Clomipramine | Solubility of Things

Identification

Molecular formula

C₁₉H₂₃ClN₂

CAS number

303-49-1

IUPAC name

N',N'-dibenzyl-N-[(4-chlorophenyl)-phenyl-methyl]ethane-1,2-diamine

State

Clomipramine is typically found in a solid state at room temperature.

Melting point (Celsius)

190.00

Melting point (Kelvin)

463.20

Boiling point (Celsius)

392.60

Boiling point (Kelvin)

665.80

General information

Molecular weight

314.88g/mol

Molar mass

314.8810g/mol

Density

1.2673g/cm³

Appearence

Clomipramine appears as a white to slightly off-white crystalline powder. It is generally odorless but may have a faint characteristic odor.

Comment on solubility

Solubility of N',N'-dibenzyl-N-[(4-chlorophenyl)-phenyl-methyl]ethane-1,2-diamine

N',N'-dibenzyl-N-[(4-chlorophenyl)-phenyl-methyl]ethane-1,2-diamine is an organic compound with unique solubility characteristics. Understanding its solubility can be quite complex, as it is influenced by several factors:

Polarity: This compound features a mixed structure, which generally results in a moderate polarity. Such compounds tend to dissolve well in polar organic solvents but may have limited solubility in non-polar solvents.
Temperature: Solubility can be significantly increased at higher temperatures, as the kinetic energy helps overcome intermolecular forces.
pH Levels: The solubility may also vary with the pH of the solvent; basic or acidic conditions can alter the protonation state of the amine groups, thus affecting solubility.

As a general observation, many organic amines similar to this compound show good solubility in solvents such as:

Dimethyl sulfoxide (DMSO)
Methanol
Aqueous solutions with sufficient pH adjustments

In conclusion, while exact solubility data may be limited, it is essential to note that the presence of polar functional groups and molecular structure plays a critical role in the compound’s solubility profile. As with many organic compounds, it's always advised to conduct empirical solubility tests to gain specific insights.

Interesting facts

Interesting Facts about N',N'-dibenzyl-N-[(4-chlorophenyl)-phenyl-methyl]ethane-1,2-diamine

N',N'-dibenzyl-N-[(4-chlorophenyl)-phenyl-methyl]ethane-1,2-diamine is a fascinating compound that belongs to the category of chemical amines. Its unique structure and composition provide insight into its diverse applications and roles in various fields. Here are some engaging facts about this intriguing compound:

Diverse Applications: This compound is utilized in pharmaceuticals and medicinal chemistry, showcasing its potential in drug development due to its ability to create complex molecular structures.
Synthesis Challenges: The synthesis of this compound can present challenges, particularly in achieving the right configuration. This aspect can provide valuable learning experiences for aspiring chemists in understanding reaction mechanisms.
Biological Activity: Compounds with similar structural characteristics can exhibit interesting biological activities, ranging from antibacterial to anticancer properties. Researchers often explore these connections to find therapeutic agents.
Structure-Activity Relationship (SAR): The presence of various functional groups in this compound makes it a prime candidate for SAR studies, which help in understanding how changes in chemical structure affect biological activity.
Combination Chemistry: It can also be a key player in combinatorial chemistry, where multiple derivatives of this compound can be synthesized rapidly to screen for desirable properties.

In summary, N',N'-dibenzyl-N-[(4-chlorophenyl)-phenyl-methyl]ethane-1,2-diamine not only embodies a rich chemical structure but also serves as a valuable subject of study in medicinal chemistry and synthesis. As the field continues to advance, the exploration of compounds like this can lead to significant breakthroughs in drug discovery and design.