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Loratadine

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Identification
Molecular formula
C22H23ClN2O2
CAS number
79794-75-5
IUPAC name
N,N-diethyl-2-[(3-methoxy-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]ethanamine
State
State

At room temperature, loratadine exists as a solid.

Melting point (Celsius)
134.00
Melting point (Kelvin)
407.20
Boiling point (Celsius)
373.40
Boiling point (Kelvin)
646.50
General information
Molecular weight
382.88g/mol
Molar mass
382.8800g/mol
Density
1.0100g/cm3
Appearence

Loratadine is typically found as a white to off-white crystalline powder. It is generally odorless and tasteless.

Comment on solubility

Solubility of N,N-Diethyl-2-[(3-Methoxy-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]ethanamine

The solubility of N,N-diethyl-2-[(3-methoxy-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]ethanamine is an intriguing aspect of this compound, given its complex structure.

In general, the solubility characteristics of this compound can be influenced by several factors:

  • Polarity: The presence of the ethyl groups and the ether functional group may suggest some degree of polarity, impacting its solubility in polar solvents such as water.
  • Hydrophobic Characteristics: The cyclohepta[b]quinoline moiety contributes hydrophobic characteristics, making it potentially less soluble in water but more soluble in organic solvents like ethanol or chloroform.
  • Functional Groups: The methoxy group adds to the overall solubility profile, as it can engage in hydrogen bonding, possibly increasing solubility in polar environments.

As a result, this compound may exhibit:

  1. Moderate solubility in organic solvents.
  2. Lower solubility in aqueous solutions depending on pH and temperature conditions.

Ultimately, the solubility behavior of N,N-diethyl-2-[(3-methoxy-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]ethanamine may require empirical testing to fully characterize, as the interplay of structural nuances and environmental factors can substantially influence its solubility profile. As solubility is a key parameter in determining the compound's utility and behavior in various applications, a thorough understanding is essential.

Interesting facts

Interesting Facts about N,N-Diethyl-2-[(3-Methoxy-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]ethanamine

N,N-Diethyl-2-[(3-methoxy-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]ethanamine is an intriguing compound with a variety of applications and characteristics that make it a subject of interest in both medicinal chemistry and pharmacology. Here are a few remarkable insights about this compound:

  • Potential Therapeutic Uses: This compound belongs to a class of chemical entities with promising pharmacological activities, particularly in areas such as neuroprotection and the treatment of neurodegenerative diseases.
  • Cyclohepta[b]quinoline Framework: The incorporation of a cyclohepta[b]quinoline moiety is significant as it contributes to the compound's unique pharmacokinetic profile and may influence its interaction with biological targets.
  • Structure-Activity Relationship: Variations in the structure of this compound, particularly the substitutions on the nitrogen atoms and the ethyl groups, can drastically influence its biological activity, making it an exciting compound for structure-activity relationship studies.
  • Oxygen Functionality: The ether-like functional group introduced by the methoxy linkage may enhance solubility and bioavailability, which is crucial for effective therapeutic applications.
  • Research and Development: Ongoing research is exploring the implications of this compound in various biological assays, highlighting its potential to unlock new pathways in drug discovery.

As a chemistry student or scientist, it's fascinating to delve into the complexities of such compounds. The intricate balance of structure and function underscores the importance of molecular design in pharmacology. In the words of a renowned chemist, 'The design of a molecule is only the beginning; the interactions it has define its fate in a biological system.' This emphasizes the continuous pursuit of understanding how compounds like N,N-diethyl-2-[(3-methoxy-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]ethanamine can transform the landscape of medicinal chemistry.