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Naloxone

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Identification
Molecular formula
C19H21NO2
CAS number
357-08-4
IUPAC name
N,N-diethyl-2-[3-(3-pyridyl)isoxazol-5-yl]ethanamine
State
State

At room temperature, naloxone is typically a solid, often encountered as a crystalline powder in its pure form. In clinical settings, naloxone is commonly found in aqueous solutions for injection.

Melting point (Celsius)
197.00
Melting point (Kelvin)
470.15
Boiling point (Celsius)
510.00
Boiling point (Kelvin)
783.15
General information
Molecular weight
327.37g/mol
Molar mass
327.3740g/mol
Density
1.2860g/cm3
Appearence

Naloxone is typically encountered as a white to slightly off-white powder. Pharmaceutical preparations may vary in appearance.

Comment on solubility

Solubility of N,N-Diethyl-2-[3-(3-pyridyl)isoxazol-5-yl]ethanamine

The solubility characteristics of N,N-diethyl-2-[3-(3-pyridyl)isoxazol-5-yl]ethanamine can be quite intriguing due to its complex molecular structure. Understanding the solubility of this compound is crucial for its application in various chemical processes and pharmaceutical formulations.

Factors Influencing Solubility

Several factors affect the solubility of this compound:

  • Polarity: The presence of polar functional groups can lead to increased solubility in polar solvents.
  • Hydrogen Bonding: Ability to form hydrogen bonds may enhance solubility in solvents that can participate in hydrogen bonding.
  • Molecular Size: Larger molecules often exhibit decreased solubility due to increased van der Waals forces.

Solvent Compatibility

This compound may exhibit different solubility behaviors in various solvents:

  • Apolar Solvents: Limited solubility is expected in apolar solvents like hexane.
  • Polar Protic Solvents: Enhanced solubility in solvents like water or alcohols due to potential interactions.
  • Polar Aprotic Solvents: Moderate solubility may occur in solvents such as DMSO or acetone.

In summary, while the exact solubility of N,N-diethyl-2-[3-(3-pyridyl)isoxazol-5-yl]ethanamine can vary, its solubility profile offers valuable insights for its utility in research and industrial applications. Understanding these solubility aspects is essential for optimizing conditions in practical scenarios.

Interesting facts

Interesting Facts about N,N-Diethyl-2-[3-(3-pyridyl)isoxazol-5-yl]ethanamine

N,N-Diethyl-2-[3-(3-pyridyl)isoxazol-5-yl]ethanamine is a fascinating compound with a unique structure and potential applications:

  • Pharmacological Potential: This compound belongs to a class of molecules known for their neuropharmacological properties. Research indicates that derivatives of isoxazole are often investigated for their ability to modulate neurotransmitter systems.
  • Structural Complexity: The incorporation of a pyridine ring introduces intriguing electronic properties that can influence the biological activity of the compound. Pyridine is known for its aromaticity and ability to participate in hydrogen bonding, which may enhance the binding of the molecule to its targets.
  • Isomer Significance: The isoxazole moiety is notable in medicinal chemistry as it serves as a scaffold for various drug candidates. Its structural features can lead to varied pharmacokinetic and pharmacodynamic profiles.
  • Research and Development: Ongoing studies may evaluate the compound for therapeutic applications, particularly in contexts such as anxiety and depression, where modulation of neurotransmitters like serotonin and norepinephrine is critical.
  • Structure-Activity Relationship (SAR): The exploration of N,N-diethyl-2-[3-(3-pyridyl)isoxazol-5-yl]ethanamine contributes to our understanding of SAR, which is vital for the design of more effective pharmacological agents.

In conclusion, the complex interplay between the various functional groups in N,N-diethyl-2-[3-(3-pyridyl)isoxazol-5-yl]ethanamine highlights the importance of structural nuances in drug discovery. As research advances, this compound may lead to exciting developments in therapeutic solutions.