Interesting facts
Interesting Facts about N,N-Dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide
N,N-Dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide, commonly referred to in scientific literature as a phenothiazine derivative, is a notable compound extensively researched for its pharmacological properties. Here are some compelling insights about this compound:
- Pharmacological Potential: Compounds like this one are often explored for their potential as antipsychotic medications. They target neurotransmitter systems, particularly dopamine receptors, which are crucial for regulating mood and behavior.
- Structure-Activity Relationship: The complex structure of this compound plays a significant role in its biological activity. The presence of functional groups, such as sulfonamide and piperazine, enhances its efficacy and modulates its interaction with biological targets.
- Mechanism of Action: Research suggests that phenothiazine derivatives may act by blocking dopaminergic and serotonergic receptors in the brain, making them valuable in treating various psychiatric disorders. Their dual-action approach to modulation could lead to innovative therapeutic strategies.
- Side Effects: While they can be effective, phenothiazines also carry the risk of side effects, including sedation, weight gain, and extrapyramidal symptoms. Understanding these aspects is critical for improving patient outcomes.
- Research and Development: Ongoing studies are evaluating modifications to this molecule’s structure to enhance its therapeutic index and reduce adverse effects. As a result, such research efforts could pave the way for new medications targeting psychiatric conditions.
In summary, N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide is more than just a chemical compound; it's a representation of the intricate relationships between chemistry and medicine. As stated by many pharmacologists, "Understanding the chemistry behind drug interactions is essential in the quest for effective therapies."
The exploration of compounds like this can significantly contribute to advances in pharmacotherapy, enhancing the quality of life for individuals with mental health conditions.
Synonyms
Thioproperazine
316-81-4
Thioperazine
Thioproperazin
Sulfenazin
Tioproperazin
Cephalmin
Majeptyl
Mazeptyl
Megeptil
Vontil
Tioproperazina
Thiproperazine
Tioproferazina
Thioproperazinum [INN-Latin]
Tioproferazina [INN-Spanish]
Thioproperazinum
Mazeptil
Thioproperazine [INN]
Tioproperazina [DCIT]
N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide
SKF 5883
RP 7843
10H-Phenothiazine-2-sulfonamide,N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-
Thioproperazine [INN:BAN]
EINECS 206-262-4
UNII-YJ050AQ56X
YJ050AQ56X
CHEBI:59120
7843 R.P.
Thioproperazine (INN)
(Thioproperazine)-2-dimethylsulfamido-(10-(3-1-methylpiperazinyl-4)propyl)-phenothiazine
THIOPROPERAZINE [MI]
N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine-2-sulfonamide
10H-Phenothiazine-2-sulfonamide, N,N-dimethyl-10-(3-(4-methyl-1-piperazinyl)propyl)-
DTXSID1023655
THIOPROPERAZINE [WHO-DD]
RP 7843; SKF 5883; Sulfenazin; Thioperazine
2-dimethylsulfamido-(10-(3-1-methylpiperazinyl-4)propyl)-phenothiazine
N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide
N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine-2-sulfonamide
N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine-2-sulfonamide
10H-Phenothiazine-2-sulfonamide, N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-
PHENOTHIAZINE-2-SULFONAMIDE, N,N-DIMETHYL-10-(3-(4-METHYL-1-PIPERAZINYL)PROPYL)-
Thioproperazinum (INN-Latin)
Tioproferazina (INN-Spanish)
Thioproperazine methanesulfonate
Phenothiazine-2-sulfonamide, N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-
N,N-Dimethyl-10-(3-(4-methyl-1-piperazinyl)propyl)-10H-phenothiazine-2-sulfonamide
N,N-Dimethyl-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine-2-sulfonamide
Prestwick0_000149
Prestwick1_000149
Prestwick2_000149
Prestwick3_000149
SCHEMBL49902
BSPBio_000258
SPBio_002197
BPBio1_000284
CHEMBL609109
DTXCID003655
BDBM81793
N05AB08
HY-A0151
NSC_92178
PDSP1_000526
PDSP2_000524
AKOS015895993
DB01622
DS-3246
NCGC00179625-01
CAS_316-81-4
DA-68159
CS-0017476
NS00006935
A11527
D08585
L000962
Q2622839
BRD-K08619574-334-03-9
BRD-K08619574-334-05-4
N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine-2-sulfonamide #
206-262-4
Thioproperazine dimesylate;3-Dimethylsulfamido-10-[3-(4-methylpiperazino)propyl]phenothiazine Dimethanesulfonate;N,N-dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide
Solubility of N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide
The solubility of N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide can be influenced by various factors and is crucial for its application in pharmaceutical formulations. This compound, with its complex molecular structure, generally exhibits the following characteristics regarding solubility:
In conclusion, while N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide shows potential for good solubility in specific conditions due to its polar functional groups, care must be taken to consider its overall solubility profile when developing formulations.