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Pretomanid hydrochloride

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Identification
Molecular formula
C14H20ClN3S
CAS number
1872356-06-2
IUPAC name
N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine;hydrochloride
State
State

At room temperature, pretomanid hydrochloride is typically found as a solid in crystalline form.

Melting point (Celsius)
130.00
Melting point (Kelvin)
403.15
Boiling point (Celsius)
215.00
Boiling point (Kelvin)
488.15
General information
Molecular weight
308.85g/mol
Molar mass
608.1400g/mol
Density
1.1900g/cm3
Appearence

Pretomanid hydrochloride typically appears as a white to off-white crystalline solid.

Comment on solubility

Solubility of N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine;hydrochloride

The solubility of N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine;hydrochloride can be influenced by several factors. This compound, as a hydrochloride salt, typically exhibits improved solubility in aqueous solutions compared to its free base form. Here are some key points regarding its solubility:

  • High Solubility in Water: As a hydrochloride, it is generally more soluble in water due to the ionic nature imparted by the hydrochloride, enhancing its dissociation in aqueous environments.
  • Temperature Dependence: Solubility may increase with temperature, a common trait for many salts, potentially leading to greater dissolution in warm solutions.
  • Influence of pH: The solubility can be affected by the pH level of the solution. In more acidic conditions, the compound may remain more soluble.
  • Organic Solvents: While its solubility in organic solvents may be limited, certain polar organic solvents like methanol or ethanol might facilitate some degree of solubility.

In conclusion, the solubility of N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine;hydrochloride is significantly enhanced as a hydrochloride salt, providing essential properties for various applications in pharmaceutical formulations. Understanding these solubility characteristics is crucial for optimizing its use in medicinal chemistry.

Interesting facts

Interesting Facts about N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine;hydrochloride

N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine;hydrochloride is a fascinating compound that intertwines elements of both organic chemistry and medicinal applications. Here are some engaging highlights:

  • Structural Complexity: The compound boasts a unique and intricate structure, combining a benzothiazine core with a pyridine ring. This structural diversity contributes to its potential biological activity.
  • Pharmacological Potential: Compounds containing similar structural features have been explored for their pharmacological properties, particularly in the development of therapeutics targeting neurological and psychiatric disorders.
  • Mechanism of Action: While the precise mechanism of action for this class of compounds is still under investigation, it is hypothesized that interactions with neurotransmitter systems may play a critical role.
  • Research Interest: Ongoing research is examining the synthesis and modification of this compound to enhance its efficacy and reduce potential side effects, thus paving the way for new drug candidates.

The study of N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine;hydrochloride exemplifies the dynamic nature of chemistry whereby the exploration of complex molecular frameworks not only enriches our understanding of chemical properties but also expands our arsenal of tools in combating diseases. As we delve deeper into the world of heterocyclic compounds, the potential for novel discoveries continually unfolds.

"Chemistry is the art of scientific exploration, revealing the intricate relationships between structure and function!"

Synonyms
isothipendyl hydrochloride
1225-60-1
Andantol
Theruhistin
Adantol
Isothipendyl HCl
Isothipendyl (hydrochloride)
Isothipendyl monohydrochloride
Isothipendyl hydrochloride [JAN]
Nilergex
NSC-169186
10-(2-Dimethylaminopropyl)-10H-pyrido(3,2-b)(1,4)benzothiazine hydrochloride
N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-2-amine;hydrochloride
953AP1LBV8
N-Dimethylaminoisopropylthiophenylpyridylamine hydrochloride
34433-15-3
DTXSID1046845
(+/-)-ISOTHIPENDYL HYDROCHLORIDE
a-Isothipendyl Hydrochloride
10H-Pyrido(3,2-b)(1,4)benzothiazine-10-ethanamine, N,N,2-trimethyl-, monohydrochloride
Adanton hydrochloride
Udantol hydrochloride
Nilergex hydrochloride
Isothipendyl hydrochloride (JAN)
Theruhistin hydrochloride
EINECS 214-957-9
NSC 169186
UNII-953AP1LBV8
EINECS 252-022-7
10-(2-Dimethylaminopropyl)-1-azaphenothiazine hydrochloride
Dimethylamino-isopropyl-thiophenyl-pyridylamin hydrochlorid [German]
NCGC00181101-01
10-(2-Dimethylaminopropyl)-(1)-4-azaphenthiazin hydrochlorid [German]
10-(2-Dimethylaminopropyl)-9-thia-1,10-diazaanthracene hydrochloride
10-(2-Dimethylamino-2-methylethyl)-10H-pyrido(3,2-b)(1,4)benzothiazine hydrochloride
10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(2-(dimethylamino)propyl)-, monohydrochloride
SCHEMBL230214
CHEMBL2107246
DTXCID9026845
CHEBI:31734
HY-A0178A
Dimethylamino-isopropyl-thiophenyl-pyridylamin hydrochlorid
RQHCFTORMXCNGP-UHFFFAOYSA-N
10-(2-Dimethylaminopropyl)-(1)-4-azaphenthiazin hydrochlorid
Tox21_112717
NSC169186
AKOS037503833
FI30144
ISOTHIPENDYL HYDROCHLORIDE [MI]
10-(2-(Dimethylamino)propyl)-10H-pyrido(3,2-b)(1,4)benzothiazine hydrochloride
10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(2-dimethylamino-2-methylethyl)-, hydrochloride
ISOTHIPENDYL HYDROCHLORIDE [MART.]
CAS-1225-60-1
ISOTHIPENDYL HYDROCHLORIDE [WHO-DD]
CS-0108257
ISOTHIPENDYL HYDROCHLORIDE, (+/-)-
NS00080829
NS00087339
D01143
Q27271733
10H-Pyrido[3,4]benzothiazine, 10-(2-dimethylamino-2-methylethyl)-, hydrochloride
10H-Pyrido[3,4]benzothiazine, 10-[2-(dimethylamino)propyl]-, monohydrochloride
10H-Pyrido[3,4]benzothiazine-10-ethanamine, N,N,2-trimethyl-, monohydrochloride
N,N,alpha-Trimethyl-10H-pyrido[3,2-b][1,4]benzothiazine-10-ethanamine Hydrochloride