in non-polar solvents is expected to be limited.
  • pH Influence: The solubility of the compound can be affected by the pH of the solution. Typically, acids increase solubility for basic compounds, leading to potential variations in solubility under different conditions.
  • Temperature Effects: An increase in temperature generally enhances solubility; therefore, it is advisable to conduct solubility tests at various temperatures to determine optimal conditions for dissolution.

In summary, the solubility of N,N'-bis(4-ethoxyphenyl)acetamidine;hydrochloride is multifaceted and influenced by several factors, including solvent type, pH, and temperature. Understanding these variables is crucial for effectively utilizing this compound in research and application.

Interesting facts

Interesting Facts about N,N'-bis(4-ethoxyphenyl)acetamidine;hydrochloride

N,N'-bis(4-ethoxyphenyl)acetamidine;hydrochloride is a fascinating compound with unique properties and potential applications. Here are some intriguing aspects to consider:

  • Structure and Functionality: This compound features a distinctive structural configuration that incorporates ethoxy groups attached to phenyl rings, making it interesting from both a structural and functional standpoint.
  • Pharmacological Potential: Research suggests that derivatives of acetamidine compounds may exhibit various biological activities. Their potential as pharmaceuticals, particularly in the field of anti-cancer or anti-inflammatory therapies, is an area of ongoing investigation.
  • Synthetic Pathways: The synthesis of this compound can be accomplished through several synthetic routes, often involving the reaction of aromatic amines with acetamidine derivatives, showcasing the versatility of organic synthesis techniques.
  • Applications in Research: Due to its unique chemical properties, the compound could serve as an important intermediate in the synthesis of more complex molecules or for the development of novel therapeutic agents in medicinal chemistry.
  • Interdisciplinary Significance: The study of such compounds highlights the intersection between organic chemistry, pharmacology, and materials science, offering exciting opportunities for interdisciplinary collaboration and innovation.

As scientists continue to explore the potential of N,N'-bis(4-ethoxyphenyl)acetamidine;hydrochloride, its role in advancing chemical research and contributing to pharmaceutical development may yield significant breakthroughs in the coming years.

Synonyms
Phenacaine hydrochloride
Phenacaine hydrochloride anhydrous
NSC 9293
EINECS 210-662-4
UNII-2B61HM98KO
N,N'-Bis(p-ethoxyphenyl)acetamidine hydrochloride
2B61HM98KO
DTXSID0048769
Acetamidine, N,N'-bis(p-ethoxyphenyl)-, monohydrochloride
DTXCID7028695
ACETAMIDINE, N,N'-BIS(p-ETHOXYPHENYL)-, HYDROCHLORIDE
Ethanimidamide, N,N'-bis(4-ethoxyphenyl)-, monohydrochloride
PHENACAINE HYDROCHLORIDE [MI]
N,N'-BIS(P-ETHOXYPHENYL)ACETAMIDINE MONOHYDROCHLORIDE
N,N'-BIS(4-ETHOXYPHENYL)ETHANIMIDAMIDE MONOHYDROCHLORIDE
ETHANIMIDAMIDE, N,N'-BIS(4-ETHOXYPHENOL)-, MONOHYDROCHLORIDE
N(SUP 1),N(SUP 2)-BIS(P-ETHOXYPHENYL)ACETAMIDINE HYDROCHLORIDE
PHENACAINE HYDROCHLORIDE MONOHYDRATE [MI]
N,N'-BIS(4-ETHOXYPHENYL)ETHANIMIDAMIDE MONOHYDROCHLORIDE MONOHYDRATE
N(SUP 1),N(SUP 2)-BIS(P-ETHOXYPHENYL)ACETAMIDINE HYDROCHLORIDE MONOHYDRATE
Acetamidine, N,N'-bis(p-ethoxyphenyl)-, monohydrochloride (8CI)
Ethanimidamide, N,N'-bis(4-ethoxyphenyl)-, monohydrochloride (9CI)
Holocaine hydrochloride
620-99-5
Phenacaine (Hydrochloride)
NSC-9293
N,N'-bis(4-ethoxyphenyl)ethanimidamide;hydrochloride
NCGC00181080-01
Ethanimidamide, N,N'-bis(4-ethoxyphenyl)-, hydrochloride (1:1); Acetamidine, N,N'-bis(p-ethoxyphenyl)-, hydrochloride (7CI); Acetamidine, N,N'-bis(p-ethoxyphenyl)-, monohydrochloride (8CI); Ethanimidamide, N,N'-bis(4-ethoxyphenyl)-, monohydrochloride (9CI); Holocaine hydrochloride; Phenacaine hydrochloride
N,N-bis-(p-Ethoxyphenyl)acetamidine hydrochloride
SCHEMBL24364
SCHEMBL24366
CHEMBL2107086
NSC9293
RRRKUSYYBYVFMC-UHFFFAOYSA-N
Tox21_113238
WLN: 2OR DNUY1&MR DO2 &GH
CAS-620-99-5
NS00080234
Acetamidine,N'-bis(p-ethoxyphenyl)-, hydrochloride
Acetamidine,N'-bis(p-ethoxyphenyl)-, monohydrochloride
Q27254507
Ethanimidamide,N'-bis(4-ethoxyphenyl)-, monohydrochloride