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Methadone

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Identification
Molecular formula
C21H27NO
CAS number
76-99-3
IUPAC name
N,N-dimethyl-2-(1-methylpyrrolidin-3-yl)-2,2-diphenyl-acetamide
State
State

At room temperature, methadone exists as a solid. It is usually handled as a powder or in solution form.

Melting point (Celsius)
235.50
Melting point (Kelvin)
508.65
Boiling point (Celsius)
155.50
Boiling point (Kelvin)
428.65
General information
Molecular weight
309.45g/mol
Molar mass
309.4500g/mol
Density
0.9785g/cm3
Appearence

Methadone is typically available as a white crystalline powder. It dissolves well in water and alcohol and is often dispensed in liquid form for medical purposes due to its solubility properties. This compound is known for its bitter taste.

Comment on solubility

Solubility of N,N-Dimethyl-2-(1-Methylpyrrolidin-3-yl)-2,2-Diphenyl-Acetamide

N,N-dimethyl-2-(1-methylpyrrolidin-3-yl)-2,2-diphenyl-acetamide, a complex organic compound, presents interesting characteristics in terms of solubility. Understanding its solubility is crucial for its applications in pharmaceuticals and chemical synthesis.

General Solubility Characteristics

  • Polar vs. Nonpolar Solvents: This compound is likely to exhibit greater solubility in nonpolar solvents due to the presence of multiple phenyl groups, which can disrupt polar interactions.
  • Hydrogen Bonding: The amide functional group may participate in hydrogen bonding, potentially enhancing solubility in polar solvents to some extent.
  • Concentration Dependence: The solubility may vary significantly with concentration, as factors like the intermolecular forces and temperature can influence dissolution.

While specific solubility values in water and common organic solvents are typically not provided in general literature for such compounds, the overall tendency can be inferred from its chemical structure. The presence of bulky phenyl groups suggests steric hindrance, potentially reducing solubility in aqueous environments.

Practical Considerations

  • In laboratory settings, it is advisable to assess solubility in a range of solvents to determine the most suitable medium for its use.
  • Experimentation under varying conditions (temperature, pH) might yield interesting insights into its solubility behavior.

In conclusion, the solubility of N,N-dimethyl-2-(1-methylpyrrolidin-3-yl)-2,2-diphenyl-acetamide is influenced by its chemical structure and environmental conditions, making it a compound of interest for further research.

Interesting facts

Interesting Facts about N,N-Dimethyl-2-(1-methylpyrrolidin-3-yl)-2,2-diphenyl-acetamide

N,N-Dimethyl-2-(1-methylpyrrolidin-3-yl)-2,2-diphenyl-acetamide is a striking compound that plays a significant role in the field of medicinal chemistry. This complex structure combines elements of both artisanal organic synthesis and pharmaceutical application. Here are some key points to consider:

  • Pharmaceutical Relevance: This compound showcases promising properties in drug development, especially in the realm of analgesics and anesthetic agents. Its unique structure allows it to interact with various biological targets.
  • Structure-Activity Relationship: The presence of a diphenyl group combined with a pyrrolidine moiety contributes to the compound's potency. Understanding how these substituents influence biological activity is key to optimizing therapeutic outcomes.
  • Synthetic Pathways: The synthesis of this compound requires careful control of reaction conditions. Researchers often explore various synthetic routes to enhance yields and reduce by-products, making it a fascinating case study in organic synthesis.
  • Biological Mechanisms: Investigating the pharmacodynamics and pharmacokinetics of this molecule can reveal insights into its mechanism of action, particularly how it interacts with the nervous system.
  • Rational Drug Design: The development of N,N-dimethyl-2-(1-methylpyrrolidin-3-yl)-2,2-diphenyl-acetamide exemplifies the principles of rational drug design, where molecular modifications are informed by previous research findings, enhancing efficacy and safety.

As a compound that bridges the gap between small-molecule chemistry and biological application, N,N-dimethyl-2-(1-methylpyrrolidin-3-yl)-2,2-diphenyl-acetamide serves as a prime example for both aspiring chemists and seasoned researchers alike. Engaging with its fascinating aspects can inspire innovative approaches in medicinal chemistry.

Synonyms
SV24V1QAB0
UNII-SV24V1QAB0
N,N-DIMETHYL-2-(1-METHYLPYRROLIDIN-3-YL)-2,2-DIPHENYL-ACETAMIDE
902-76-1
N,N,1-Trimethyl-alpha,alpha-diphenyl-3-pyrrolidineacetamide
alpha-(1-Methyl-3-pyrrolidyl)-alpha,alpha-diphenyl-N,N-dimethylacetamide
SCHEMBL11725897
DTXSID90274531
OSIWLFYMANDEML-UHFFFAOYSA-N
N,N,1-TRIMETHYL-.ALPHA.,.ALPHA.-DIPHENYL-3-PYRROLIDINEACETAMIDE
N,N-Dimethyl-alpha,alpha-diphenyl-alpha-(1-methyl-3-pyrrolidinyl) acetamide
.ALPHA.-(1-METHYL-3-PYRROLIDYL)-.ALPHA.,.ALPHA.-DIPHENYL-N,N-DIMETHYLACETAMIDE