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5-Dimethylaminoindole

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Identification
Molecular formula
C10H12N2
CAS number
1152-93-6
IUPAC name
N,N-dimethyl-1H-indol-5-amine
State
State

At room temperature, 5-Dimethylaminoindole is typically found in a solid state, existing as a powder or crystalline solid.

Melting point (Celsius)
129.00
Melting point (Kelvin)
402.20
Boiling point (Celsius)
376.10
Boiling point (Kelvin)
649.30
General information
Molecular weight
174.22g/mol
Molar mass
174.2360g/mol
Density
1.1570g/cm3
Appearence

5-Dimethylaminoindole appears as a white or off-white crystalline powder that may tan slightly upon exposure to air or light. The compound has a tendency to form well-defined crystals and is sensitive to prolonged exposure to light, which may result in discoloration.

Comment on solubility

Solubility of N,N-dimethyl-1H-indol-5-amine

N,N-dimethyl-1H-indol-5-amine, a derivative of indole, exhibits specific solubility characteristics that are essential for its applications in various chemical processes. The solubility profile of a compound can greatly influence its behavior in reactions and its utility in pharmaceuticals and biochemistry.

Key aspects of the solubility of N,N-dimethyl-1H-indol-5-amine include:

  • Solvent Dependency: This compound is generally soluble in polar organic solvents such as ethanol and methanol due to its amine group, which can interact favorably with solvent molecules.
  • Water Solubility: The solubility of N,N-dimethyl-1H-indol-5-amine in water may be limited, reflecting its hydrophobic nature associated with the indole structure.
  • Temperature Influence: Increasing temperature can enhance solubility, allowing for better dissolution in various solvents.
  • pH Effects: The solubility can vary with pH, as the ionization of the amine group may either enhance or restrict the solubility in aqueous environments.

Overall, understanding the solubility of N,N-dimethyl-1H-indol-5-amine is crucial for formulating effective recipes in organic synthesis and pharmaceutical applications. As the saying goes, "Like dissolves like", which highlights the importance of selecting compatible solvents for optimal performance.

Interesting facts

Interesting Facts About N,N-Dimethyl-1H-Indol-5-amine

N,N-Dimethyl-1H-indol-5-amine, also known as DMIA, is an intriguing compound that has garnered attention in both chemical and biological research. Below are some fascinating insights about this compound:

1. Chemical Structure & Properties

This compound features an indole structure, which is a common motif in many biologically active molecules. The presence of the dimethylamine group enhances its reactivity and potential functionality, making it an interesting subject for synthesis and study.

2. Biological Significance

DMIA is often researched for its potential roles in pharmacology and medicinal chemistry. Some key points include:

  • Neurotransmitter Interactions: The indole derivative can interact with neurotransmitter receptors, possibly influencing neurological pathways.
  • Antimicrobial Activities: Some studies suggest that similar compounds exhibit antimicrobial properties, paving the way for potential therapeutic applications.
  • Drug Development: Its structure serves as a blueprint for the design of new pharmaceuticals aimed at treating various conditions.

3. Synthesis & Reactions

DMIA can be synthesized through various organic reactions, often involving:

  • Methylation Reactions: The introduction of methyl groups is crucial for enhancing the compound's properties.
  • Indole Derivatives: Leveraging known methods of indole synthesis allows for effective production of this compound.

4. Research Developments

As research into DMIA progresses, scientists are continually uncovering new aspects of its behavior. For instance:

  • Investigations into its pharmacokinetics explore how the compound behaves in biological systems.
  • Studies focused on the structure-activity relationship (SAR) can lead to the discovery of more potent analogs.

Conclusion

N,N-Dimethyl-1H-indol-5-amine is a compound rich in research potential across various domains of chemistry and biology. Its unique properties and interactions underscore the importance of continued exploration in both synthetic methodologies and pharmacological studies. As noted by chemists, "The more we understand the structures of complex molecules, the more we unlock the secrets of their functions."

Synonyms
N,N-dimethyl-1H-indol-5-amine
6843-23-8
INDOLE, 5-(DIMETHYLAMINO)-
5-(Dimethylamino)indole
1H-Indol-5-amine, N,N-dimethyl-
BRN 0386931
5-dimethylaminoindole
5-22-10-00012 (Beilstein Handbook Reference)
SCHEMBL3335239
DTXSID60218548
(1H-Indol-5-yl)-dimethyl-amine
AKOS022844945
DB-387369