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Nilutamide

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Identification
Molecular formula
C12H12N4O4
CAS number
63612-50-0
IUPAC name
N,N-diethyl-2-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]ethanamine
State
State

At room temperature, nilutamide is typically a solid.

Melting point (Celsius)
144.00
Melting point (Kelvin)
417.15
Boiling point (Celsius)
263.00
Boiling point (Kelvin)
536.15
General information
Molecular weight
317.38g/mol
Molar mass
317.3800g/mol
Density
1.3180g/cm3
Appearence

Nilutamide appears as a white to off-white crystalline powder. It is practically insoluble in water but soluble in organic solvents like methanol, ethanol, and chloroform.

Comment on solubility

Solubility of N,N-Diethyl-2-[5-Nitro-2-[2-(1-Piperidyl)ethyl]benzimidazol-1-yl]ethanamine

N,N-Diethyl-2-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]ethanamine is a complex organic compound that exhibits varied solubility characteristics.

  • Solvent Compatibility: This compound is generally more soluble in organic solvents than in water. It is often found to dissolve well in solvents such as ethanol, dimethyl sulfoxide (DMSO), and acetone.
  • Polar vs. Non-Polar Solvents: Given the presence of aromatic and nitrogen-containing functional groups, N,N-diethyl-2-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]ethanamine may show increased solubility in moderately polar solvents rather than highly polar solvents like water.
  • Temperature Dependence: The solubility can also be influenced by temperature; typically, an increase in temperature can lead to increased solubility in organic solvents.

As a general observation, complex molecules like this one often require careful consideration of their solubility for practical applications, such as in drug formulation or chemical synthesis. Therefore, when working with this compound, it is essential to conduct solubility tests in various solvents to determine the most effective conditions for its use.

Interesting facts

Interesting Facts about N,N-Diethyl-2-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]ethanamine

N,N-Diethyl-2-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]ethanamine is a fascinating compound with notable implications in various fields of science, particularly in medicinal chemistry.

Key Features

  • Structure Complexity: This compound features a unique arrangement that combines a benzimidazole ring with nitro and piperidine substituents, which play significant roles in its biological activity.
  • Biological Activity: Compounds with benzimidazole structures are often investigated for their pharmacological properties, including anti-cancer, anti-parasitic, and anti-inflammatory effects.
  • Use in Research: Researchers often explore such compounds as potential drug candidates, providing insights into their mechanism of action and therapeutic potential.

Applications

Many compounds similar to N,N-diethyl-2-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]ethanamine have been used in:

  • Antimicrobial therapies
  • Targeting specific enzymes or receptors in cells
  • Drug design and modification efforts to enhance efficacy and reduce side effects

Quote for Inspiration

As the renowned chemist, Robert H. Grubbs, once said, "Chemistry is like cooking; just don't lick the spoon." This emphasizes the importance of safety and precision in the exploration of complex compounds like this one.

Overall, the exploration of N,N-diethyl-2-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]ethanamine reflects the intriguing interplay between chemical structure and biological function, a fundamental principle in the field of medicinal chemistry.