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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
N,N-diethyl-4-methyl-piperazine-1-carboxamide
State
State

At room temperature, lidocaine is in a solid state when in its pure form. However, for medical use, it is commonly prepared as a liquid solution for injections or as a topical formulation for creams and gels.

Melting point (Celsius)
68.00
Melting point (Kelvin)
341.15
Boiling point (Celsius)
180.00
Boiling point (Kelvin)
453.15
General information
Molecular weight
234.34g/mol
Molar mass
234.3430g/mol
Density
1.0300g/cm3
Appearence

Lidocaine appears as a white to slightly yellow crystalline powder. It is odorless and has a slightly bitter taste. When used in medical formulations, it is often found in a solution or cream form.

Comment on solubility

Solubility of N,N-Diethyl-4-methyl-piperazine-1-carboxamide (C14H22N2O)

N,N-Diethyl-4-methyl-piperazine-1-carboxamide, due to its structure, exhibits notable solubility characteristics. This compound's solubility can be influenced by several factors such as polarity, hydrogen bonding, and molecular interactions:

  • Polarity: The presence of both the carbonyl and amine groups in the molecule enhances its polarity, allowing it to interact effectively with polar solvents.
  • Hydrogen Bonding: The capability of the amide group to participate in hydrogen bonding facilitates its solubility in water and other polar solvents.
  • Organic Solvents: It is also soluble in various organic solvents, including ethanol, which can accommodate its moderate polarity.

In general, N,N-diethyl-4-methyl-piperazine-1-carboxamide is expected to be:

  1. Soluble in polar solvents like water due to hydrogen bonding capability.
  2. Soluble in organic solvents such as ethanol and methanol.

This unique combination of functional groups contributes to its enhanced solubility profile, making it versatile for various chemical applications. As a result, understanding the solubility characteristics of this compound is critical for its effective use in both laboratory and industrial settings.

Interesting facts

Interesting Facts about N,N-Diethyl-4-methyl-piperazine-1-carboxamide

N,N-Diethyl-4-methyl-piperazine-1-carboxamide is a fascinating compound with various applications and properties. Here are some engaging insights about this chemical:

  • Medicinal Importance: This compound belongs to a class of piperazine derivatives, which are known for their pharmacological activities. Researchers have studied their potential in developing new medications that target various conditions, including anxiety and depression.
  • Structural Integrity: The unique structure comprising a piperazine ring contributes to its chemical stability and reactivity. Piperazine is a six-membered ring containing two nitrogen atoms, enhancing its interaction with biological systems.
  • Synthesis and Utility: The synthesis of N,N-diethyl-4-methyl-piperazine-1-carboxamide can involve straightforward methods, serving as a precursor in the synthesis of other compounds. This versatility makes it a valuable asset in organic chemistry laboratories.
  • Research Potential: Due to its structural characteristics, scientists are continually exploring its properties for applications in drug design and development. Compounds from the piperazine family often serve as scaffolds in the synthesis of more complex molecules.
  • Application in Pharmaceuticals: The compound's ability to act on certain receptors in the brain opens avenues for its use in treating neurological disorders, where its piperazine backbone might influence its affinity for specific targets.
  • Safety Considerations: As with many organic compounds, understanding the safety and toxicity profiles of N,N-diethyl-4-methyl-piperazine-1-carboxamide is crucial for its use in industrial and research settings.

In summary, N,N-diethyl-4-methyl-piperazine-1-carboxamide exemplifies the intriguing world of synthetic organic compounds, merging the realms of chemistry and pharmacology. Its potential continues to unfold as research progresses, aiming to harness its properties for innovative solutions in medicine and beyond.

Synonyms
diethylcarbamazine
90-89-1
N,N-diethyl-4-methylpiperazine-1-carboxamide
Carbamazine
Carbilazine
Ethodryl
Diethyl carbamazine
Bitirazine
Cypip
Ditrazine Base
Caracide
Caricide
Notezine
Spatonin
N,N-Diethyl-4-methyl-1-piperazinecarboxamide
Dietilcarbamazina
N,N-Diethylcarbamazine
1-Piperazinecarboxamide, N,N-diethyl-4-methyl-
Diaethylcarbamazinum
Camin
Diethylcarbamazinum
Diethylcarbamazine [INN:BAN]
Diethylcarbamazinum [INN-Latin]
Dietilcarbamazina [INN-Spanish]
Camin (TN)
Diethylcarbamazine (INN)
EINECS 202-023-3
BRN 0143029
CHEBI:4527
V867Q8X3ZD
AI3-19612
84L
DIETHYLCARBAMAZINE [MI]
DIETHYLCARBAMAZINE [INN]
Bitirazine; Caracide;Carbamazine
DTXSID1022928
EC 202-023-3
DIETHYLCARBAMAZINE [WHO-DD]
4-23-00-00225 (Beilstein Handbook Reference)
MMV002816
Diethylcarbamazinum (INN-Latin)
Dietilcarbamazina (INN-Spanish)
NSC1364
1-Diethylcarbamoyl-4-Methylpiperazine
UNII-V867Q8X3ZD
1-Diethylcarbamyl-4-methylpiperazine
1-Methyl-4-diethylcarbamoylpiperazine
MFCD00023288
Banocide (Salt/Mix)
Caritrol (Salt/Mix)
Nemacide (Salt/Mix)
Spectrum_000938
NN-Diethyl-4-methyl-1-piperazinecarboxamide
Prestwick0_000284
Prestwick1_000284
Prestwick2_000284
Prestwick3_000284
Spectrum2_001022
Spectrum3_000390
Spectrum4_000511
Spectrum5_000877
CHEMBL684
SCHEMBL67289
BSPBio_000188
BSPBio_002179
ditrazinum (for the citrate)
KBioGR_001081
KBioSS_001418
DivK1c_000548
SPBio_001203
SPBio_002407
BPBio1_000208
DTXCID802928
KBio1_000548
KBio2_001418
KBio2_003986
KBio2_006554
KBio3_001399
P02CB02
NINDS_000548
HMS3604F12
1-Diethylcarbamoyl-4-methylpiperzine
HY-12642A
AKOS003268016
DB00711
DS-9360
IDI1_000548
s10791
NCGC00178778-01
NCGC00178778-02
NCGC00178778-07
SBI-0051345.P003
DB-080764
R.P. 3799
1-(N,N-Diethylcarbamoyl)-4-methylpiperazine
AB00053457
CS-0013568
NS00000124
C07968
D07825
EN300-119374
N,N-diethyl-4-methyl-piperazine-1-carboxamide
AB00053457_12
Q409267
SR-01000759234-8
BRD-K45542189-048-05-6
BRD-K45542189-048-15-5
BRD-K45542189-048-22-1
Z641623606
202-023-3