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Clonidine

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Identification
Molecular formula
C18H21ClN4O4
CAS number
4205-91-8
IUPAC name
N,N-diethyl-2-[5-nitro-2-(2-piperidin-1-ium-1-ylethyl)benzimidazol-1-yl]ethanamine;chloride
State
State

Clonidine is solid at room temperature.

Melting point (Celsius)
184.50
Melting point (Kelvin)
457.65
Boiling point (Celsius)
352.00
Boiling point (Kelvin)
625.15
General information
Molecular weight
266.56g/mol
Molar mass
266.5610g/mol
Density
1.3000g/cm3
Appearence

In its base form, Clonidine is typically a white to off-white crystalline powder.

Comment on solubility

Solubility of N,N-diethyl-2-[5-nitro-2-(2-piperidin-1-ium-1-ylethyl)benzimidazol-1-yl]ethanamine;chloride

The compound N,N-diethyl-2-[5-nitro-2-(2-piperidin-1-ium-1-ylethyl)benzimidazol-1-yl]ethanamine;chloride exhibits unique solubility characteristics that are essential for its functionality in various applications.

Understanding its solubility can be approached by considering the following factors:

  • Ionic vs. Non-Ionic Nature: As a salt formed with chloride, this compound is likely to exhibit increased solubility in polar solvents compared to non-polar solvents.
  • Hydrophobic and Hydrophilic Balance: The presence of the piperidine moiety contributes to its polar characteristics, suggesting a moderate solubility in water, dependent on the degree of protonation.
  • Temperature Dependency: The solubility may vary with temperature, with higher temperatures potentially increasing solubilization due to enhanced molecular motion.
  • Effect of Substituents: The nitro group and the overall molecular structure may play a role in hydrogen bonding, further influencing solubility in aqueous and organic phases.

In summary, this compound is expected to be soluble in polar solvents due to its ionic nature and polar functional groups. However, its solubility can be significantly influenced by environmental factors such as pH and temperature.

Interesting facts

Exciting Insights into N,N-Diethyl-2-[5-Nitro-2-(2-piperidin-1-ium-1-ylethyl)benzimidazol-1-yl]ethanamine; Chloride

N,N-Diethyl-2-[5-nitro-2-(2-piperidin-1-ium-1-ylethyl)benzimidazol-1-yl]ethanamine; chloride is a remarkable compound that showcases the fascinating interplay between organic chemistry and medicinal applications. Here are some captivating facts about this compound:

  • Versatile Applications: This compound can serve as a potential pharmacological agent, owing to its unique structure which is indicative of its capability to interact with biological systems.
  • Structural Diversity: The compound features a benzimidazole ring, a motif known for its biological activities, including anti-cancer, anti-viral, and anti-parasitic properties.
  • Piperidine Charm: The inclusion of a piperidine moiety enhances the lipophilicity of the compound, which can influence its absorption and distribution in biological systems, making it a subject of interest in drug design.
  • Nitro Group Influence: The presence of the nitro group is significant as it can act as an electronic and steric modification, potentially affecting the reactivity and pharmacological effects of the compound.
  • Positive Charge: The piperidin-1-ium group contributes a positive charge, which may increase the solubility of the compound in biological fluids, a critical factor for therapeutic applications.

This compound exemplifies how subtle modifications in structure can lead to significant variations in biological activity. As a chemist, exploring such compounds not only enriches our understanding of chemical properties but also expands the horizon of therapeutic possibilities. The future of compounds like N,N-Diethyl-2-[5-Nitro-2-(2-piperidin-1-ium-1-ylethyl)benzimidazol-1-yl]ethanamine; chloride may hold the key to developing new treatment methodologies.

Synonyms
1-(2-Diethylaminoethyl)-5-nitro-2-piperidinoethylbenzimidazole hydrochloride
17817-85-5
BENZIMIDAZOLE, 1-(2-DIETHYLAMINOETHYL)-5-NITRO-2-PIPERIDINOETHYL-, HYDROCHLORIDE